Patents by Inventor Peter Kofinas
Peter Kofinas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240021873Abstract: The present invention is directed to aqueous solid polymer electrolytes that comprise a lithium salt and battery cells comprising the same. The present invention is also directed to methods of making the electrolytes and methods of using the electrolytes in batteries and other electrochemical technologies.Type: ApplicationFiled: April 6, 2023Publication date: January 18, 2024Applicants: High Performance Air Stable Solid Polymer Electrolyte, The United States of America as Represented by the Secretary of the ArmyInventors: Matthew D. WIDSTROM, Peter KOFINAS, Arthur V. CRESCE, Kang XU
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Publication number: 20230310695Abstract: Provided are compositions and methods that involve viscoelastic poly(lactide-co-caprolactone) (PLCL) mixtures for use in wound healing. The PLCL mixtures provide an improved anti-fibrotic yet tissue-adhesive polymer sealant. The PLCL mixtures can be applied to a variety of wounds arising from surgical and non-surgical tissue damage.Type: ApplicationFiled: March 30, 2023Publication date: October 5, 2023Inventors: Metecan ERDI, Peter KOFINAS, Omar B. AYYUB, Anthony SANDLER, Michele SARUWATARI
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Patent number: 11631892Abstract: The present invention is directed to aqueous solid polymer electrolytes that comprise a lithium salt and battery cells comprising the same. The present invention is also directed to methods of making the electrolytes and methods of using the electrolytes in batteries and other electrochemical technologies.Type: GrantFiled: January 7, 2019Date of Patent: April 18, 2023Assignees: University of Maryland, College Park, The United States of America as Represented by the Secretary of the ArmyInventors: Matthew D. Widstrom, Peter Kofinas, Arthur V. Cresce, Kang Xu
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Publication number: 20220160929Abstract: The present disclosure relates to a biocompatible composition comprising a solution of low molecular weight polymer and high molecular weight polymer. The present disclosure also relates to biocompatible compositions comprising poly(lactic-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG), and additionally including a suspension of silica particles and/or a therapeutic agent. The present disclosure is also directed to biocompatible polymer fiber constructs formed from the disclosed compositions, methods of fabrication thereof, and uses of such constructs and compositions.Type: ApplicationFiled: March 10, 2020Publication date: May 26, 2022Applicants: University of Maryland, College Park, Children's National Medical CenterInventors: John Daristotle, Shadden Zaki, Peter Kofinas, Anthony Sandler, Lung Lau, Leopoldo Torres
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Patent number: 10620187Abstract: The present disclosure relates to a biosensor capable of measuring the total concentration of one or a plurality of ammonia or ammonium ions with the use of indophenol reagents in the presence of an ionomer. In some embodiments, the biosensor comprises a perfluorinated membrane that comprises an ionomer in contact with an alkali buffer in a vessel configured to receive a sample, such as whole blood. The disclosure also relates to a method of detecting or quantifying the ammonia or ammonium ion concentration in whole blood in a point of care bio sensor without reliance on gas chromatography or any measurement that takes more than about twenty minutes.Type: GrantFiled: March 23, 2018Date of Patent: April 14, 2020Assignees: University of Maryland, College Park, Children's National Medical CenterInventors: Omar Bilal Ayyub, Adam Michael Behrens, Peter Kofinas, Marshall Lynn Summar, Juan Manuel Cabrera-Luque, Gary Cunningham, Anton Simeonov, Juan Marugan
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Patent number: 10591495Abstract: The present disclosure relates to a biosensor capable of measuring the total concentration of one or a plurality of ammonia or ammonium ions with the use of indophenol reagents in the presence of an ionomer. In some embodiments, the biosensor comprises a perflurinated membrane that comprises an ionomer in contact with an alkali buffer in a vessel configured to receive a sample, such as whole blood. The disclosure also relates to a method of detecting or quantifying the ammonia or ammonium ion concentration in whole blood in a point of care bio sensor without reliance on gas chromatography or any measurement that takes more than about twenty minutes.Type: GrantFiled: April 27, 2016Date of Patent: March 17, 2020Assignees: University of Maryland, College Park, Children's National Medical CenterInventors: Omar Bilal Ayyub, Adam Michael Behrens, Peter Kofinas, Marshall Lynn Summar, II, Juan Manuel Cabrera-Luque, Gary Cunningham
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Publication number: 20200028210Abstract: The present invention is directed to aqueous solid polymer electrolytes that comprise a lithium salt and battery cells comprising the same. The present invention is also directed to methods of making the electrolytes and methods of using the electrolytes in batteries and other electrochemical technologies.Type: ApplicationFiled: January 7, 2019Publication date: January 23, 2020Applicants: University of Maryland, College Park, The United States of America as Represented by the Secretary of the ArmyInventors: Matthew D. WIDSTROM, Peter KOFINAS, Arthur V. CRESCE, Kang XU
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Patent number: 10392646Abstract: The present invention relates to a biosensor capable of measuring the total concentration of one or a plurality of amino acids with the use of a reagentless system comprising an electrode modified by hydrogel that comprises at least one enzyme that oxidizes at least one substrate that is at least one amino acid. In some embodiments, the biosensor comprises a hydrogel comprising alginate. In some embodiments, the biosensor comprises use of a thermophilic bacterial metabolic enzyme immobilized or attached to the hydrogel.Type: GrantFiled: October 17, 2013Date of Patent: August 27, 2019Assignees: University of Maryland, College Park, Children's National Medical Center, The United States of America, as Represented by The Secretary, Department of Health and Human ServicesInventors: Omar Bilal Ayyub, Adam Michael Behrens, Peter Kofinas, Marshall Lynn Summar, Juan Manuel Cabrera-Luque, Gary Cunningham, Anton Simeonov, Juan Marugan
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Publication number: 20180284099Abstract: The present disclosure relates to a biosensor capable of measuring the total concentration of one or a plurality of ammonia or ammonium ions with the use of indophenol reagents in the presence of an ionomer. In some embodiments, the biosensor comprises a perflurinated membrane that comprises an ionomer in contact with an alkali buffer in a vessel configured to receive a sample, such as whole blood. The disclosure also relates to a method of detecting or quantifying the ammonia or ammonium ion concentration in whole blood in a point of care bio sensor without reliance on gas chromatography or any measurement that takes more than about twenty minutes.Type: ApplicationFiled: March 23, 2018Publication date: October 4, 2018Applicants: University of Maryland, College Park, Children's National Medical Center, The United States Of America, As Represented By The Secretary, Dept. Of Health And Human ServicesInventors: Omar Bilal Ayyub, Adam Michael Behrens, Peter Kofinas, Marshall Lynn Summar, Juan Manuel Cabrera-Luque, Gary Cunningham, Anton Simeonov, Juan Marugan
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Publication number: 20180143210Abstract: The present disclosure relates to a biosensor capable of measuring the total concentration of one or a plurality of ammonia or ammonium ions with the use of indophenol reagents in the presence of an ionomer. In some embodiments, the biosensor comprises a perflurinated membrane that comprises an ionomer in contact with an alkali buffer in a vessel configured to receive a sample, such as whole blood. The disclosure also relates to a method of detecting or quantifying the ammonia or ammonium ion concentration in whole blood in a point of care bio sensor without reliance on gas chromatography or any measurement that takes more than about twenty minutes.Type: ApplicationFiled: April 27, 2016Publication date: May 24, 2018Applicants: University of Maryland, College Park, CHILDREN'S NATIONAL MEDICAL CENTERInventors: Omar Bilal Ayyub, Adam Michael Behrens, Peter Kofinas, Marshall Lynn Summar, II, Juan Manuel Cabrera-Luque, Gary Cunningham
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Patent number: 9952199Abstract: The present disclosure relates to a bio-sensor capable of measuring the total concentration of one or a plurality of ammonia or ammonium ions with the use of indophenol reagents in the presence of an ionomer. In some embodiments, the biosensor comprises a perflurinated membrane that comprises an ionomer in contact with an alkaline buffer in a vessel configured to receive a sample, such as whole blood. The disclosure also relates to a method of detecting or quantifying the ammonia or ammonium ion concentration in whole blood in a point of care biosensor without reliance on gas chromatography or any measurement that takes more than about twenty minutes.Type: GrantFiled: September 2, 2014Date of Patent: April 24, 2018Assignees: University of Maryland, College Park, Children's National Medical Center, The United States of America, As Represented By The Secretary, Dept. Of Health And Human ServicesInventors: Omar Bilal Ayyub, Adam Michael Behrens, Peter Kofinas, Marshall Lynn Summar, Juan Manuel Cabrera-Luque, Gary Cunningham, Anton Simeonov, Juan Marugan
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Patent number: 9863886Abstract: A sensor system, and a method of detecting a target analyte, comprises a chemically functionalized block copolymer, and a target analyte. The block copolymer exhibits a color change in the visible spectrum upon exposure to the target analyte.Type: GrantFiled: July 21, 2015Date of Patent: January 9, 2018Assignees: University of Maryland, College Park, The United States of America as Represented by the Secretary of the ArmyInventors: Peter Kofinas, Omar B. Ayyub, Jennifer W. Sekowski, Ta-I Yang
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Patent number: 9775929Abstract: Compositions comprising biomedical polymers, and in particular unique blends of poly(lactic-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) are provided. Methods of forming polymer fibers using such compositions and solution blow spinning techniques are also provided, as well as methods of delivering the blow spun polymer fibers onto a surface (e.g., such as tissue for use as a surgical scaffold, sealant or tissue adhesive).Type: GrantFiled: April 13, 2015Date of Patent: October 3, 2017Assignees: University of Maryland College Park, Children's National Medical CenterInventors: Adam Behrens, Peter Kofinas, Michael Sikorski, Anthony Sandler, Priya Srinivasan, Nora Lee
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Publication number: 20170198329Abstract: The present disclosure relates to a biosensor capable of measuring the total concentration of one or a plurality of amino acids with the use of a reaction surface comprising one or a plurality of metabolic enzymes or functional fragments thereof, but wherein the reaction surface does not comprise an electrode or electrically conductive support. In some embodiments, the biosensor comprises use of a thermophilic bacterial metabolic enzyme immobilized or attached to the reaction surface.Type: ApplicationFiled: April 17, 2015Publication date: July 13, 2017Applicant: University of Maryland, College ParkInventors: Omar Bilal AYYUB, Brian Theodore HELIGMAN, Peter KOFINAS, Marshall Lynn SUMMAR, Juan Manuel CABRERA-LUQUE, Gary Cunningham
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Publication number: 20160231310Abstract: The present disclosure relates to a bio-sensor capable of measuring the total concentration of one or a plurality of ammonia or ammonium ions with the use of indophenol reagents in the presence of an ionomer. In some embodiments, the biosensor comprises a perflurinated membrane that comprises an ionomer in contact with an alkaline buffer in a vessel configured to receive a sample, such as whole blood. The disclosure also relates to a method of detecting or quantifying the ammonia or ammonium ion concentration in whole blood in a point of care biosensor without reliance on gas chromatography or any measurement that takes more than about twenty minutes.Type: ApplicationFiled: September 2, 2014Publication date: August 11, 2016Inventors: Omar Bilal AYYUB, Adam Michael BEHRENS, Peter KOFINAS, Marshall Lynn SUMMAR, Juan Manuel CABRERA-LUQUE, Gary CUNNINGHAM, Anton SIMEONOV, Juan MARUGAN
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Publication number: 20160168613Abstract: The present invention relates to a biosensor capable of measuring the total concentration of one or a plurality of amino acids with the use of a reagentless system comprising an electrode modified by hydrogel that comprises at least one enzyme that oxidizes at least one substrate that is at least one amino acid. In some embodiments, the biosensor comprises a hydrogel comprising alginate. In some embodiments, the biosensor comprises use of a thermophilic bacterial metabolic enzyme immobilized or attached to the hydrogel.Type: ApplicationFiled: October 17, 2013Publication date: June 16, 2016Inventors: Omar Bilal Ayyub, Adam Michael Behrens, Peter Kofinas, Marshall Lynn Summar, Juan Manuel Cabrera-Luque, Gary Cunningham, Anton Simeonov, Juan Marugan
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Patent number: 9252456Abstract: A flexible polymer solid electrolyte material useful in battery technology is described. The flexible solid electrolyte comprises a first block that has the ability to solvate alkali metal salts. The flexible solid electrolyte comprises a second block that has the ability to incorporate lithium ions within microphase separated spherical domains, wherein the lithium ions are from a secondary lithium source. The flexible solid electrolyte further comprises a second lithium salt.Type: GrantFiled: March 1, 2010Date of Patent: February 2, 2016Assignee: University of Maryland, College ParkInventors: Peter Kofinas, Ayan Ghosh
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Publication number: 20160018337Abstract: A sensor system, and a method of detecting a target analyte, comprises a chemically functionalized block copolymer, and a target analyte. The block copolymer exhibits a color change in the visible spectrum upon exposure to the target analyte.Type: ApplicationFiled: July 21, 2015Publication date: January 21, 2016Applicants: University of Maryland, College Park, The United States of America as Represented by the Secretary of the ArmyInventors: Peter Kofinas, Omar B. Ayyub, Jennifer W. Sekowski, Ta-I Yang
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Publication number: 20150290356Abstract: Compositions comprising biomedical polymers, and in particular unique blends of poly(lactic-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) are provided. Methods of forming polymer fibers using such compositions and solution blow spinning techniques are also provided, as well as methods of delivering the blow spun polymer fibers onto a surface (e.g., such as tissue for use as a surgical scaffold, sealant or tissue adhesive).Type: ApplicationFiled: April 13, 2015Publication date: October 15, 2015Applicants: CHILDREN'S NATIONAL MEDICAL CENTER, UNIVERSITY OF MARYLAND, COLLEGE PARKInventors: Adam Behrens, Peter Kofinas, Michael Sikorski, Anthony Sandler, Priya Srinivasan, Nora Lee
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Patent number: 9115240Abstract: A sensor system, and a method of detecting a target analyte, comprises a chemically functionalized block copolymer, and a target analyte. The block copolymer exhibits a color change in the visible spectrum upon exposure to the target analyte.Type: GrantFiled: May 31, 2012Date of Patent: August 25, 2015Assignees: University of Maryland, College Park, The United States of America as Represented by the Secretary of the ArmyInventors: Peter Kofinas, Omar B. Ayyub, Jennifer W. Sekowski, Ta-I Yang