Patents by Inventor Peter Kambouris
Peter Kambouris has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 8273403Abstract: This invention relates to a surface discovery system and high-throughput combinatorial synthesis methods for generating large numbers of diverse surface coatings on solid substrates. The system is built upon a synthon which comprises at least three elements: a chemical backbone coating on the solid substrate that comprises a copolymer (B) of at least one passive constituent (P) and at least one active constituent (A); a spacer unit (S) separating the backbone from a functional group; and a functional group (F). The methods comprise the following steps: 1) selecting a plurality of synthons so that each synthon has at least two points of diversity selected from P, A, S and F; 2) applying copolymer B onto a substrate; and 3) attaching a combination of S and F to constituent A of copolymer B. Steps 2) and 3) are performed such that different synthons are generated on localized regions of the substrate.Type: GrantFiled: May 9, 2003Date of Patent: September 25, 2012Assignee: Bio-Layer Pty Ltd.Inventors: Michael C. Barden, Peter A. Kambouris
-
Publication number: 20060083858Abstract: The present invention relates to a surface discovery system comprising chemical compositions and high-throughput combinatorial synthesis methods for generating large numbers of diverse surface coatings on solid substrates. This surface discovery platform is built upon a fundamental chemical unit refereed to as a synthon. Each synthon comprises at least three elements: a chemical backbone coating on the solid substrate that comprises a passive (P) constituent and an active (A) constituent; a spacer unit (S) separating the backbone from a functional group; and a functional group (F). Variation of these synthon elements allows generation of large libraries surface coatings with a broad range of molecular and macroscopic properties. Further the spectrum of surfaces provided by the invention permits optimization of the wide range of solid-phase applications that involve surface immobilization of molecules.Type: ApplicationFiled: May 9, 2003Publication date: April 20, 2006Inventors: Michael Barden, Peter Kambouris
-
Patent number: 6893685Abstract: The invention relates to a process for coating a material surface, comprising the steps of: (a) applying to the material surface a tie layer comprising a polyionic material; (b) covalently binding a bifunctional compound comprising an ethylenically unsaturated double b3nd to the tie layer; and (c) graft polymerizing a hydrophilic monomer onto the compound comprising the ethylenically unsaturated double bond. The coated articles that are obtainable by the process of the invention have desirable characteristics regarding adherences to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus useful for the manufacture of biomedical articles such as ophthalmic devices.Type: GrantFiled: August 24, 2001Date of Patent: May 17, 2005Assignee: Novartis AGInventors: Yongxing Qiu, Lynn Cook Winterton, John Martin Lally, Paul Pasic, Hans Griesser, Peter Kambouris, Peter Chabrecek
-
Patent number: 6858309Abstract: The present invention provides improved methods for conducting living/controlled polymerization on polymeric solid supports. The improved methods allow polymerization to occur directly from the non-functionalized surface of a bulk support. In addition, polymerization may be re-initiated to provide co-polymers. The disclosed methods may employ the non-nitroxide-based RAFT and ATRP control agents that allow controlled polymerization to proceed at relatively low temperatures (<80° C.). Furthermore, these improved methods may provide graft polymers with decreased levels of “in-growth” of the bulk solid support. The invention also provides substrate polymers, with improved properties for solid phase synthesis and diagnostic applications, which may be made by the disclosed methods.Type: GrantFiled: March 28, 2002Date of Patent: February 22, 2005Assignee: Polymerat Pty. Ltd.Inventors: Peter Kambouris, Michael Whittaker, Tom Davis, Idriss Blakey, Gary M. Day
-
Publication number: 20050004255Abstract: A hydrophilic ethylenically unsaturated macromonomer is disclosed that is prepared by the addition polymerization of addition polymerizable monomers that include monomers that have hydroxyl or amino functional groups, some of which may be subsequently reacted to provide (meth)acryl ethylenic unsaturation. The macromonomers may be used to form intraocular lenses in situ by polymerization of the macromonomers, and thus treat presbyopia.Type: ApplicationFiled: July 22, 2004Publication date: January 6, 2005Applicant: Commonwealth Scientific and Industrial Research OrganisationInventors: Anthony Clayton, Timothy Hughes, Peter Kambouris, Gordon Meijs
-
Publication number: 20040236027Abstract: The present invention relates generally to a polymer having co-continuous architecture. More particularly, the present invention is directed to a single or plurality of polymer layers in polymeric, co-polymeric, hybrid or blend formation comprising at least one polymer layer having co-continuous architecture. The co-continuous architecture of the one or more polymers permits or otherwise facilitates accessibility of functional groups to an external environment or at least one polymeric layer. The accessible, i.e. co-continuous, nature of the functional groups, in or on the one or more polymers facilitates solid phase chemical processes, chromatography and ion exchange applications. The one or more polymers may also be used as a solid support for a range of diagnostic applications.Type: ApplicationFiled: October 28, 2003Publication date: November 25, 2004Inventors: Nobuyoshi Joe Maeji, Firas Rasoul, Peter Kambouris, Liying Shao, Michael Whittaker
-
Patent number: 6582754Abstract: The invention relates to a process for coating a material surface, comprising the steps of: (a) covalently binding a compound comprising an ethylenically unsaturated double bond to the material surface; (b) polymerizing a monomer comprising a reactive or crosslinkable group on the surface and thereby providing a primary polymer coating comprising reactive or crosslinkable groups, (c) in case of a monomer comprising a reactive group in step (b) reacting the reactive groups of the primary coating with a further compound comprising an ethylenically unsaturated double bond and graft-polymerizing a hydrophilic monomer and optionally a co-monomer having a crosslinkable group onto the primary coating obtained according to step (b) and (d) in case of crosslinkable groups being present in step (b) or (c) initiating crosslinking of said groups.Type: GrantFiled: October 27, 2000Date of Patent: June 24, 2003Assignee: Novartis AGInventors: Paul Pasic, Hans Jörg Griesser, Peter Kambouris, Peter Chabrecek
-
Publication number: 20030088028Abstract: The present invention provides improved methods for conducting living/controlled polymerization on polymeric solid supports. The improved methods allow polymerization to occur directly from the non-functionalized surface of a bulk support. In addition, polymerization may be re-initiated to provide co-polymers. The disclosed methods may employ the non-nitroxide-based RAFT and ATRP control agents that allow controlled polymerization to proceed at relatively low temperatures (<80° C.). Furthermore, these improved methods may provide graft polymers with decreased levels of “in-growth” of the bulk solid support. The invention also provides substrate polymers, with improved properties for solid phase synthesis and diagnostic applications, which may be made by the disclosed methods.Type: ApplicationFiled: March 28, 2002Publication date: May 8, 2003Inventors: Peter Kambouris, Michael Whittaker, Tom Davis, Idriss Blakey, Gary M. Day
-
Publication number: 20030022994Abstract: The present invention generally relates to polymers, including substrate polymers and hybrid polymers, having co-continuous architecture. The co-continuous architecture of the polymers of the present invention facilitates accessibility of functional groups to an external environment thereby making the polymers useful for a number of applications including solid phase chemistry, chromatography, and diagnostics. The present invention provides a number of methods for generating substrate polymers and hybrid polymers having co-continuous architecture including methods of grafting and macroporous formulation.Type: ApplicationFiled: January 17, 2002Publication date: January 30, 2003Inventors: Nobuyoshi Joe Maeji, Firas Rasoul, Peter Kambouris, Liying Shao, Michael Whittaker
-
Publication number: 20020086160Abstract: The invention relates to a process for coating a material surface, comprising the steps of:Type: ApplicationFiled: August 24, 2001Publication date: July 4, 2002Inventors: Yongxing Qiu, Lynn Cook Winterton, John Martin Lally, Paul Pasic, Hans Griesser, Peter Kambouris, Peter Chabrecek