Patents by Inventor Peter K. Yonan

Peter K. Yonan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • .alpha.-Aryl-.alpha.,.alpha.-bis[.omega.-(disubstituted amino)alkyl]-acetamides
    Patent number: 4217306
    Abstract: Novel .alpha.-aryl-.alpha.,.alpha.-bis[.omega.-(disubstituted amino)alkyl]acetamides are described herein. The compounds are useful as anti-arrhythmic agents. The compounds are prepared by reacting an appropriate disubstituted acetonitrile with an appropriate haloalkyl amine and subsequently hydrolyzing the resulting nitrile with concentrated sulfuric acid.
    Type: Grant
    Filed: September 8, 1978
    Date of Patent: August 12, 1980
    Assignee: G. D. Searle & Co.
    Inventor: Peter K. Yonan
  • 5-Aryl-1-(2-oxazolin-2-yl)-1H-1,4-benzodiazepines and related compounds
    Patent number: 4208327
    Abstract: 5-Aryl-1-(2-oxazolin-2-yl)-1H-1,4-benzodiazepines and related compounds having the formula ##STR1## wherein A is methylene or carbonyl; Z is oxygen, imino or thio; R.sup.1, R.sup.2, and R.sup.3 independently are hydrogen, halogen, trifluoromethyl or nitro; R.sup.4 is hydrogen or hydroxy; and n is positive integer from 1 to 3 inclusive are disclosed. These compounds are useful because of their central nervous system activity.
    Type: Grant
    Filed: April 3, 1979
    Date of Patent: June 17, 1980
    Assignee: G. D. Searle & Co.
    Inventor: Peter K. Yonan
  • .alpha.-Aryl-.alpha., .alpha.-bis[.omega.- (disubstituted amino)alkyl]acetamides and related compounds
    Patent number: 4153797
    Abstract: Novel .alpha.-aryl-.alpha.,.alpha.-bis[.omega.-(disubstituted amino)alkyl]-acetamides are described herein. The compounds are useful as anti-arrhythmic agents. The compounds are prepared by reacting an appropriate disubstituted acetonitrile with an appropriate haloalkyl amine and subsequently hydrolyzing the resulting nitrile with concentrated sulfuric acid.
    Type: Grant
    Filed: May 1, 1978
    Date of Patent: May 8, 1979
    Assignee: G. D. Searle & Co.
    Inventors: Jerry J. Renbarger, Peter K. Yonan
  • 2-Aryl-2-[.omega.-(diis opropylamino)alkyl]-.omega.-(azabicycloalkyl)alkanamides
    Patent number: 4134890
    Abstract: Novel 2-aryl-2-[.omega.-(diisopropylamino)alkyl]-.omega.-(azabicycloalkyl)alkana mides are described herein. The present compounds are useful as anti-arrhythmic agents. The compounds are prepared by reacting an appropriate disubstituted acetonitrile with an appropriate .omega.-(azabicycloalkyl)alkyl halide and subsequent hydrolysis of the resulting nitrile with concentrated sulfuric acid.
    Type: Grant
    Filed: March 11, 1977
    Date of Patent: January 16, 1979
    Assignee: G. D. Searle & Co.
    Inventor: Peter K. Yonan
  • .alpha.-Aryl-.alpha.,.alpha.-bis[.omega.-(disubstituted amino)alkyl]acetamides and related compounds
    Patent number: 4107205
    Abstract: Novel .alpha.-aryl-.alpha.,.alpha.-bis[.omega.-(disubstituted amino)alkyl]acetamides are described herein. The compounds are useful as anti-arrhythmic agents. The compounds are prepared by reacting an appropriate disubstituted acetonitrile with an appropriate haloalkyl amine and subsequently hydrolyzing the resulting nitrile with concentrated sulfuric acid.
    Type: Grant
    Filed: March 11, 1977
    Date of Patent: August 15, 1978
    Assignee: G. D. Searle & Co.
    Inventors: Jerry J. Renbarger, Peter K. Yonan
  • N-(2-hexamethyleniminoethyl)-5H-dibenz[b,f]-azepine-5-carboxamides and quaternary ammonium derivatives thereof
    Patent number: 4076707
    Abstract: N-(hexamethyleniminoalkyl)-5H-dibenz[b,f]-azepine-5-carboxamides having anti-arrhythmic activity are described herein. The subject compounds can be prepared by reacting a 5H-dibenz[b,f]azepine-5-carbonyl chloride with the appropriate hexamethyleniminoalkylamine.
    Type: Grant
    Filed: May 24, 1976
    Date of Patent: February 28, 1978
    Assignee: G. D. Searle & Co.
    Inventor: Peter K. Yonan
  • 1-(1-Naphthoxy)-3-(4-substituted-piperidino)-2-propanols
    Patent number: 4069221
    Abstract: 1-(1-naphthoxy)-3-(4-substituted-piperidino)-2-propanols, preparable by reacting 1,2-epoxy-3-(1-naphthoxy)-propane with the appropriate 4-substituted piperidine, are disclosed. The compounds may be alternately prepared from 1-chloro-3-(1-naphthoxy)-2-propanol with the appropriate 4-substituted piperidine. The compounds are useful antiarrhythmic agents.
    Type: Grant
    Filed: November 26, 1976
    Date of Patent: January 17, 1978
    Assignee: G. D. Searle & Co.
    Inventor: Peter K. Yonan
  • 1-Aryl-3,4-dihydro-2(1H)-isoquinoline carbonyl chlorides
    Patent number: 4001244
    Abstract: 1-Aryl-3,4-dihydro-2(1H)-isoquinolinecarbonyl chlorides, useful in the preparation of the corresponding carboxamides, are described herein. The subject compounds can be prepared by reacting an 1-aryl-3,4-dihydro-2(1H)-isoquinoline with phosgene.
    Type: Grant
    Filed: April 25, 1975
    Date of Patent: January 4, 1977
    Assignee: G. D. Searle & Co.
    Inventor: Peter K. Yonan