Patents by Inventor Peter Kremminger
Peter Kremminger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9382278Abstract: The present invention relates to a novel process for preparing ceftaroline fosamil via intermediates of Formulae (1), (3) or (4) of this process.Type: GrantFiled: September 24, 2015Date of Patent: July 5, 2016Assignee: Sandoz AGInventors: Peter Kremminger, Hubert Sturm
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Publication number: 20160009745Abstract: The present invention relates to a novel process for preparing ceftaroline fosamil via intermediates of Formulae (1), (3) or (4) of this process.Type: ApplicationFiled: September 24, 2015Publication date: January 14, 2016Applicant: Sandoz AGInventors: Peter Kremminger, Hubert Sturm
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Patent number: 9169239Abstract: The present invention relates to a novel process for preparing ceftaroline fosamil as well as to intermediates of Formulae (1), (3) or (4) of this process.Type: GrantFiled: September 7, 2012Date of Patent: October 27, 2015Assignee: Sandoz AGInventors: Peter Kremminger, Hubert Sturm
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Patent number: 9139597Abstract: The present invention relates to a method for the production of organic compounds, in particular sodium (6R,7R)-7-[(Z)-2-(5-amino-[1,2,4]thiadiazol-3-yl)-2-hydroxyimino-acetylamino]-8-oxo-3-[(E)-(R)-1?-(5-methyl-2-oxo-[1,3]-dioxol-4-ylmethoxycarbonyl)-2-oxo-[1,3?]bipyrrolidinyl-3-ylidenemethyl]-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate (ceftobiprole medocaril), and compounds of the general formula (1) and of the general formula (2), the compounds themselves and intermediates in the production according to the invention.Type: GrantFiled: May 25, 2010Date of Patent: September 22, 2015Assignee: SANDOZ AGInventors: Peter Kremminger, Johannes Ludescher, Hubert Sturm
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Patent number: 9096610Abstract: The present invention relates to a method for the production of organic compounds, in particular sodium (6R,7R)-7-[(Z)-2-(5-amino-[1,2,4]thiadiazol-3-yl)-2-hydroxyimino-acetylamino]-8-oxo-3-[(E)-(R)-1?-(5-methyl-2-oxo-[1,3]-dioxol-4-ylmethoxycarbonyl)-2-oxo-[1,3?]bipyrrolidinyl-3-ylidenemethyl]-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate (ceftobiprole medocaril), and compounds of the general formula (1) and of the general formula (2), the compounds themselves and intermediates in the production according to the invention.Type: GrantFiled: May 25, 2010Date of Patent: August 4, 2015Assignee: SANDOZ AGInventors: Peter Kremminger, Johannes Ludescher, Hubert Sturm
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Publication number: 20150073138Abstract: The present invention relates to a novel process for preparing ceftaroline fosamil as well as to a intermediates of this process.Type: ApplicationFiled: September 7, 2012Publication date: March 12, 2015Applicant: Sandoz AGInventors: Peter Kremminger, Hubert Sturm
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Patent number: 8288569Abstract: This invention relates to processes and intermediates for the stereoselective alkylation of carbonyl groups. The invention in particular allows the stereoselective preparation of the antidepressant drug escitalopram. It has been found that boric or boronic acid derivatives are useful bridging elements for the attachment of a chiral group to a compound containing a carbonyl group to be alkylated. The said borates and boronates are thus useful in a process for the asymmetric alkylation of a carbonyl group in a compound containing a carbonyl group and an anchor group capable of reacting with a boric or boronic acid derivative. The asymmetric alkylation can be carried out by admixing the compound containing a carbonyl group to be alkylated and the anchor group capable of reacting with a boric or boronic acid derivative with a boric or boronic acid derivative, adding a chiral alcohol, and adding an organometallic compound. After the alkylation reaction, the borate and boronate can be easily removed by hydrolysis.Type: GrantFiled: January 22, 2007Date of Patent: October 16, 2012Assignee: Sandoz AGInventors: Martin Albert, Hubert Sturm, Andreas Berger, Peter Kremminger
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Publication number: 20120116070Abstract: The present invention relates to a method for the production of organic compounds, in particular sodium (6R,7R)-7-[(Z)-2-(5-amino-[1,2,4]thiadiazol-3-yl)-2-hydroxyimino-acetylamino]-8-oxo-3-[(E)-(R)-1?-(5-methyl-2-oxo-[1,3]-dioxol-4-ylmethoxycarbonyl)-2-oxo-[1,3?]bipyrrolidinyl-3-ylidenemethyl]-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate (ceftobiprole medocaril), and compounds of the general formula (1) and of the general formula (2), the compounds themselves and intermediates in the production according to the invention.Type: ApplicationFiled: May 25, 2010Publication date: May 10, 2012Applicant: SANDOZ AGInventors: Peter Kremminger, Johannes Ludescher, Hubert Sturm
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Publication number: 20120108807Abstract: The present invention relates to a method for the production of organic compounds, in particular sodium (6R,7R)-7-[(Z)-2-(5-amino-[1,2,4]thiadiazol-3-yl)-2-hydroxyimino-acetylamino]-8-oxo-3-[(E)-(R)-1?-(5-methyl-2-oxo-[1,3]-dioxol-4-ylmethoxycarbonyl)-2-oxo-[1,3?]bipyrrolidinyl-3-ylidenemethyl]-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate (ceftobiprole medocaril), and compounds of the general formula (1) and of the general formula (2), the compounds themselves and intermediates in the production according to the invention.Type: ApplicationFiled: May 25, 2010Publication date: May 3, 2012Applicant: SANDOZ AGInventors: Peter Kremminger, Johannes Ludescher, Hubert Sturm
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Publication number: 20110009648Abstract: This invention relates to processes and intermediates for the stereoselective alkylation of carbonyl groups. The invention in particular allows the stereoselective preparation of the antidepressant drug escitalopram. It has been found that boric or boronic acid derivatives are useful bridging elements for the attachment of a chiral group to a compound containing a carbonyl group to be alkylated. The said borates and boronates are thus useful in a process for the asymmetric alkylation of a carbonyl group in a compound containing a carbonyl group and an anchor group capable of reacting with a boric or boronic acid derivative. The asymmetric alkylation can be carried out by admixing the compound containing a carbonyl group to be alkylated and the anchor group capable of reacting with a boric or boronic acid derivative with a boric or boronic acid derivative, adding a chiral alcohol, and adding an organometallic compound. After the alkylation reaction, the borate and boronate can be easily removed by hydrolysis.Type: ApplicationFiled: January 22, 2007Publication date: January 13, 2011Applicant: Sandoz AGInventors: Martin Albert, Hubert Sturm, Andreas Berger, Peter Kremminger
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Patent number: 7825241Abstract: 7-[2-(2-aminothiazol-4-yl)-2-(methylcarbonyloxyimino)acetamido]-3-vinyl-cephem-4-carboxylic acid of formula (I), in the form of a crystalline salt and use thereof, e.g. in the preparation of pure cefdinir. In another aspect this invention relates to the compound of formula (I) in the form of a salt, optionally in crystalline form, wherein the salt is selected from the group consisting of phosphate, hydrogen phosphate, mesylate, tosylate, sulfate, hydrogen sulfate and sulfamate.Type: GrantFiled: June 21, 2007Date of Patent: November 2, 2010Assignee: Sandoz AGInventors: Peter Kremminger, Siegfried Wolf, Johannes Ludescher
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Publication number: 20080081906Abstract: 7-[2-(2-aminothiazol-4-yl)-2-(methylcarbonyloxyimino)acetamido]-3-vinyl-cephem-4-carboxylic acid of formula (I), in the form of a crystalline salt and use thereof, e.g. in the preparation of pure cefdinir. In another aspect this invention relates to the compound of formula (I) in the form of a salt, optionally in crystalline form, wherein the salt is selected from the group consisting of phosphate, hydrogen phosphate, mesylate, tosylate, sulfate, hydrogen sulfate and sulfamate.Type: ApplicationFiled: June 21, 2007Publication date: April 3, 2008Inventors: Peter Kremminger, Siegfried Wolf, Johannes Ludescher
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Publication number: 20070249827Abstract: The present invention relates to the compound (4R,5S,6S)-(p-nitrobenzyl) 3-[[(3S,5S)-1(-p-nitrobenzyloxycarbonyl)-5-(dimethylaminocarbonyl)-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate in crystalline form, as well as a process for the production of this crystalline compound in alkyl alkanoates, and its usage in a process for producing meropenem.Type: ApplicationFiled: June 1, 2005Publication date: October 25, 2007Applicant: SANDOZ AGInventors: Peter Nadenik, Ole Storm, Peter Kremminger
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Patent number: 7250508Abstract: 7-[2-(2-aminothiazol-4-yl)-2-(methylcarbonyloxyimino)acetamido]-3-vinyl-cephem-4-carboxylic acid of formula I in the form of a crystalline salt and use thereof, e.g. in the preparation of pure cefdinir. In another aspect this invention relates to the compound of formula I in the form of a salt, optionally in crystalline form, wherein the salt is selected from the group consisting of phosphate, hydrogen phosphate, mesylate, tosylate, sulfate, hydrogen sulfate and sulfamate.Type: GrantFiled: August 12, 2003Date of Patent: July 31, 2007Assignee: Sandoz AGInventors: Peter Kremminger, Siegfried Wolf, Johannes Ludescher
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Publication number: 20060025586Abstract: 7-[2-(2-aminothiazol-4-yl)-2-(methylcarbonyloxyimino)acetamido]-3-vinyl-cephem-4-carboxylic acid of formula I in the form of a crystalline salt and use thereof, e.g. in the preparation of pure cefdinir. In another aspect this invention relates to the compound of formula I in the form of a salt, optionally in crystalline form, wherein the salt is selected from the group consisting of phosphate, hydrogen phosphate, mesylate, tosylate, sulfate, hydrogen sulfate and sulfamate.Type: ApplicationFiled: August 12, 2003Publication date: February 2, 2006Inventors: Peter Kremminger, Siegfried Wolf, Johannes Ludescher
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Patent number: 6894162Abstract: Cefuroxime in the form of a salt with n-butylamine; and its use for the production of cefuroxime axetil or for the production of the sodium salt of cefuroxime.Type: GrantFiled: September 10, 2001Date of Patent: May 17, 2005Assignee: Sandoz GmbHInventor: Peter Kremminger
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Patent number: 6787649Abstract: A process which comprises (i) acylating a compound of formula II with a compound of formula IV to obtain a compound of formula I and (ii) deformylating said compound of formula I to obtain a compound of formula IIIType: GrantFiled: February 12, 2003Date of Patent: September 7, 2004Assignee: Sandoz GmbHInventors: Peter Kremminger, Johannes Ludescher, Siegfried Wolf
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Publication number: 20030171577Abstract: Cefuroxime in the form of a salt with n-butylamine; and its use for the production of cefuroxime axetil or for the production of the sodium salt of cefuroxime.Type: ApplicationFiled: March 7, 2003Publication date: September 11, 2003Inventor: Peter Kremminger
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Publication number: 20030153748Abstract: A process and intermediates in the production of cefotiam (hexetil).Type: ApplicationFiled: February 12, 2003Publication date: August 14, 2003Inventors: Peter Kremminger, Johannes Ludescher, Siegfried Wolf
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Patent number: 6297282Abstract: The present application relates to compounds of formula (I) wherein A represents oxygen, sulfur or —NH—, m is 0-2, and R1, R2, R3, R6 and R7 have the meanings given in the specification, to a process for their preparation, as well as to their use in the inhibition of cyclooxygenase II.Type: GrantFiled: October 26, 1999Date of Patent: October 2, 2001Assignee: Nycomed Austria GmbHInventors: Michael Hartmann, Peter Kremminger, Heinz Blaschke, Dagmar Stimmeder, Harald Fellier, Franz Rovenszky