Abstract: The present invention relates to a method of providing a FAS finding (30) for the functionality of an anorexigenic signal path for a patient, comprising the steps: providing a sample matrix (10) of a body substance of the patient, determining at least one first FAS indicator (11) from the sample matrix (10), determining at least one second FAS indicator (12) from the sample matrix (10), wherein the at least one second FAS indicator (12) is different from the at least one first FAS indicator (11), and generating the FAS finding (30) using an indicator spectrum (20) comprising the at least one first FAS indicator (11) and the at least one second FAS indicator (12). The invention also relates to an analysis device (100) for providing a FAS finding (30) with a computer program product according to the invention (90) and a storage means (80) with a computer program product (90) according to the invention stored thereon.

Abstract: The present invention relates to a method of providing an FAS finding (30) for the functionality of an anorexigenic signal path for a patient (1). Said method comprises the following steps: placing the patient (1) in a normalised preparation state in preparation for a normalised sample collection, providing a normalised sample matrix (10) collected from a patient (1) who was in the normalised preparation state, and determining at least one FAS indicator (11, 12, 13) from the normalised sample matrix (10), generating the FAS finding (30) based on the at least one determined FAS indicator (11, 12, 13).

Abstract: The disclosure is related to a method of treating a disorder, such as Prader Willi Syndrome (PWS), obesity or hyperphagia, in a subject using a melanocortin-4 receptor (MC4R) agonist. Also described is method of treating a subject having a deficiency in the pro-opiomelanocortin (POMC)-MC4R pathway, such as a POMC-null or a PC SK-null subject, using a MC4R agonist.

Abstract: The disclosure is related to a method of treating a disorder, such as Prader Willi Syndrome (PWS), obesity or hyperphagia, in a subject using a melanocortin-4 receptor (MC4R) agonist. Also described is method of treating a subject having a deficiency in the pro-opiomelanocortin (POMC)-MC4R pathway, such as a POMC-null or a PCSK-null subject, using a MC4R agonist.

Abstract: The invention relates to a Melanocortin-4 receptor (MC4R) agonist that exhibits greater induction of NFAT signaling compared to ?-MSH for use in the treatment and/or prevention of a medical condition associated with MC4R deficiency in a subject having an MC4R deficiency associated with impaired Nuclear factor of activated T-cells (NFAT) signaling.

Abstract: The disclosure is related to a method of treating a disorder, such as Prader Willi Syndrome (PWS), obesity or hyperphagia, in a subject using a melanocortin-4 receptor (MC4R) agonist. Also described is method of treating a subject having a deficiency in the pro-opiomelanocortin (POMC)-MC4R pathway, such as a POMC-null or a PCSK-null subject, using a MC4R agonist.