Abstract: The present invention provides a piercing member adapted for use with a flow channel. The piercing member has a penetrating member for piercing a solid closure, and is retained to the flow channel, but still allows fluid to flow through the flow channel while retained to the flow channel.

Abstract: A filter device or apparatus is provided for the separation of materials, especially biomaterials from a fluid sample, under a force such as centrifugation, positive pressure, vacuum, or gravity. The device comprises two or more in-line tubular elements, one or more of which is a module that houses a filter media. The elements have complementary connection structures (e.g., elastomeric seal, O-ring, threads, Luer fittings, compression fittings, bayonet fittings, snap fittings, and the like) such that they can be assembled or reassembled in a train to form a conduit structure for leak-proof passage of a fluid sample volume. The assembly can be disassembled for collection and processing of retentate and filtrate material resulting from the filtration.

Abstract: A cannula assembly adapted to pierce a solid or unslit closure is disclosed and includes a blunt cannula and a piercing member held in cooperation with or contained within the flow channel of the cannula. Generally, the piercing member includes a tip capable of piercing an unslit stopper or closure and a means to temporarily retain the piercing member from the cannula and prevent inadvertent disengagement of the piercing member from the blunt cannula.

Abstract: A pre-slit injection site includes a housing with a flow path therethrough. A first end of the housing carries a pre-slit septum. A second end of the housing carries a coupling component to adapt the site to standard vials. The coupling component, a vial adapter, includes an adapter spike with openings allowing for the drainage of fluid in the vial through the spike and into the injection site. The vial adapter is provided with a skirt housing unit which protects the adapter spike in manufacturing and use. The skirt housing unit also provides features to lockingly engage the adapter with injection site to standard vials, despite dimensional variations in vial closures. Another embodiment of the coupling component is a spike having a barb feature capable of insertion into a standard vial or port and resisting disengagement.A blunt cannula is usable with the injection site combined with the coupling components.

Abstract: A pre-slit injection site includes a housing with a flow path therethrough. A first end of the housing carries a pre-slit septum. A second end of the housing carries a coupling component to adapt the site to standard vials. The coupling component, a vial adapter, includes an adapter spike with openings allowing for the drainage of fluid in the vial through the spike and into the injection site. The vial adapter is provided with a skirt housing unit which protects the adapter spike in manufacturing and use. The skirt housing unit also provides features to lockingly engage the adapter with injection site to standard vials, despite dimensional variations in vial closures. Another embodiment of the coupling component is a spike having a barb feature capable of insertion into a standard vial or port and resisting disengagement.A blunt cannula is usable with the injection site combined with the coupling components.