Patents by Inventor Peter K. Working

Peter K. Working has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7279179
    Abstract: A composition for administration of a therapeutically effective dose of a topoisomerase inhibitor I or topoisomerase I/II inhibitor is described. The composition includes liposomes having an outer surface and an inner surface defining an aqueous liposome compartment, and being composed of a vesicle-forming lipid and of a vesicle-forming lipid derivatized with a hydrophilic polymer to form a coating of hydrophilic polymer chains on both the inner and outer surfaces of the liposomes. Entrapped in the liposomes is the topoisomerase inhibitor at a concentration of at least about 0.10 ?mole drug per ?mole lipid.
    Type: Grant
    Filed: October 8, 2004
    Date of Patent: October 9, 2007
    Assignee: ALZA Corporation
    Inventors: James L. Slater, Gail T. Colbern, Peter K. Working
  • Patent number: 7244449
    Abstract: A composition for administration of a therapeutically effective dose of a topoisomerase inhibitor I or topoisomerase I/II inhibitor is described. The composition includes liposomes having an outer surface and an inner surface defining an aqueous liposome compartment, and being composed of a vesicle-forming lipid and of a vesicle-forming lipid derivatized with a hydrophilic polymer to form a coating of hydrophilic polymer chains on both the inner and outer surfaces of the liposomes. Entrapped in the liposomes is the topoisomerase inhibitor at a concentration of at least about 0.10 ?mole drug per ?mole lipid.
    Type: Grant
    Filed: August 29, 2002
    Date of Patent: July 17, 2007
    Assignee: Alza Corporation
    Inventors: James L. Slater, Gail T. Colbern, Peter K. Working
  • Publication number: 20030133973
    Abstract: A composition for administration of a therapeutically effective dose of a topoisomerase inhibitor I or topoisomerase I/II inhibitor is described. The composition includes liposomes having an outer surface and an inner surface defining an aqueous liposome compartment, and being composed of a vesicle-forming lipid and of a vesicle-forming lipid derivatized with a hydrophilic polymer to form a coating of hydrophilic polymer chains on both the inner and outer surfaces of the liposomes. Entrapped in the liposomes is the topoisomerase inhibitor at a concentration of at least about 0.10 &mgr;mole drug per &mgr;mole lipid.
    Type: Application
    Filed: August 29, 2002
    Publication date: July 17, 2003
    Inventors: James L. Slater, Gail T. Colbern, Peter K. Working
  • Patent number: 6465008
    Abstract: A composition for administration of a therapeutically effective dose of a topoisomerase inhibitor I or topoisomerase I/II inhibitor is described. The composition includes liposomes having an outer surface and an inner surface defining an aqueous liposome compartment, and being composed of a vesicle-forming lipid and of a vesicle-forming lipid derivatized with a hydrophilic polymer to form a coating of hydrophilic polymer chains on both the inner and outer surfaces of the liposomes. Entrapped in the liposomes is the topoisomerase inhibitor at a concentration of at least about 0.10 &mgr;mole drug per &mgr;mole lipid.
    Type: Grant
    Filed: October 19, 2001
    Date of Patent: October 15, 2002
    Assignee: Alza Corporation
    Inventors: James L. Slater, Gail T. Colbern, Peter K. Working
  • Publication number: 20020146450
    Abstract: A composition for administration of a therapeutically effective dose of a topoisomerase inhibitor I or topoisomerase I/II inhibitor is described. The composition includes liposomes having an outer surface and an inner surface defining an aqueous liposome compartment, and being composed of a vesicle-forming lipid and of a vesicle-forming lipid derivatized with a hydrophilic polymer to form a coating of hydrophilic polymer chains on both the inner and outer surfaces of the liposomes. Entrapped in the liposomes is the topoisomerase inhibitor at a concentration of at least about 0.10 &mgr;mole drug per &mgr;mole lipid.
    Type: Application
    Filed: October 19, 2001
    Publication date: October 10, 2002
    Applicant: Alza Corporation
    Inventors: James L. Slater, Gail T. Colbern, Peter K. Working
  • Patent number: 6355268
    Abstract: A composition for administration of a therapeutically effective dose of a topoisomerase inhibitor I or topoisomerase I/II inhibitor is described. The composition includes liposomes having an outer surface and an inner surface defining an aqueous liposome compartment, and being composed of a vesicle-forming lipid and of a vesicle-forming lipid derivatized with a hydrophilic polymer to form a coating of hydrophilic polymer chains on both the inner and outer surfaces of the liposomes. Entrapped in the liposomes is the topoisomerase inhibitor at a concentration of at least about 0.10 &mgr;mole drug per &mgr;mole lipid.
    Type: Grant
    Filed: October 15, 1999
    Date of Patent: March 12, 2002
    Assignee: Alza Corporation
    Inventors: James L. Slater, Gail T. Colbern, Peter K. Working
  • Publication number: 20020028237
    Abstract: Methods for reducing the incidence and occurrence of dermal lesions in mammals, particularly human patients, who receive chemotherapy treatment and in the course of such treatment are administered liposomal formulations of cytotoxic agents are provided. Cytotoxic agents typically include doxorubicin, cytarabine, epirubicin, daunorubicin, 5-fluorouracil (5-FU) and vinorelbine. Reduction in the incidence and occurrence of dermal lesions in a patient is achieved by administration of a cytoprotective agent.
    Type: Application
    Filed: April 20, 2001
    Publication date: March 7, 2002
    Inventors: Gail T. Colbern, Karen Steinmetz, Peter K. Working, Alberto A. Gabizon