Patents by Inventor Peter Karayiannis

Peter Karayiannis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hepatitis B vaccine
    Patent number: 5856084
    Abstract: A variant or so-called "escape mutant" HBsAg protein or fragment thereof displaying the antigenicity of hepatitis B virus surface antigen is disclosed, in which the mutant protein or fragment thereof (mHBsAg) comprises a modified `a` determinant in which at least two amino acids are inserted downstream of position 122 of the wild type HBsAg sequence. A vaccine comprising the mHBsAg is provided, as is a kit for diagnostic in vitro detection of anti-mHBsAg antibodies and an antibody preparation comprising anti-mHBsAg antibodies.
    Type: Grant
    Filed: December 28, 1995
    Date of Patent: January 5, 1999
    Assignee: Imperial College of Science, Technology & Medicine
    Inventors: Peter Karayiannis, Howard Christopher Thomas
  • Expression of structural (P1) region of 1 hepatitis A virus by vaccinia in cell culture for use in vaccines
    Patent number: 5605692
    Abstract: An isolated polypeptide comprising a substantially antigenic part of at least one hepatitis A virus epitope, the polypeptide being free from infectious material. The polypeptide is the expression product of a DNA molecule which has been incorporated into a virus, preferably vaccinia virus, using recombinant DNA technology. This expression product, of the recombinant virus containing the DNA molecule coding for it, may be incorporated into a vaccine for immunising against hepatitis A virus.
    Type: Grant
    Filed: July 31, 1992
    Date of Patent: February 25, 1997
    Assignee: Imperial College of Science, Technology and Medicine
    Inventors: Howard C. Thomas, Peter Karayiannis