Patents by Inventor Peter Kumpalume

Peter Kumpalume has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds for affinity chromatography and for extending the half-life of a therapeutic agent
    Patent number: 9938243
    Abstract: Compounds useful for affinity chromatography as presented, more particularly for use in affinity chromatography to purify serum albumin, especially human serum albumin (HSA) and fusion proteins thereof. Methods for extending the half-life of therapeutic agents are also presented, particularly therapeutic peptide agents and small molecules, such as by conjugation of compounds described herein to the therapeutic peptide or small molecule, which, upon administration, binds to HSA, thereby providing a prolonged release of the therapeutic agent.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: April 10, 2018
    Assignee: GlaxoSmithKline Intellectual Property Development Limited
    Inventors: Peter Kumpalume, Oliver Schon, Christine Patricia Donahue, Ghotas Evindar, David I. Israel, David Paolella, Letian Kuai, Ninad V. Prabhu
  • COMPOUNDS FOR AFFINITY CHROMATOGRAPHY AND FOR EXTENDING THE HALF-LIFE OF A THERAPEUTIC AGENT
    Publication number: 20170369448
    Abstract: Compounds useful for affinity chromatography as presented, more particularly for use in affinity chromatography to purify serum albumin, especially human serum albumin (HSA) and fusion proteins thereof. Methods for extending the half-life of therapeutic agents are also presented, particularly therapeutic peptide agents and small molecules, such as by conjugation of compounds described herein to the therapeutic peptide or small molecule, which, upon administration, binds to HSA, thereby providing a prolonged release of the therapeutic agent.
    Type: Application
    Filed: September 7, 2017
    Publication date: December 28, 2017
    Inventors: Peter KUMPALUME, Oliver SCHON, Christine Patricia DONAHUE, Ghotas EVINDAR, David I. ISRAEL, David PAOLELLA, Letian KUAI, Ninad V. PRABHU
  • Compounds for affinity chromatography and for extending the half-life of a therapeutic agent
    Patent number: 9809558
    Abstract: Compounds useful for affinity chromatography as presented, more particularly for use in affinity chromatography to purify serum albumin, especially human serum albumin (HSA) and fusion proteins thereof. Methods for extending the half-life of therapeutic agents are also presented, particularly therapeutic peptide agents and small molecules, such as by conjugation of compounds described herein to the therapeutic peptide or small molecule, which upon administration, binds to HSA, thereby providing a prolonged release of the therapeutic agent.
    Type: Grant
    Filed: October 1, 2014
    Date of Patent: November 7, 2017
    Assignee: GlaxoSmithKline Intellectual Property Development Limited
    Inventors: Peter Kumpalume, Oliver Schon, Christine Patricia Donahue, Ghotas Evindar, David I. Israel, David Paolella, Letian Kuai, Ninad V. Prabhu
  • COMPOUNDS FOR AFFINITY CHROMATOGRAPHY AND FOR EXTENDING THE HALF-LIFE OF A THERAPEUTIC AGENT
    Publication number: 20160221962
    Abstract: Compounds useful for affinity chromatography as presented, more particularly for use in affinity chromatography to purify serum albumin, especially human serum albumin (HSA) and fusion proteins thereof. Methods for extending the half-life of therapeutic agents are also presented, particularly therapeutic peptide agents and small molecules, such as by conjugation of compounds described herein to the therapeutic peptide or small molecule, which, upon administration, binds to HSA, thereby providing a prolonged release of the therapeutic agent.
    Type: Application
    Filed: October 1, 2014
    Publication date: August 4, 2016
    Inventors: Peter KUMPALUME, Oliver SCHON, Christine Patricia DONAHUE, Ghotas EVINDAR, David I. ISRAEL, David PAOLELLA, Letian KUAI, Ninad V. PRABHU
  • METHOD OF PRODUCING A PROTEIN
    Publication number: 20150368292
    Abstract: The present invention relates to a method of producing a recombinant protein by harvesting a microbial cell broth and adding an amount of a flocculant to achieve an effective particle size distribution. The present invention also relates to a method of clarifying a microbial harvest by adding an amount of a flocculant to achieve an effective particle size distribution.
    Type: Application
    Filed: January 29, 2014
    Publication date: December 24, 2015
    Applicant: GLAXO GROUP LIMITED
    Inventors: Alex CHATEL, Michael HOARE, Peter KUMPALUME, Jessica Rachel MOLEK, Jason Michael RECK, Andrew David WEBER
  • Method for the isolation of haptoglobin
    Patent number: 9145448
    Abstract: The invention provides a method for the isolation of haptoglobin from a sample comprising Cohn fraction V, wherein said method comprises anion exchange chromatography of said sample. The product may be further purified and/or subjected to one or more virus inactivation or reduction steps. The isolated haptoglobin may then be formulated for pharmaceutical use.
    Type: Grant
    Filed: October 19, 2005
    Date of Patent: September 29, 2015
    Assignee: BIO PRODUCTS LABORATORY LIMITED
    Inventors: Joan Dalton, Adrian Podmore, Peter Kumpalume
  • Method for the purification of alpha-1-antitrypsin
    Patent number: 8580931
    Abstract: The invention relates to methods for the isolation of AAT from solutions containing albumin and AAT using at least two separate metal chelate chromatography steps. The product may be further purified and/or subjected to one or more virus inactivation or reduction steps. The isolated AAT may then be formulated for pharmaceutical use.
    Type: Grant
    Filed: November 29, 2006
    Date of Patent: November 12, 2013
    Assignee: Bio Products Laboratory Limited
    Inventors: Peter Kumpalume, Adrian Podmore, Joan Dalton
  • METHOD FOR THE PURIFICATION OF ALPHA-1-ANTITRYPSIN
    Publication number: 20090292114
    Abstract: The invention relates to methods for the isolation of AAT from solutions containing albumin and AAT using at least two separate metal chelate chromatography steps. The product may be further purified and/or subjected to one or more virus inactivation or reduction steps. The isolated AAT may then be formulated for pharmaceutical use.
    Type: Application
    Filed: November 29, 2006
    Publication date: November 26, 2009
    Applicant: NHS Blood and Transplant
    Inventors: Peter Kumpalume, Adrian Podmore, Joan Dalton
  • METHOD FOR THE ISOLATION OF HAPTOGLOBIN
    Publication number: 20090281282
    Abstract: The invention provides a method for the isolation of haptoglobin from a sample comprising Cohn fraction V, wherein said method comprises anion exchange chromatography of said sample. The product may be further purified and/or subjected to one or more virus inactivation or reduction steps. The isolated haptoglobin may then be formulated for pharmaceutical use.
    Type: Application
    Filed: October 19, 2005
    Publication date: November 12, 2009
    Applicant: NHS BLOOD AND TRANSPLANT
    Inventors: Joan Dalton, Adrian Podmore, Peter Kumpalume