Patents by Inventor Peter K. Jackson

Peter K. Jackson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulation of cell division by an early mitotic inhibitor protein
    Patent number: 7189569
    Abstract: Emi1 regulates progression through early mitosis by preventing premature APC activation. Depleting Emi1 from cycling cells strongly delays cyclin B accumulation and mitotic entry, while expression of a stabilized form of Emi1 stabilizes APC substrates and causes a mitotic block. Emi1 binds the APC activators Cdc2O and Cdh1 and inhibits APC activation by Cdc20 or Cdh1. Hence, products that modulate the expression and/or activity of Emi1 have a therapeutic effect in the treatment of cancer, leukemia, solid tumors, chronic or acute inflammatory disease, restenosis, diabetes, neurological disorders, arthritis and osteoporosis, among other indications.
    Type: Grant
    Filed: May 24, 2002
    Date of Patent: March 13, 2007
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Peter K. Jackson, Julie Regan Reimann
  • Modulation of cell division by an early mitotic inhibitor protein
    Publication number: 20030022837
    Abstract: Emi1 regulates progression through early mitosis by preventing premature APC activation. Depleting Emi1 from cycling cells strongly delays cyclin B accumulation and mitotic entry, while expression of a stabilized form of Emi1 stabilizes APC substrates and causes a mitotic block. Emi1 binds the APC activators Cdc2O and Cdh1 and inhibits APC activation by Cdc20 or Cdh1. Hence, products that modulate the expression and/or activity of Emi1 have a therapeutic effect in the treatment of cancer, leukemia, solid tumors, chronic or acute inflammatory disease, restenosis, diabetes, neurological disorders, arthritis and osteoporosis, among other indications.
    Type: Application
    Filed: May 24, 2002
    Publication date: January 30, 2003
    Inventors: Peter K. Jackson, Julie Regan Reimann