Abstract: A medical action device is adapted to cooperate with an object to be inserted into a body and to cooperate with a timing device, able to start timing from the moment the object is inserted. This information is fed to a control unit whereby the control unit gets an input which can be used to compensate one or more parameters of the medical action as a function of the increased blood flow in the area around the inserted object over time due to the inflammation reaction.

Abstract: The invention relates to an immunogenic complex comprising at a least one glycoside and at least one lipid, integrated into an iscom complex or matrix, and at least one antigen which antigen is integrated into the iscom complex or coupled on to or mixed with the iscom complex or iscom matrix complex, characterised in that it also comprises at least one enzyme. It also relates to such a complex further comprising at least one peptide which specifically binds to a receptor expressed on a cell capable of antigen presentation, which cell expresses MHC Class I or Class II and to compositions comprising the complexes.

Abstract: The present invention pertains to the minimisation of calibration problems of glucose sensors. Accordingly, the invention provides a method of improving the performance of a ROS producing glucose sensor, said method comprising providing the glucose sensor with a ROS removing compartment capable of reducing the diffusion of ROS out of the glucose sensor to a level at which biointerference is abolished or substantially reduced. The invention further relates to use of a ROS removing compartment in a ROS producing glucose, a ROS producing glucose sensor comprising a ROS removing compartment, and to the use of such a sensor in a human.

Abstract: The invention relates to an immunogenic complex comprising at a least one glycoside and at least one lipid, integrated into an iscom complex or matrix, and at least one antigen which antigen is integrated into the iscom complex or coupled on to or mixed with the iscom complex or iscom matrix complex, characterised in that it also comprises at least one enzyme. It also relates to such a complex further comprising at least one peptide which specifically binds to a receptor expressed on a cell capable of antigen presentation, which cell expresses MHC Class I or Class II and to compositions comprising the complexes.

Abstract: There is provided an immunogenic composition comprising at least one fragment of TGF-&bgr;; capable of eliciting an immunostimulating effect in an individual, and at least one immunogenic determinant against which it is desirable to elicit an immunogenic response, wherein said at least one fragment of TGF-&bgr;; and said at least one immunogenic determinant are not identical. Following immunisation, the effect exerted by the TGF-&bgr;; fragment according to the invention results in the generation of an increased immunological response against the immunogenic determinant. By loading otherwise low immunogenic determinants into the vaccine chip according to the invention, thus generating an immunogenic composition according to the present invention, the immunogenic determinants will acquire an increased immunogenicity. There is also provided a vaccine formulation and a method for immunising an individual with the immunological compositions according to the invention.

Abstract: There is provided an immunogenic composition comprising at least one fragment of TGF-&bgr; capable of eliciting an immunostimulating effect in an individual, and at least one immunogenic determinant against which it is desirable to elicit an immunogenic response, wherein said at least one fragment of TGF-&bgr; and said at least one immunogenic determinant are not identical. Following immunisation, the effect exerted by the TGF-&bgr; fragment according to the invention results in the generation of an increased immunological response against the immunogenic determinant. By loading otherwise low immunogenic determinants into the vaccine chip according to the invention, thus generating an immunogenic composition according to the present invention, the immunogenic determinants will acquire an increased immunogenicity. There is also provided a vaccine formulation and a method for immunising an individual with the immunological compositions according to the invention.