Abstract: A method of enhancing p53 activity of a p53 mutant polypeptide is provided. The method includes interacting a compound to an open L1/S3 binding site of the p53 mutant polypeptide, where the p53 activity of the p53 mutant polypeptide is enhanced in the presence of the compound. Compounds were identified from databases of compounds for virtual drug screening. Methods of screening for compounds that enhance p53 activity by binding to the open L1/S3 binding site, and methods of treatment using the identified compounds, are also provided.

Abstract: A method of enhancing p53 activity of a p53 mutant polypeptide is provided. The method includes interacting a compound to an open L1/S3 binding site of the p53 mutant polypeptide, where the p53 activity of the p53 mutant polypeptide is enhanced in the presence of the compound. Compounds were identified from databases of compounds for virtual drug screening. Methods of screening for compounds that enhance p53 activity by binding to the open L1/S3 binding site, and methods of treatment using the identified compounds, are also provided.

Abstract: Embodiments of the present provide methods of inducing p53 SRMMP-dependent cancer cell cytotoxicity. Such methods involve the steps of exposing a cancer cell that comprises a p53 SRMMP to an amount of a chemical compound sufficient to induce p53 SRMMP-dependent cancer cell cytotoxicity. In one embodiment, the present invention provides a method of treating cancer by determining the presence of a p53 mutation, and administering a therapeutically effective dosage of a composition comprising one or more promoting compounds.

Abstract: The present invention provides a method of identifying an animal having a genotype associated with resistance to bacterial infection comprising the steps of: (a) providing a sample from said animal; (b) determining the alleles at one or more markers of the SAL1 locus to identify the genotype of the marker, wherein said SAL1 locus lies between 54.0 MB to 54.8 MB of chicken Chromosome 5 or an equivalent thereof; and (c) determining whether the genotype is a genotype associated with resistance to bacterial infection.

Abstract: A system can provide for management of a waiting list of customers at a business location for services from a no-appointment, first listed-first served business. A waiting list can be displayed on a user interface that communicates with a processor. The processor can receive customer information from an internet-based customer check-in system through which customer's check-in to the waiting list at a location remote from the business location. The user interface can display the waiting list including information regarding both customers that check-in through the internet-based check-in system and customers that check in manually at the business location giving priority temporal waiting list priority based on a time of check-in for each customer, and can display a dynamically updated calculated estimated wait time for each customer on the waiting list.

Abstract: A web-based system and method allows customers to remotely check-in to a wait list for a service from a business. A website is provided through which an address submitted by the customer can be received. Multiple locations of the business in the vicinity of the address and wait times for the service at each location can then be geographically displayed. A selection of a location at which to receive the service can be received and the customer can then be placed on a waiting list for the selected location. The multiple locations can be displayed on a map showing the relative proximity of the address and the locations. The wait times can be calculated using historical data related to the performance of the service at each location, such as the amount of time that employees at the location have taken to perform the service in the past.

Abstract: An internet-based system and method allows customers to remotely check-in to a wait list for a no-appointment first listed-first served business. A location associated with a customer is received and an interactive map displays multiple icons with each icon corresponding to a location of the business. A dynamically updated estimated wait time for the wait list at each business location is displayed. A customer selection of a location at which to receive a service from the business is received by a selection of the icon representing the business and the customer is added to the wait list at the location.

Abstract: The present invention provides a method of identifying an animal having a genotype associated with resistance to bacterial infection comprising the steps of: (a) providing a sample from said mammal; (b) determining the alleles at one or more markers of the SAL1 locus to identify the genotype of the marker, wherein said SAL1 locus lies between 54.0 MB to 54.8 MB of chicken Chromosome 5 or an equivalent thereof; and (c) determining whether the genotype is a genotype associated with resistance to bacterial infection.

Abstract: A web-based system and method allows customers to remotely check-in to a wait list for a service from a business. A website associated with the business is provided through which an address submitted by the customer can be received. Multiple locations of the business in the vicinity of the address and wait times for the service at each location can then be geographically displayed. A selection by the customer of a location at which to receive the service can be received and the customer can then be placed on a waiting list for the selected location. The multiple locations can be displayed on a map showing the relative proximity of the address and the locations and driving directions from the address to the selected location can be provided. The wait times can be calculated using historical data related to the performance of the service at each location, such as the amount of time that employees at the location have taken to perform the service in the past.

Abstract: The invention relates to a device and method for carrying out a contactless measurement of the conductivity of a liquid situated in a flow channel, and to the use of said device and method. According to the invention, the invention provides that a toroidal coil is precisely arranged around the flow channel. Said toroidal coil is interconnected with a capacitor to an oscillating circuit. The invention also provides that the electric characteristics of this circuit are then measured according to the conductivity which is sought after.

Abstract: A sun visor for automotive vehicles, including a sun visor body and a separate carrier body. The carrier body and sun visor body being attached to permit longitudinal translation of the visor body with respect to the carrier body while prohibiting rotation of the carrier body apart from the visor body around a swivel axis. Slide bearing rails between the carrier body and visor body permit the longitudinal translation. The arms of the U shape slide rails are cooperatingly shaped to define ball-receiving grooves which enable the translation of the visor body with respect to the carrier body. A sun visor swivel shaft is supported at one end of the carrier body. An outer support pin, supported at the opposite end of the carrier body, is also longitudinally movable with respect to the carrier body and is also received in a hole in the end of the outer support pedestal, which hole has a lateral radial opening.

Abstract: The electrode has a durable upper part and a consumable tip. A plurality of copper tubes extend through the upper part. The connection to the consumable tip is by means of an intermediate plate and a nipple, the latter containing ducts for the connection of the copper tubes. At the upper end of the electrode, the copper tubes are serially interconnected by tube bends and at their lower end by ducts in the nipple.

Abstract: The disclosure concerns a sun visor for a vehicle and concerns various ways in which a piece of covering material is clamped in place over the exterior of the sun visor body. In all embodiments, the border of the piece of material is clamped in a groove in the sun visor body. The groove may be around the periphery. Alternatively, the visor body is comprised of two facing plates and the material is clamped between the plates. Pins on one plate may hold the material in place. Various clamping devices for clamping the border of the material between the plates are disclosed, including simply clamping the two plates together with the material between them, a mortise and tenon joint at the borders of the plates, a reinforcing strip between the plates which clamps the border of the material and the material having a drawstring around its hem for pulling the border tightly into the visor body.

Abstract: The disclosure concerns an outer support bracket for use in the body of a vehicle for supporting the outer support shaft of a sun visor. The sun visor is supported by a swivel bearing at one end and by an outer support shaft at the other end. The bracket for the latter includes a base part secured to the vehicle body and a head part swingably mounted to the base part. A support opening extending across the head part receives the outer support shaft of the sun visor body and the head part is movable for reorienting the support opening to the orientation of the outer support shaft. A radially positioned introduction slot permits introduction of the support shaft into the support opening. The head part is swingable on the base part around a semi-cylindrically curved set of cooperating surfaces on the head part and base part and the head part projects from within the base part to the exterior of the base part through an opening in the base part.

Abstract: The invention concerns the swivel bearing of a sun visor for an automotive vehicle. The swivel bearing connects the body of the sun visor with a mounting shaft for the sun visor. A protective housing comprised of injection molded plastic surrounds the swivel bearing housing. The protective housing is a single piece comprised of two halves which are hinged together along one edge and are clipped together at their opposite edge to surround the swivel bearing housing. The exterior of the protective housing is profiled so that all edges, corners and any other deformed part thereof has an outer contour radius of at least 3.2 mm. for eliminating sharp edges at the swivel bearing. The protective housing has an interior contour adapted to the outer contour of the swivel bearing housing.

Abstract: A method for drawing silica fibers utilizing an electrical resistance furnace includes the steps of heating a preform so that it begins to flow forming a fiber; pulling the fiber from the furnace; and flushing the preform and the fiber within the furnace with counteracting inert gas flows, the gas flows protecting the preform and the fiber from contamination.Apparatus used with the above-described method is also disclosed.

Abstract: The disclosure is directed to optical fiber waveguiding structures, and techniques for fabricating the same, which are designed to have reduced modal dispersion as a result of the deliberate enhancement of mode coupling in the fibers. The mode coupling is achieved in each of the structures by means of an enveloping outer jacket, typically of plastic, which is selectively deformed so as to modify the straightness of the fiber axes in a spatially periodic manner. Several alternative techniques are presented for properly deforming the outer jacket either before or after it is combined with the fibers. Since, with these structures and techniques, the outer jacket provides the desired fiber perturbations, the fibers themselves can be fabricated using standard techniques without the need for any special procedures for modifying their parameters.