Abstract: An ampoule opener for safely and conveniently breaking the tips off elongated ampoules of varying sizes to make possible the extraction of the contents therefrom. The opener includes a housing having an opening formed on the front face thereof for insertion of an ampoule tip therethrough. A projection extending outwardly from the front face is disposed adjacent a lower edge of the opening and serves as a fulcrum upon which the ampoule neck is placed and about which torque is applied to snap off the ampoule tip at the neck when the end of the tip engages an internal bearing surface. A hood over the housing opening protects the user from any spray resulting from the breaking of the ampoule and an internal cavity collects the tips broken from the ampoules.