Patents by Inventor Peter Kolbeck

Peter Kolbeck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Coxsackie virus vectors for delivery of nucleic acids encoding antigenic or therapeutic products
    Patent number: 6323024
    Abstract: The present invention is drawn to the use of attenuated Coxsackievirus cardiotropic virus vectors as efficient gene transfer vectors to deliver immunomodulatory or other biologically active proteins and/or antigenic epitopes in transient infections to aid in preventing, ameliorating, and/or ablating infectious viral heart disease and reducing, or ablating entirely, heart transplant rejection. Additionally, other organs or tissues may be targeted with specific picornaviruses. In particular, an attenuated CVB3 viral vector able to express a cytokine is provided. This cytokine-expressing viral vector is able to deliver the cytokine to a target tissue and reduce disease symptoms.
    Type: Grant
    Filed: March 27, 2000
    Date of Patent: November 27, 2001
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Steven M. Tracy, Nora M. Chapman, Peter Kolbeck, James M. Malone, III
  • Coxsackie virus as a vector for delivery of anti-inflammatory cytokines
    Patent number: 6071742
    Abstract: The present invention is drawn to the use of artificially attenuated Coxsackievirus B3 cardiotropic virus vectors as efficient gene transfer vectors to deliver immunomodulatory proteins and/or antigenic epitopes in transient infections to aid in preventing, ameliorating, and/or ablating infectious viral heart disease and reducing, or ablating entirely, heart transplant rejection. Additionally, other organs or tissues may be targeted with specific picornaviruses. An attenuated CVB3 viral vector able to express a cytokine is provided.
    Type: Grant
    Filed: March 5, 1997
    Date of Patent: June 6, 2000
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Steven M. Tracy, Nora M. Chapman, Peter Kolbeck, James Malone