Patents by Inventor Peter Kretschmer
Peter Kretschmer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10266583Abstract: This disclosure relates to variant Factor VIII polypeptides comprising an amino acid substitution at one or more positions within one or both of the thrombin cleavage site and the activation loop. In certain embodiments, the variant Factor VIII polypeptide comprises one or more amino acid substitutions within both the thrombin cleavage site and the activation loop. In further embodiments, the variant factor VIII polypeptide further comprises one or more amino acid substitutions within the A1-A2 domain interface and the A2-A3 domain interface. The present disclosure further relates to methods of producing and/or using such variant Factor VIII polypeptides; nucleic acids encoding the polypeptides; vectors and/or recombinant cells, tissues, or organisms containing such nucleic acids; and kits and pharmaceutical compositions containing such polypeptides and/or nucleic acids.Type: GrantFiled: January 23, 2018Date of Patent: April 23, 2019Assignee: BAYER HEALTHCARE, LLCInventors: Uwe Gritzan, Peter Kretschmer, Lilley Leong, Chandra Patel
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Publication number: 20180148495Abstract: This disclosure relates to variant Factor VIII polypeptides comprising an amino acid substitution at one or more positions within one or both of the thrombin cleavage site and the activation loop. In certain embodiments, the variant Factor VIII polypeptide comprises one or more amino acid substitutions within both the thrombin cleavage site and the activation loop. In further embodiments, the variant factor VIII polypeptide further comprises one or more amino acid substitutions within the A1-A2 domain interface and the A2-A3 domain interface. The present disclosure further relates to methods of producing and/or using such variant Factor VIII polypeptides; nucleic acids encoding the polypeptides; vectors and/or recombinant cells, tissues, or organisms containing such nucleic acids; and kits and pharmaceutical compositions containing such polypeptides and/or nucleic acids.Type: ApplicationFiled: January 23, 2018Publication date: May 31, 2018Applicant: BAYER HEALTHCARE LLCInventors: Uwe GRITZAN, Peter KRETSCHMER, Lilley LEONG, Chandra PATEL
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Patent number: 9914764Abstract: This disclosure relates to variant Factor VIII polypeptides comprising an amino acid substitution at one or more positions within one or both of the thrombin cleavage site and the activation loop. In certain embodiments, the variant Factor VIII polypeptide comprises one or more amino acid substitutions within both the thrombin cleavage site and the activation loop. In further embodiments, the variant factor VIII polypeptide further comprises one or more amino acid substitutions within the A1-A2 domain interface and the A2-A3 domain interface. The present disclosure further relates to methods of producing and/or using such variant Factor VIII polypeptides; nucleic acids encoding the polypeptides; vectors and/or recombinant cells, tissues, or organisms containing such nucleic acids; and kits and pharmaceutical compositions containing such polypeptides and/or nucleic acids.Type: GrantFiled: March 14, 2014Date of Patent: March 13, 2018Assignee: BAYER HEALTHCARE, LLCInventors: Uwe Gritzan, Peter Kretschmer, Lilley Leong, Chandra Patel
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Publication number: 20160041999Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for analyzing queries. One of the methods includes obtaining a plurality of queries submitted from a plurality of different client devices; determining a source geographic location for each of the plurality of queries based on information associated with a client device from which the query was submitted; determining a destination geographic location for each of the plurality of queries based on the respective first text portion of the query; determining a vertical market category for each of the plurality of queries; receiving a request to analyze queries according to a first vertical market category and at least one of a source geographic location or a destination geographic location; using one or more indexes to identify queries responsive to the request; and presenting data describing the queries responsive to the request.Type: ApplicationFiled: July 23, 2012Publication date: February 11, 2016Applicant: GOOGLE INC.Inventors: Frederik Kemner, Jan Peter Kretschmer, Zoltan Szamonek
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Publication number: 20160031968Abstract: This disclosure relates to variant Factor VIII polypeptides comprising an amino acid substitution at one or more positions within one or both of the thrombin cleavage site and the activation loop. In certain embodiments, the variant Factor VIII polypeptide comprises one or more amino acid substitutions within both the thrombin cleavage site and the activation loop. In further embodiments, the variant factor VIII polypeptide further comprises one or more amino acid substitutions within the A1-A2 domain interface and the A2-A3 domain interface. The present disclosure further relates to methods of producing and/or using such variant Factor VIII polypeptides; nucleic acids encoding the polypeptides; vectors and/or recombinant cells, tissues, or organisms containing such nucleic acids; and kits and pharmaceutical compositions containing such polypeptides and/or nucleic acids.Type: ApplicationFiled: March 14, 2014Publication date: February 4, 2016Applicant: BAYER HEALTHCARE LLCInventors: Uwe GRITZAN, Peter KRETSCHMER, Lilley LEONG, Chandra PATEL
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Patent number: 8574594Abstract: The present invention relates to the generation of replication-competent viruses having therapeutic utility. The replication-competent viruses of the invention can express proteins useful in the treatment of disease.Type: GrantFiled: June 22, 2009Date of Patent: November 5, 2013Assignee: PsiOxus Therapeutics LimitedInventors: Terry Hermiston, Fang Jin, Peter Kretschmer
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Publication number: 20110217693Abstract: The present invention relates to the generation of replication-competent viruses having therapeutic utility. The replication-competent viruses of the invention can express proteins useful in the treatment of disease.Type: ApplicationFiled: June 22, 2009Publication date: September 8, 2011Applicant: BAYER SCHERING PHARMA AGInventors: Terry HERMISTON, Fang JIN, Peter KRETSCHMER
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Publication number: 20110020925Abstract: The present invention provides an improved, expression system for the regulated expression of an encoded protein or nucleic acid therapeutic molecule in the cells of a subject, for use in the treatment of disease. In particular, the present invention provides an improved, regulated gene expression system, and pharmaceutical compositions and uses thereof for treatment of disease.Type: ApplicationFiled: April 11, 2008Publication date: January 27, 2011Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFTInventors: Maxine Bauzon, Peter Droescher, Richard N. Harkins, Terry Hermiston, Peter Kretschmer, Konstantin Levitsky, Paul Szymanski
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Publication number: 20090208924Abstract: The present invention relates to the generation or replication-competent viruses having therapeutic utility. The replication-competent viruses of the invention can express proteins useful in the treatment of disease.Type: ApplicationFiled: November 28, 2005Publication date: August 20, 2009Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFTInventors: Terry Hermiston, Fang Jin, Peter Kretschmer
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Patent number: 7550296Abstract: The present invention relates to the generation of replication-competent viruses having therapeutic utility. The replication-competent viruses of the invention can express proteins useful in the treatment of disease.Type: GrantFiled: November 28, 2005Date of Patent: June 23, 2009Assignee: Bayer Schering Pharma AGInventors: Terry Hermiston, Fang Jin, Peter Kretschmer
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Publication number: 20080076729Abstract: The present invention provides an improved, expression system for the regulated expression of an encoded protein or nucleic acid therapeutic molecule in the cells of a subject, for use in the treatment of disease. In particular, the present invention provides an improved, regulated gene expression system, and pharmaceutical compositions and uses thereof for treatment of disease.Type: ApplicationFiled: April 4, 2007Publication date: March 27, 2008Inventors: Maxine Bauzon, Richard Harkins, Terry Hermiston, Peter Kretschmer, Paul Szymanski
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Publication number: 20070179113Abstract: The present invention provides an improved, expression system for the regulated expression of an encoded protein or nucleic acid therapeutic molecule in the cells of a subject, for use in the treatment of disease. In particular, the present invention provides an improved, regulated gene expression system, and pharmaceutical compositions and uses thereof for treatment of disease.Type: ApplicationFiled: April 4, 2007Publication date: August 2, 2007Inventors: Maxine Bauzon, Richard Harkins, Terry Hermiston, Peter Kretschmer, Harald Petry, Paul Szymanski
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Publication number: 20060292609Abstract: The present invention provides an improved, expression system for the regulated expression of an encoded protein or nucleic acid therapeutic molecule in the cells of a subject, for use in the treatment of disease. In particular, the present invention provides an improved, regulated gene expression system, and pharmaceutical compositions and uses thereof for treatment of disease.Type: ApplicationFiled: May 18, 2006Publication date: December 28, 2006Applicant: Schering AktiengesellschaftInventors: Maxine Bauzon, Richard Harkins, Terry Hermiston, Peter Kretschmer, Paul Szymanski
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Publication number: 20060281703Abstract: The present invention provides an improved, expression system for the regulated expression of an encoded protein or nucleic acid therapeutic molecule in the cells of a subject, for use in the treatment of disease. In particular, the present invention provides an improved, regulated gene expression system, and pharmaceutical compositions and uses thereof for treatment of disease.Type: ApplicationFiled: May 18, 2006Publication date: December 14, 2006Applicant: Schering AktiengesellschaftInventors: Maxine Bauzon, Richard Harkins, Terry Hermiston, Peter Kretschmer, Paul Szymanski
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Publication number: 20060188990Abstract: This invention provides novel transcriptional regulatory elements from the human TRPM4 (Transient Receptor Potential-Melastatin 4) gene. These promoter and enhancer elements preferentially activate transcription in prostate tumor cells and tissues as compared to other tissues. Methods and compositions are provided to employ TRPM4 promoter elements for prostate tumor-specific expression of therapeutic molecules. Prostate tumor-restricted replicating adenoviral vectors are also provided.Type: ApplicationFiled: April 16, 2003Publication date: August 24, 2006Applicant: Schering AktiengesellschaftInventors: Peter Kretschmer, Gordon Parry, Pamela Van Heuit, Ta-Tung Yuan
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Publication number: 20060121509Abstract: The present invention relates to the generation of replication-competent viruses having therapeutic utility.Type: ApplicationFiled: November 28, 2005Publication date: June 8, 2006Applicant: Schering AktiengesellschaftInventors: Terry Hermiston, Fang Jin, Peter Kretschmer
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Publication number: 20050234556Abstract: An intervertebral disk prosthesis includes a first anchoring device for anchoring the prosthesis to a first vertebral body and a second anchoring device for anchoring the prostheses to a second vertebral body. The two anchoring devices are moveably coupled to each other. The coupling between the two anchoring devices may include at least one deformable element. The coupling may be constructed as a single piece integrally with the first anchoring device and/or with the second anchoring device.Type: ApplicationFiled: April 8, 2005Publication date: October 20, 2005Inventor: Peter Kretschmer
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Patent number: 6921369Abstract: A mobile ergospirometry system including a portable measurement unit that can be attached to a subject and that incorporates a mouthpiece or mask to collect respiratory gas, a sensor for the volume or amount of gas as well as sensors to determine the CO2/O2 concentration in the respiratory gas, a signal processing unit, and a telemetry module. The system further includes a computer-assisted base station having a telemetry unit to create a wireless connection to the telemetry module. In the system a bidirectional transmission route to the telemetry unit is set up by the telemetry module to transmit data and commands, for which purpose a transmitter and receiver subassembly is provided in each case, so that from the base station it is possible to communicate to the subject online information or requirements for operation of the measurement unit and/or the progress of the test.Type: GrantFiled: September 21, 2000Date of Patent: July 26, 2005Assignee: Cortex Biophysik GmbHInventors: Matthias Gehrke, Ralf Henker, Claus-Peter Kretschmer, Thomas P. Kriesmer
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Patent number: 6858558Abstract: The invention relates to a catalyst component and a catalyst system for the preparation of high molecular weight ethylene or alpha-olefin homopolymers, ethylene-alpha-olefin copolymers, terpolymers or tetrapolymers, in a polymerization process, which is expediently effected in solution, at elevated temperature, preferably at least 80 DEG C. The catalyst system comprises a group 4-6 metal, preferably group 4 metal, a cyclic ligand (such as a cyclopentadienyl-type ligand), which forms a delocalized pi-bond with the metal M, a monohapto bonded 1,3-diaza-2-imino heterocyclic ligand (such as an iminoimidazolidine-type ligand) and anionic ligands and a catalyst activator coupound.Type: GrantFiled: March 5, 2002Date of Patent: February 22, 2005Assignee: Stichting Dutch Polymer InstituteInventor: Winfried Peter Kretschmer
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Publication number: 20040192541Abstract: The invention relates to a catalyst component and a catalyst system for the preparation of high molecular weight ethylene or alpha-olefin homopolymers, ethylene-alpha-olefin copolymers, terpolymers or tetrapolymers, in a polymerization process, which is expediently effected in solution, at elevated temperature, preferably at least 80 DEG C. The catalyst system comprises a group 4-6 metal, preferably group 4 metal, a cyclic ligand (such as a cyclopentadienyl-type ligand), which forms a delocalized pi-bond with the metal M, a monohapto bonded 1,3-diaza-2-imino heterocyclic ligand (such as an iminoimidazolidine-type ligand) and anionic ligands and a catalyst activator coupound.Type: ApplicationFiled: March 23, 2004Publication date: September 30, 2004Inventor: Winfried Peter Kretschmer