Abstract: A three-dimensional printer for the additive manufacturing of a part is provided. The printer includes a build platen, a pre-extrusion system, and a print head located downstream of the pre-extrusion system and configured to receive and deposit a filament. The print head includes a receiving section configured to receive the filament, an outlet through which the filament is deposited onto the build platen or a previously added layer of a part, a feeding mechanism constructed and arranged to feed the filament into the outlet, and a path length adjustment system positioned on the print head disposed between the pre-extrusion system and the feeding mechanism. The path length adjustment system constructed and arranged to create slack in the filament being delivered from the pre-extrusion system. Path length adjustment devices incorporating sliding components and flexure components are also disclosed.

Abstract: Provided herein are free base crystalline forms, crystalline salts, and an amorphous salts of omecamtiv mecarbil.

Abstract: An aircraft wing trailing edge section assembly is disclosed having an upper skin structure providing an upper external aerodynamic trailing edge surface, a lower skin structure providing a lower external aerodynamic trailing edge surface, and a movement mechanism including a first portion attached to an internal surface of the upper skin structure, a second portion attached to an internal surface of the lower skin structure, and a rotationally mounted connector member connected between the first and second portions, such that rotational movement of the connector member causes simultaneous movement of both first and second portions and therefore both upper and lower skin structures, such that the camber of the trailing edge section is changed. An aircraft wing section assembly, an aircraft and methods of operating an aircraft are disclosed.

Abstract: An aircraft wing section assembly is disclosed having a structural spine, a movement mechanism including a support rod extending through the structural spine, a first lever, for connection to and for moving a first moveable control surface, pivotally mounted to the support rod, a second similar lever for connection to and for moving a second moveable control surface, and a connection mechanism for connecting the first and second levers such that pivotal movement of the first lever causes pivotal movement of the second lever, and an actuation mechanism for actuating pivotal movement of the first lever, such that, in use, when the actuation mechanism actuates pivotal movement of the first lever, the second lever also pivotally moves, thus causing movement of both the first and second moveable control surfaces. Also disclosed is an aircraft wing assembly, an aircraft and a method of operating an aircraft.

Abstract: An aircraft wing trailing edge section assembly is disclosed having an upper skin structure providing an upper external aerodynamic trailing edge surface, a lower skin structure providing a lower external aerodynamic trailing edge surface, and a movement mechanism including a first portion attached to an internal surface of the upper skin structure, a second portion attached to an internal surface of the lower skin structure, and a rotationally mounted connector member connected between the first and second portions, such that rotational movement of the connector member causes simultaneous movement of both first and second portions and therefore both upper and lower skin structures, such that the camber of the trailing edge section is changed. An aircraft wing section assembly, an aircraft and methods of operating an aircraft are disclosed.

Abstract: An aircraft wing section assembly is disclosed having a structural spine, a movement mechanism including a support rod extending through the structural spine, a first lever, for connection to and for moving a first moveable control surface, pivotally mounted to the support rod, a second similar lever for connection to and for moving a second moveable control surface, and a connection mechanism for connecting the first and second levers such that pivotal movement of the first lever causes pivotal movement of the second lever, and an actuation mechanism for actuating pivotal movement of the first lever, such that, in use, when the actuation mechanism actuates pivotal movement of the first lever, the second lever also pivotally moves, thus causing movement of both the first and second moveable control surfaces. Also disclosed is an aircraft wing assembly, an aircraft and a method of operating an aircraft.

Abstract: This disclosure includes devices, systems, apparatuses, and implementations associated with a wall-mounted beverage dispensing system. The beverage dispensing system is configured to fit between standard space between studs. In some implementations, the studs may provide the sole support for the beverage dispensing system. The beverage dispensing system may include a filter that is accessible for replacement without the use for tools.

Abstract: A computer detects a crash of a computer program, the crash being caused by a faulting instruction. The computer determines, within concrete stack frame(s) of the computer program, memory position(s) and extent(s) of input. The computer maps, using the memory position(s) and the extent(s), inferred stack frame(s) onto concrete stack frame(s), the inferred stack frame(s) indicating positions of variables used in the computer program. The computer identifies, based on mapping the inferred stack frame(s) onto the concrete stack frame(s), at least one variable from among the variables that is within a stack overflow memory and within a dataflow path to the faulting instruction, wherein the dataflow path to the faulting instruction indicates the variables used in the computer program that are accessed by or contribute to the faulting instruction. The computer determines whether the stack overflow contributed to the crash of the computer program.

Abstract: A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism having an objective substance-producing ability, which microorganism has been modified so that the activity of S-adenosyl-L-homocysteine hydrolase is increased.

Abstract: This disclosure includes devices, systems, apparatuses, and implementations associated with a wall-mounted beverage dispensing system. The beverage dispensing system is configured to fit between standard space between studs. In some implementations, the studs may provide the sole support for the beverage dispensing system. The beverage dispensing system may include a filter that is accessible for replacement without the use for tools.

Abstract: The present invention relates to a new class of steroid saponins that have interesting biological activity. In particular the present invention relates to a class of steroid saponins in which the sugar moiety has been selectively functionalised to introduce a moiety that contains either, (i) a hydrogen ion donor, (ii) a hydrogen ion acceptor or (iii) a combination thereof. These new, water-soluble compounds are found to not only have potent anti-cancer properties per se but also have the ability to promote the immune response in a subject and can thus act as adjuvants for T-cell activation in cancer therapy.

Abstract: This disclosure includes devices, systems, apparatuses, and implementations associated with a wall-mounted beverage dispensing system. The beverage dispensing system is configured to fit between standard space between studs. In some implementations, the studs may provide the sole support for the beverage dispensing system. The beverage dispensing system may include a filter that is accessible for replacement without the use for tools.

Abstract: A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism having an objective substance-producing ability, which microorganism has been modified so as to have a specific feature, such as a reduced activity of AICAR formyltransferase/IMP cyclohydrolase, an increased activity of 3-PGDH, and/or a reduced activity of L-serine deaminase.

Abstract: This disclosure includes devices, systems, apparatuses, and implementations associated with a wall-mounted beverage dispensing system. The beverage dispensing system is configured to fit between standard space between studs. In some implementations, the studs may provide the sole support for the beverage dispensing system. The beverage dispensing system may include a filter that is accessible for replacement without the use for tools.

Abstract: The present disclosure provides a HTP microbial genomic engineering platform for Saccharopolyspora spp. that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols. This integrative platform utilizes a suite of HTP molecular tool sets to create HTP genetic design libraries, which are derived from, inter alia, scientific insight and iterative pattern recognition.

Abstract: The present disclosure is directed to a method of high-throughput (HTP) microbial genomic engineering, which utilizes in vivo transposon mutagenesis to develop strain libraries for the perturbation of microbial phenotypes.