Abstract: A linear actuator includes an outer housing, an inner arm disposed within and extending from an open end of the outer housing, and a seal arranged radially between the outer housing and the inner arm so as to prevent passage of fluid and particle contamination between the outer housing and the inner arm. The seal includes a first seal, a second seal, and a felt ring configured to sealingly engage the inner arm.

Abstract: The disclosure relates to a planetary roller screw drive comprising a threaded spindle nut, a horizontal threaded spindle, a plurality of planetary rolling elements having a planetary rolling element profile, and at least two planetary guide rings. The threaded spindle is arranged concentrically in the planetary guide rings and the spindle nut. The planetary guide rings can be rotated relative to the threaded spindle and the planetary rolling elements are mounted so as to be rotatable about their associated planetary rolling element axis in the planetary guide rings and inside the spindle nut. The planetary rolling element profile of the planetary rolling elements meshes with the threaded spindle. The planetary guide rings are connected to a housing case for conjoint rotation, and the housing case has a housing case lateral surface on which a toothing is formed for coupling in a geared manner to with a continuous traction mechanism.

Abstract: Provided herein are salt and crystalline forms of (S)-mepazine, formulations of the same, uses of the same, and processes of preparing (S)-mepazine.

Abstract: The disclosure relates to a planetary roller screw having: a nut arranged on a threaded spindle and divided crosswise to a spindle axis into two nut parts; planetary rollers arranged between the threaded spindle and the nut distributed over the circumference, the planetary rollers intermeshing with the nut parts and with the threaded spindle; a rotatingly driven planetary roller carrier arranged on the threaded spindle, in pockets of which, arranged distributed over the circumference, the planetary rollers are mounted, held at a distance in the circumferential direction, so as to be rotatable about the planetary roller axis; and a housing in which the planetary roller carrier is rotatably mounted. A pre-loading device is provided in order to adjust an axial pre-load between the housing and the planetary rollers.

Abstract: The present disclosure provides a method of treating cancer in a subject in need thereof comprising administering a therapeutically effective amount of a MALT-1 inhibitor to the subject; optionally in combination with a checkpoint inhibitor, wherein the MALT-1 inhibitor is administered at a continuous daily dose over a treatment cycle.

Abstract: A process for producing a three-dimensional object by selectively layer-by-layer solidification of a powdery material layer at the locations corresponding to the cross-section of the object in a respective layer by exposure to electromagnetic radiation. The powdery material comprises at least one polymer which is obtainable from its melt only in substantially amorphous or completely amorphous form, or a polyblend which is obtainable from its melt only in substantially amorphous or completely amorphous form. The powdery material has a specific melting enthalpy of at least 1 J/g.

Abstract: A device for an adjustment of a heater control includes a nominal parameter provision unit designed such that it provides at least one nominal parameter value, an actual parameter detection unit designed such that it is able to detect for at least one of the nominal parameter values the corresponding actual parameter value in a heater control or in an additive manufacturing device, wherein an actual parameter value is the actual value of a controlled variable and/or the actual value of its change with time and/or the actual value of a heater parameter and/or the actual value of its change with time, and a control change unit that automatically changes at least one control parameter value, if a predefined difference between the nominal parameter value and its corresponding actual parameter value is exceeded.

Abstract: The present disclosure provides a method of treating cancer in a subject in need thereof comprising administering a checkpoint inhibitor to the subject, and administering a MALT-1 inhibitor according to an intermittent dosage regimen.

Abstract: The disclosure relates to a planetary roller screw having: a nut arranged on a threaded spindle and divided crosswise to a spindle axis into two nut parts; planetary rollers arranged between the threaded spindle and the nut distributed over the circumference, the planetary rollers intermeshing with the nut parts and with the threaded spindled; a rotatingly driven planetary roller carrier arranged on the threaded spindle, in pockets of which, arranged distributed over the circumference, the planetary rollers are mounted, held at a distance in the circumferential direction, so as to be rotatable about the planetary roller axis; and a housing in which the planetary roller carrier is rotatably mounted. A pre-loading device is provided in order to adjust an axial pre-load between the housing and the planetary rollers.

Abstract: A threaded fastener system including a female threaded part and a male threaded dual driven fastener. The dual driven fastener has a shaft having a longitudinal axis, a portion of the shaft having a male threaded feature that engages the female threaded part. The male threaded feature having a major thread diameter and a minor thread diameter. There is a first driving feature at a first end of the shaft that is larger than the major thread diameter relative to the longitudinal axis and a second driving feature at a second end of the shaft that is equal to or smaller than the minor thread diameter. The driving features allow torquing of the dual driven fastener from either end.

Abstract: The disclosure relates to a planetary roller screw drive comprising a threaded spindle nut, a horizontal threaded spindled, a plurality of planetary rolling elements having a planetary rolling element profile, and at least two planetary guide rings. The threaded spindle is arranged concentrically in the planetary guide rings and the spindle nut. The planetary guide rings can be rotated relative to the threaded spindle and the planetary rolling elements are mounted so as to be rotatable about their associated planetary rolling element axis in the planetary guide rings and inside the spindle nut. The planetary rolling element profile of the planetary rolling elements meshes with the threaded spindle. The planetary guide rings are connected to a housing case for conjoint rotation, and the housing case has a housing case lateral surface on which a toothing is formed for coupling in a geared manner to with a continuous traction mechanism.

Abstract: Systems and methods for starting an engine that is incorporated into a hybrid vehicle driveline are described. In one example, a torque converter clutch is fully opened if a threshold amount has transpired after a request for torque converter clutch slip is requested but not delivered. Further, the torque converter clutch may be fully opened if a commanded torque converter clutch torque capacity is less than a threshold torque capacity.

Abstract: The subject matter of the present invention relates to a method for dynamically assigning identification data for a configuration of a product configuration system, the method comprising the following method steps: acquiring (S1) a configuration data set for the configuration, the configuration data set having configuration property data; and providing (S2) a variant data set for variant configurations, the variant data set having item property data and identifier data of each item of a plurality of items; and comparing (S3) the configuration data set with the variant data set, wherein in case of a match of configuration property data of the configuration with article property data of a particular article of the variant data set, the identification data of the particular article of the variant data set is dynamically assigned to the configuration of the configuration data set; and generating (S4) an article reference number in case of no match of configuration properties of the configuration with the article

Abstract: The present invention relates to a method for converting data from a digital customer interface of a computer network system. The method includes acquiring standard functions both from participating systems of the computer network system and from the digital customer interface, determining semantic relationships between the acquired standard functions, and performing an orchestration in the form of a flexible combining of the acquired standard functions based on the determined semantic relationships to a data composition for internal material and/or value flows.

Abstract: A manufacturing method for generatively manufacturing a three-dimensional object by a layer-by-layer application and selective solidification of a building material includes applying a layer of the building material within a build area by means of a recoater moving in a recoating direction across the build area, selectively solidifying the applied layer of the building material at points corresponding to a cross-section of the object to be manufactured by means of a solidification device, and repeating the steps of applying and solidifying until the three-dimensional object is completed. A local action confined to a region between the recoating unit moving across the build area and the solidification device and/or compaction device moving behind the recoating unit across the build area is performed on the applied layer of the building material.

Abstract: A method for assisting bay parking maneuvers of a vehicle includes locating, by a sensor system of the vehicle, an unoccupied parking space in a bay parking area. The method includes acquiring, by the sensor system, parking data on the unoccupied parking space, the parking data including information on positions of vehicles parking laterally adjacent to the unoccupied parking space in the bay parking area. The method includes deciding, by a decision unit of the vehicle, based on the parking data, if the vehicle fits into the unoccupied parking space side-to-side with at least one of the other vehicles, wherein a predefined lateral clearance is taken into account on both lateral sides of the vehicle. The method includes providing, by a steering assistant unit of the vehicle, steering instructions for steering the vehicle into the unoccupied parking space adjacent to the respective parking vehicle in observance with the predefined lateral clearance.

Abstract: Method for manufacturing a three-dimensional object by layer-wise application and selective solidification of a building material with the step of applying a layer of the building material on a building base within a build area and with the step of selectively solidifying the applied layer by solidifying an area of the applied layer which corresponds to the cross-section of the object in the layer in order to produce a solidified area in the layer. The steps of applying and selectively solidifying are repeated until the three-dimensional object is completed. At least once during manufacturing the three-dimensional object, a sub-area that is only a predetermined portion of the solidified area is after-treated. The sub-area is located substantially inside the solidified area.

Abstract: A device for an adjustment of a heater control includes a nominal parameter provision unit designed such that it provides at least one nominal parameter value, an actual parameter detection unit designed such that it is able to detect for at least one of the nominal parameter values the corresponding actual parameter value in a heater control or in an additive manufacturing device, wherein an actual parameter value is the actual value of a controlled variable and/or the actual value of its change with time and/or the actual value of a heater parameter and/or the actual value of its change with time, and a control change unit that automatically changes at least one control parameter value, if a predefined difference between the nominal parameter value and its corresponding actual parameter value is exceeded.

Abstract: A device for an adjustment of a heater control in an additive manufacturing device, in which a heater control regulates the heating of an applied building material layer by means of a heating device (17) up to a work temperature (TA) comprises: a nominal parameter provision unit (201) designed such that it provides at least one nominal parameter value, meaning the setpoint of a controlled variable and/or its change with time and/or the setpoint of a heater parameter and/or its change with time, an actual parameter detection unit (202) designed such that it is able to detect for at least one of the nominal parameter values the corresponding actual parameter value in the heater control or in the additive manufacturing device, wherein an actual parameter value is the actual value of a controlled variable and/or the actual value of its change with time and/or the actual value of a heater parameter and/or the actual value of its change with time, and a control change unit (203) that automatically changes at lea

Abstract: A method is presented that makes possible the labelling of powders that can be applied as building material in a layer-additive manufacturing method such as a selective laser sintering method. To this effect the powder is mixed with at least one salt of a metal of the rare earths, wherein the salt has the property that it shows a luminescence when being irradiated with photons having a wavelength outside of the visible spectrum or with particle radiation. Thereby, parts that have been manufactured by means of the layer-additive manufacturing method can be identified with regard to the manufacturer, the place of manufacture or the manufacture date.