Abstract: Technologies are provided for alignment of spatial transcriptome slides of biological tissue. The alignment of images and the coordinates of spots within transcriptome profiles of the biological tissue can utilize an alignment model that can be machine-learned and can receive both a displaced image to be aligned and a reference image as inputs. The alignment model may learn a diffeomorphic transformation between those images. Such a transformation can be readily applied to the alignment of the displaced image and to the alignment of the displaced coordinates of spots within the transcriptome profiles of transcriptome. In some cases, transcriptome data can be analyzed and cast in an image-like format, and can then be utilized as supplementary input to the alignment model. The alignment model can be trained in a tissue agnostic manner, such as by using synthetic images.

Abstract: Glass-based articles comprise stress profiles providing improved fracture resistance. The glass-based articles herein provide high fracture resistance after multiple drops.

Abstract: Disclosed herein is a method of enhancing the accuracy and/or sensitivity of ultrasound imaging in detecting a tumor in a subject. The method comprises administering to the subject an effective amount of a nanoparticle prior to the application of ultrasound to the subject. According to certain embodiments of the present disclosure, the nanoparticle is a magnetic nanoparticle, for example, a gold, silver, or iron oxide nanoparticle. Also disclosed herein are methods of treating a tumor in a subject by detecting the tumor via ultrasound with the aid of a nanoparticle, and then administering to the subject an anti-cancer treatment based on the location of the tumor revealed by the ultrasound image.

Abstract: A camera head of a dental camera for detecting caries in an interdental space has an illuminating device for illuminating a tooth adjacent to the interdental space, which includes an infrared light source. The camera head further includes optics which have an image plane and an object plane, wherein an image sensor is located in the image plane, and the object plane divides the space into two half spaces, wherein a first half space contains the optics and is located in front of the object plane, and a second half space is located behind the object plane, both as seen from the optics. The illuminating device and the optics are designed and arranged with respect to one another in such a way that the illuminating device is arranged in the first half space and infrared light exiting the illuminating device is aimed in the direction of the second half space.

Abstract: Systems and methods are provided for dynamically determining a static tip resistance of a dynamically-loaded component having a tip. One example method comprises receiving gauge data from one or more gauges associated with the component proximate the tip. The gauge data may represent measurements related to one or more impacts on the component. The example method may further comprise determining measured data and estimated data corresponding to the one or more impacts on the component based at least in part on the gauge data. Furthermore, the method may comprise performing an inversion to select the estimated data having the least amount of difference in comparison to the measured data. The method may also comprise determining the static tip resistance based at least in part on the selected estimated data.

Abstract: Architecture that enhances the visual experience of a slide presentation by animating slide content as “actors” in the same background “scene”. This is provided by multi-layered transitions between slides, where a slide is first separated into “layers” (e.g., with a level of transparency). Each layer can then be transitioned independently. All layers are composited together to accomplish the end effect. The layers can comprise one or more content layers, and a background layer. The background layer can further be separated into a background graphics layer and a background fill layer. The transition phase can include a transition effect such as a fade, a wipe, a dissolve effect, and other desired effects. To provide the continuity and uniformity of presentation the content on the same background scene, a transition effect is not applied to the background layer.

Abstract: A source-matching service may gather information from one or more interest resources, then process the information to generate a set of keywords corresponding to an item or type of item in which users of a network-based service may be interested. Optionally, the source-matching service may identify a source to provide an item described by the interest keywords through the network-based service, and offer the source the opportunity to provide the item described by the interest keywords through the network-based service.

Abstract: A discharge method discharges an at least partially flexible container without contamination. The container (1) is discharged into a base body (10). A liner (20) encloses a filling opening (11) of the base body (10) and is secured to the base body (10). A filling end (21) of the liner (20) is folded inwards such that a receiving region forms for the container (1). The receiving region is sealed such that a discharge opening formed by a knife (15) allows the container (1) to be discharged while being completely sealed off to the exterior.

Abstract: Methods for reducing the growth of breast cancer cells in a subject by exposing the cells to nanoparticles, and irradiating with a focused, low to medium power ultrasound. The nanoparticles can be gold or magnetic nanoparticles. The nanoparticles can have a cancer drug attached, such as an antibody-based cancer drug.

Abstract: A method of customizing offers for sales of combinations of virtual items at discounted prices is disclosed. A combination of virtual items of a computer-implemented game is selected such that the sum of the values of each of the combination of virtual items has a proportion to an amount of currency in an account of a user of the computer-implemented game, the selecting being performed by a processor. An offer for a sale of the combination of the virtual items at a discounted price is generated for the user of the computer-implemented game. The offer for the sale of the combination of virtual items at the discounted price is presented to the user.

Abstract: A lock system includes a first lock and a second lock each with two profile strips operable for engagement with an at least partially flexible bundle and effective to enable a connection of a first bundle with a second bundle in a closed docking position and for guidance of a flow in a flow direction through lock members from the first bundle into the second bundle in an open docking position. The second bundle provides the lock members facing toward the first bundle, which lock members in the open docking position engage the lock members of the first bundle and jointly with the lock members of the first bundle form a flow channel for flow in the flow direction. Additionally, a slider for connecting and separating such locks is provided.

Abstract: A dental camera system for creating an image of an object has a dental camera, which comprises a housing and optics arranged therein together with an image sensor. The dental camera system further comprises an evaluation unit which cooperates with the image sensor to capture the object. To achieve a dental camera system whereof the dental camera performs using optics without movable or controllable optical elements, it is provided for the optics to be plenoptic optics which are designed to determine a 4D light field when capturing the object and for the evaluation unit to be designed to calculate at least one representation of the captured object from the 4D light field.

Abstract: Techniques are disclosed for render documents that are in proprietary formats in a browser or mobile device. In one embodiment, a method comprises converting a plurality of resources in a document file into a plurality of files that are native to a browser. The method further comprises creating a style sheet based on the document file, wherein an aggregate of the plurality of files together with the style sheet are configured to cause the browser to render an appearance of the document file. The method further comprises generating, based on the document file, an invisible layer to be laid on the appearance, wherein the invisible layer enables actions to be performed on the document file. Among other advantages, embodiments disclosed herein provide the convenience of viewing and accessing documents regardless of whether a software or plug-in therefor is installed.

Abstract: Methods for reducing the growth of breast cancer cells in a subject by exposing the cells to nanoparticles, and irradiating with a focused, low to medium power ultrasound. The nanoparticles can be gold or magnetic nanoparticles. The nanoparticles can have a cancer drug attached, such as an antibody-based cancer drug.

Abstract: Methods for killing cancer cells and treating cancer in a subject by exposing the cells to nanoparticles, and irradiating with a focused, low to medium power ultrasound. The nanoparticles can be gold, iron oxide, copper, silver, polystyrene, PEG, or liposome nanoparticles. The nanoparticles can have a cancer drug attached, such as an antibody-based cancer drug.

Abstract: Techniques are disclosed for render documents that are in proprietary formats in a browser or mobile device. In one embodiment, a method comprises converting a plurality of resources in a document file into a plurality of files that are native to a browser. The method further comprises creating a style sheet based on the document file, wherein an aggregate of the plurality of files together with the style sheet are configured to cause the browser to render an appearance of the document file. The method further comprises generating, based on the document file, an invisible layer to be laid on the appearance, wherein the invisible layer enables actions to be performed on the document file. Among other advantages, embodiments disclosed herein provide the convenience of viewing and accessing documents regardless of whether a software or plug-in therefor is installed.

Abstract: A system and method for connecting two flexible containers is provided, in particular for the environmentally sealed connecting of two open ends of tubular films. The method has at least the following method steps of: everting a first open end of a first flexible container over a first ring; everting a second open end of a second flexible container over a second ring, subsequently inserting the first ring through the second ring into the inside of the second flexible container; subsequently aligning, in a parallel and coaxial relationship, the rings in relation to one another; and abutting the rings with the ends clamped in between them.

Abstract: Methods for killing cancer cells and treating cancer in a subject by exposing the cells to nanoparticles, and irradiating with a focused, low to medium power ultrasound. The nanoparticles can be gold, iron oxide, copper, silver, polystyrene, PEG, or liposome nanoparticles. The nanoparticles can have a cancer drug attached, such as an antibody-based cancer drug.

Abstract: The invention relates to a discharge method for discharging an at least partially flexible container without contamination, in which method the container (1) is discharged into a base body (10), a liner (20) that encloses a filling opening (11) of the base body (10) being secured to the base body (10). According to the invention, a filling end (21) of the liner (20) is folded inwards such that a receiving region forms for the container (1). The receiving region is sealed in such a manner that a discharge opening formed by means of a knife (15) allows the container (1) to be discharged whilst being completely sealed off to the exterior.