Abstract: A method and assay for screening for antimicrobial compound comprises contacting bacteria having a detectable concentration with a target compound and determining the effect of the target compound on the concentration of the bacteria. The effect of the compound is determined by measuring the concentration of the bacteria at a plurality of times after the bacteria is contacted with the candidate compound. The method incorporates an assay, such as an optical density assay, luciferase-based assay, or kinetic assay.

Abstract: This invention relates to a method for the prophylaxis of or reducing the severity of post-viral bacterial infection by administering a PDE 4-specific inhibitor prior to or during the course of a viral infection or thereafter during the course of the bacterial infection.

Abstract: This invention relates to a method for the prophylaxis of or reducing the severity of post-viral bacterial infection by administering a PDE 4-specific inhibitor prior to or during the course of a viral infection or thereafter during the course of the bacterial infection.

Abstract: A plug for sealing the open end of a tube located in an opening in a tube sheet of a heat exchanger is described along with a method of installing the plug. The plug is comprised of a generally cylindrical metallic body of ductile material that is inserted into the open end of the tube at the tube sheet. The body carries one or more resilient seal rings and has a longitudinally extending blind central opening in the body. A body of pressure transmitting material, such as polyethylene is located in the body and an explosive charge is located in a longitudinally extending central opening in the body of pressure transmitting material. The explosive charge, when detonated, expands the metallic body of the plug and the resilient seal ring into sealing engagement with the tube.

Abstract: A method of and apparatus for severing multiple concentric casing strings in an abandoned oil or gas well allowing the upper portion of the casing strings to be removed comprising positioning a container holding a sealed cylinder full of air at atmospheric pressure that is surrounded by a high velocity explosive in the casing at the location of the desired cut. Igniting the explosive at one end of the container so that the mixture detonates producing a shock wave and gas bubbles that travel downwardly progressively, collapsing the sealed cylinder and increasing the pressure of the air in the cylinder until the cylinder fails whereby pressurized air forced from the cylinder causes the shock wave and gas bubbles from the TNT, RDX, and aluminum mixture to move laterally and sever the casing strings.

Abstract: An improved system for underwater oxy-arc cutting of a work piece, and a unique cutting rod used in such cutting work. This rod has an outer ferrous metal tube which contains a metal liner, which liner may in turn be comprised of a plurality of metal wires spaced in a circular pattern along the inner circumference of the tube. Oxygen is passed through a central passageway within the tube near but less than at sonic flows to avoid arc bounce. DC current (200-400 amperes) flows between the rod and work piece to form an arc consuming the rod at a rate between about 0.09-0.20 inches per second. The cross-sectional areas of the tube and the wires are about equal and the central passageway is less than one-half of either the tube or wires in cross-sectional areas. The rod is made (non-thermic) by sealing the tube about the wires or by use of aluminum or copper wires. Optimized parameters in underwater cutting of the work piece is applied, i.e. cutting rate, oxygen consumption, current magnitude and rod consumption.