Patents by Inventor Peter Joseph Crisalli
Peter Joseph Crisalli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230183779Abstract: Embodiments provide detection systems and methods for detecting the presence of a nucleic acid in one or more samples. In a detection method, a sample and one or more nucleic acid probes are introduced into a channel. A first potential difference is applied across the length of the channel in a first direction, and a first electrical property value is detected. Subsequently, a second potential difference is applied across the length of the channel in a second opposite direction, and a second electrical property value is detected. Presence or absence of a nucleic acid in the channel is determined based on a comparison between the first and second electrical property values.Type: ApplicationFiled: October 17, 2022Publication date: June 15, 2023Inventors: Sumita Pennathur, Peter Joseph Crisalli, Ronald Phillip Chiarello
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Patent number: 11473128Abstract: Embodiments provide detection systems and methods for detecting the presence of a nucleic acid in one or more samples. In a detection method, a sample and one or more nucleic acid probes are introduced into a channel. A first potential difference is applied across the length of the channel in a first direction, and a first electrical property value is detected. Subsequently, a second potential difference is applied across the length of the channel in a second opposite direction, and a second electrical property value is detected. Presence or absence of a nucleic acid in the channel is determined based on a comparison between the first and second electrical property values.Type: GrantFiled: March 11, 2020Date of Patent: October 18, 2022Assignees: ALVEO Technologies, Inc., The Regents of the University of CaliforniaInventors: Sumita Pennathur, Peter Joseph Crisalli, Ronald Phillip Chiarello
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Publication number: 20200277660Abstract: Embodiments provide detection systems and methods for detecting the presence of a nucleic acid in one or more samples. In a detection method, a sample and one or more nucleic acid probes are introduced into a channel. A first potential difference is applied across the length of the channel in a first direction, and a first electrical property value is detected. Subsequently, a second potential difference is applied across the length of the channel in a second opposite direction, and a second electrical property value is detected. Presence or absence of a nucleic acid in the channel is determined based on a comparison between the first and second electrical property values.Type: ApplicationFiled: March 11, 2020Publication date: September 3, 2020Inventors: Sumita Pennathur, Peter Joseph Crisalli, Ronald Phillip Chiarello
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Patent number: 10627358Abstract: Embodiments provide analyte detection methods, techniques and processes for detecting the presence of one or more analytes in one or more samples. In a detection method, a sample and a sensor compound is introduced into a channel. A first potential difference is applied across the length of the channel in a first direction, and a first electrical property value is detected. Subsequently, a second potential difference is applied across the length of the channel in a second opposite direction, and a second electrical property value is detected. Presence or absence of an analyte in the channel is determined based on a comparison between the first and second electrical property values.Type: GrantFiled: October 6, 2014Date of Patent: April 21, 2020Assignees: Alveo Technologies, Inc., The Regents of the University of CaliforniaInventors: Sumita Pennathur, Peter Joseph Crisalli, Ronald Phillip Chiarello
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Patent number: 10626448Abstract: Embodiments provide detection systems and methods for detecting the presence of a nucleic acid in one or more samples. In a detection method, a sample and one or more nucleic acid probes are introduced into a channel. A first potential difference is applied across the length of the channel in a first direction, and a first electrical property value is detected. Subsequently, a second potential difference is applied across the length of the channel in a second opposite direction, and a second electrical property value is detected. Presence or absence of a nucleic acid in the channel is determined based on a comparison between the first and second electrical property values.Type: GrantFiled: December 18, 2018Date of Patent: April 21, 2020Assignees: Alveo Technologies, Inc., The Regents of the University of CaliforniaInventors: Sumita Pennathur, Peter Joseph Crisalli, Ronald Phillip Chiarello
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Patent number: 10352899Abstract: Embodiments provide silver detection systems and methods for detecting the presence of silver ions in one or more samples. In a detection method, a sample and TPEA2 molecules are introduced into a channel. A first potential difference is applied across the length of the channel in a first direction, and a first electrical property value is detected. Subsequently, a second potential difference is applied across the length of the channel in a second opposite direction, and a second electrical property value is detected. Presence or absence of silver ions in the channel is determined based on a comparison between the first and second electrical property values.Type: GrantFiled: October 6, 2014Date of Patent: July 16, 2019Assignees: ALVEO Technologies Inc., The Regents of the University of CaliforniaInventors: Sumita Pennathur, Peter Joseph Crisalli, Ronald Phillip Chiarello
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Publication number: 20190144926Abstract: Embodiments provide detection systems and methods for detecting the presence of a nucleic acid in one or more samples. In a detection method, a sample and one or more nucleic acid probes are introduced into a channel. A first potential difference is applied across the length of the channel in a first direction, and a first electrical property value is detected. Subsequently, a second potential difference is applied across the length of the channel in a second opposite direction, and a second electrical property value is detected. Presence or absence of a nucleic acid in the channel is determined based on a comparison between the first and second electrical property values.Type: ApplicationFiled: December 18, 2018Publication date: May 16, 2019Inventors: Sumita Pennathur, Peter Joseph Crisalli, Ronald Phillip Chiarello
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Patent number: 10196678Abstract: Embodiments provide detection systems and methods for detecting the presence of a nucleic acid in one or more samples. In a detection method, a sample and one or more nucleic acid probes are introduced into a channel. A first potential difference is applied across the length of the channel in a first direction, and a first electrical property value is detected. Subsequently, a second potential difference is applied across the length of the channel in a second opposite direction, and a second electrical property value is detected. Presence or absence of a nucleic acid in the channel is determined based on a comparison between the first and second electrical property values.Type: GrantFiled: November 7, 2014Date of Patent: February 5, 2019Assignees: ALVEO Technologies Inc., The Regents of the University of CaliforniaInventors: Sumita Pennathur, Peter Joseph Crisalli, Ronald Phillip Chiarello
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Patent number: 9921182Abstract: Embodiments provide mercury detection systems and methods for detecting the presence of mercury ions in one or more samples. In a detection method, a sample and TPET2 molecules are introduced into a channel. A first potential difference is applied across the length of the channel in a first direction, and a first electrical property value is detected. Subsequently, a second potential difference is applied across the length of the channel in a second opposite direction, and a second electrical property value is detected. Presence or absence of mercury ions in the channel is determined based on a comparison between the first and second electrical property values.Type: GrantFiled: October 6, 2014Date of Patent: March 20, 2018Assignees: Alveo Technologies Inc., The Regents of the University of CaliforniaInventors: Sumita Pennathur, Peter Joseph Crisalli, Ronald Phillip Chiarello
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Patent number: 9506908Abstract: Embodiments provide analyte detection systems for detecting the presence of one or more analytes in one or more samples. An exemplary detection system includes at least one channel for accommodating a sample and a sensor compound, the channel having a width and a length that is significantly greater in dimension than the width. An exemplary detection system includes an analyte detection circuit programmed or configured to detect one or more electrical properties along at least a portion of the length of the channel to determine whether the channel contains an analyte of interest.Type: GrantFiled: October 6, 2014Date of Patent: November 29, 2016Assignees: ALVEO TECHNOLOGIES, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Sumita Pennathur, Peter Joseph Crisalli, Ronald Phillip Chiarello
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Patent number: 9428791Abstract: Methods for obtaining structural data from RNA in a sample, and RNA probes for performing the same, are provided. Methods of reversibly modifying RNA is a sample, in vitro or in vivo, and reversible probes for performing the same, are provided. The RNA probes may be SHAPE probes that include aryl or heteroaryl acyl imidazoles. The RNA probes may be reversible probes that include an aryl or heteroaryl ring substituted with a hydroxyl-reactive group and an azido-containing group. Also provided are methods of comparing in vitro and in vivo RNA structural data. Also provided are methods of diagnosing a cellular proliferative disease condition, e.g., by probing HOTAIR RNA. Aspects of the invention further include compositions, e.g., probes and kits, etc., that find use in methods of the invention.Type: GrantFiled: August 14, 2013Date of Patent: August 30, 2016Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Robert Carl Spitale, Peter Joseph Crisalli, Howard Yuan-Hao Chang, Eric Todd Kool, Jong Hwa Jung
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Publication number: 20160130639Abstract: Embodiments provide detection systems and methods for detecting the presence of a nucleic acid in one or more samples. In a detection method, a sample and one or more nucleic acid probes are introduced into a channel. A first potential difference is applied across the length of the channel in a first direction, and a first electrical property value is detected. Subsequently, a second potential difference is applied across the length of the channel in a second opposite direction, and a second electrical property value is detected. Presence or absence of a nucleic acid in the channel is determined based on a comparison between the first and second electrical property values.Type: ApplicationFiled: November 7, 2014Publication date: May 12, 2016Inventors: Sumita Pennathur, Peter Joseph Crisalli, Ronald Phillip Chiarello
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Publication number: 20160097740Abstract: Embodiments provide mercury detection systems and methods for detecting the presence of mercury ions in one or more samples. In a detection method, a sample and TPET2 molecules are introduced into a channel. A first potential difference is applied across the length of the channel in a first direction, and a first electrical property value is detected. Subsequently, a second potential difference is applied across the length of the channel in a second opposite direction, and a second electrical property value is detected. Presence or absence of mercury ions in the channel is determined based on a comparison between the first and second electrical property values.Type: ApplicationFiled: October 6, 2014Publication date: April 7, 2016Inventors: Sumita Pennathur, Peter Joseph Crisalli, Ronald Phillip Chiarello
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Publication number: 20160097742Abstract: Embodiments provide analyte detection methods, techniques and processes for detecting the presence of one or more analytes in one or more samples. In a detection method, a sample and a sensor compound is introduced into a channel. A first potential difference is applied across the length of the channel in a first direction, and a first electrical property value is detected. Subsequently, a second potential difference is applied across the length of the channel in a second opposite direction, and a second electrical property value is detected. Presence or absence of an analyte in the channel is determined based on a comparison between the first and second electrical property values.Type: ApplicationFiled: October 6, 2014Publication date: April 7, 2016Inventors: Sumita Pennathur, Peter Joseph Crisalli, Ronald Phillip Chiarello
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Publication number: 20160097739Abstract: Embodiments provide analyte detection systems for detecting the presence of one or more analytes in one or more samples. An exemplary detection system includes at least one channel for accommodating a sample and a sensor compound, the channel having a width and a length that is significantly greater in dimension than the width. An exemplary detection system includes an analyte detection circuit programmed or configured to detect one or more electrical properties along at least a portion of the length of the channel to determine whether the channel contains an analyte of interest.Type: ApplicationFiled: October 6, 2014Publication date: April 7, 2016Inventors: Sumita Pennathur, Peter Joseph Crisalli, Ronald Phillip Chiarello
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Publication number: 20160097741Abstract: Embodiments provide silver detection systems and methods for detecting the presence of silver ions in one or more samples. In a detection method, a sample and TPEA2 molecules are introduced into a channel. A first potential difference is applied across the length of the channel in a first direction, and a first electrical property value is detected. Subsequently, a second potential difference is applied across the length of the channel in a second opposite direction, and a second electrical property value is detected. Presence or absence of silver ions in the channel is determined based on a comparison between the first and second electrical property values.Type: ApplicationFiled: October 6, 2014Publication date: April 7, 2016Inventors: Sumita Pennathur, Peter Joseph Crisalli, Ronald Phillip Chiarello
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Publication number: 20140154673Abstract: Methods for obtaining structural data from RNA in a sample, and RNA probes for performing the same, are provided. Methods of reversibly modifying RNA is a sample, in vitro or in vivo, and reversible probes for performing the same, are provided. The RNA probes may be SHAPE probes that include aryl or heteroaryl acyl imidazoles. The RNA probes may be reversible probes that include an aryl or heteroaryl ring substituted with a hydroxyl-reactive group and an azido-containing group. Also provided are methods of comparing in vitro and in vivo RNA structural data. Also provided are methods of diagnosing a cellular proliferative disease condition, e.g., by probing HOTAIR RNA. Aspects of the invention further include compositions, e.g., probes and kits, etc., that find use in methods of the invention.Type: ApplicationFiled: August 14, 2013Publication date: June 5, 2014Inventors: Robert Carl Spitale, Peter Joseph Crisalli, Howard Yuan-Hao Chang, Eric Todd Kool, Jong Hwa Jung