Abstract: A packaging system with a dual chamber configuration is described. The packaging system is comprised of a primary chamber and a secondary chamber, where the primary chamber and the secondary chamber are in or capable of being in fluidic communication by a channel. The secondary chamber has an upper layer and a lower layer, wherein the lower layer is of a material that opens in response to an applied force that the upper layer is able to withstand, whereupon a fluid, preferably a liquid, in the primary chamber can be dispensed from the packaging system. In one embodiment, the packaging system is integrated with a planar cartridge having one or more chambers for processing a sample for detection of an analyte.

Abstract: In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.

Abstract: In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.

Abstract: In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.

Abstract: A packaging system with a dual chamber configuration is described. The packaging system is comprised of a primary chamber and a secondary chamber, where the primary chamber and the secondary chamber are in or capable of being in fluidic communication by a channel. The secondary chamber has an upper layer and a lower layer, wherein the lower layer is of a material that opens in response to an applied force that the upper layer is able to withstand, whereupon a fluid, preferably a liquid, in the primary chamber can be dispensed from the packaging system. In one embodiment, the packaging system is integrated with a planar cartridge having one or more chambers for processing a sample for detection of an analyte.