Abstract: The present disclosure relates to RNA particles for delivery of RNA to target tissues after administration, in particular after parenteral administration such as intramuscular, intravenous, subcutaneous or intratumoral administration, and compositions comprising such RNA particles. The present disclosure, in particular, relates to RNA particles comprising RNA, at least one cationic or cationically ionizable lipid or lipid-like material, and at least one cationic polymer, wherein the particles do not have a core-shell structure.

Abstract: The invention relates to a copolymer for galenic applications, having an acrylate backbone and sidearms, containing ?-hydroxycarboxylic acid groups. The invention further relates to the process of preparing the foregoing copolymer for galenic applications and its use thereof.

Abstract: A device for setting a movable furniture part received in a basic furniture structure by means of a guiding unit, with which the furniture part is movably guided in the basic furniture structure, the guiding unit including a movement rail, which is attached to the furniture part and is mounted displaceably with respect to a basic-structure rail, the device including a setting unit that is attached to a front-side end portion of the movement rail, which sets a stop position of the movement rail during closing movements with respect to the basic-structure rail.

Abstract: In a guide device for guiding a furniture part, in particular a drawer, an extractable or the like, which can be moved relative to a furniture body, having at least one guide unit which comprises a body rail which can be fastened on the furniture body, a central rail mounted displaceable relative to the body rail by a lower rail guide, and an extraction rail mounted displaceable relative to the central rail by an upper rail guide and is connectable to an extractable, lower rail support for supporting the central rail on the body rail being provided in addition to the lower rail guide, and upper rail support for supporting the extraction rail on the central rail being provided in addition to the upper rail guide, the lower rail support and the upper rail support are actively connected to one another.

Abstract: The Invention relates to a particulate system for use in diminishing cell growth, in particular the growth of cancer cells, comprising one or more water soluble lanthanide compounds that are embedded in a solid biodegradable polymer particle, the polymer being selected from the group consisting of polycarbonic acids, polylactic acids, polyglycolic acids, polypeptides or combinations thereof.

Abstract: A device for setting a movable furniture part received in a basic furniture structure by means of a guiding unit, with which the furniture part is movably guided in the basic furniture structure, the guiding unit including a movement rail, which is attached to the furniture part and is mounted displaceably with respect to a basic-structure rail, the device including a setting unit that is attached to a front-side end portion of the movement rail, which sets a stop position of the movement rail during closing movements with respect to the basic-structure rail.

Abstract: Pharmaceutical drug particles of small particle size are produced by combining a solvent-non-solvent precipitate with an in-situ spray drying process. A pharmaceutical drug is dispersed in a water-miscible solvent, in particular ethanol, and heated in an infeed line under pressure to above the boiling point of the solvent until the drug dissolves. This solution collides as a fine liquid jet with a fine water jet in a gas-permeated microreactor, and the fine mist so arising vaporises rapidly. The organic solvent vaporizes first, then the water. The water may contain surface modifiers.

Abstract: The present invention relates to a strategy for improving the permeability and solubility of pharmaceuticals, based on adding a chemically modified amino alkyl methacrylate copolymer E, wherein the chemical modification is the quaternization of a fraction of the existing amino alkyl groups.

Abstract: The invention relates to an oral multiparticle pharmaceutical dosage form in the form of a receptacle reducing the pH values of stomach, containing a plurality of pellets, particles, granules or agglomerates whose mean diameter ranges from 50 to 2500 ?n substentially consisting of a) an internal matrix layer containing an active agent which is neither peptide or protein, nor the derivatives or conjugates thereof, a lipophilic matrix whose melting point is greater than 37° C. and a polymer with mucoadhesive effect, b) an external film coating substentially consisting of a polymer or an anionic copolymer which is optionally formulated with conventional pharmaceutical additives, wherein the active agent has a water solubility according to DAB 10, of at least 30 volume parts of water for one part by weight of the active agent and is coated with the lipophilic matrix and said active agent-containing lipophilic matrix is coated with a matrix made of a polymer with mucoadhesive effect.

Abstract: The present invention relates to a lyophilized nanoemulsion comprising a lipophilic phase and one or more sucrose fatty acid esters, to the nanoemulsion which can be prepared from the lyophilized nanoemulsion by redispersion, and to a process for the preparation of the lyophilized nanoemulsion.

Abstract: Pharmaceutical drug particles of small particle size are produced by combining a solvent-non-solvent precipitate with an in-situ spray drying process. A pharmaceutical drug is dispersed in a water-miscible solvent, in particular ethanol, and heated in an infeed line under pressure to above the boiling point of the solvent until the drug dissolves. This solution collides as a fine liquid jet with a fine water jet in a gas-permeated microreactor, and the fine mist so arising vaporises rapidly. The organic solvent vaporizes first, then the water. The water may contain surface modifiers.

Abstract: The present invention provides a micelle comprising an amphiphilic block copolymer, said amphiphilic block copolymer consisting of (a) a hydrophobic polymer attached to the 5? end of a first nucleic acid molecule, wherein said first nucleic acid molecule is hybridized with a second nucleic acid molecule, wherein a targeting unit capable of selectively binding to a specific cell type and/or tissue is attached to the 5? end of said second nucleic acid molecule; and/or (b) a hydrophobic polymer attached to the 3? end of a first nucleic acid molecule, wherein said first nucleic acid molecule is hybridized with a second nucleic acid molecule, wherein a targeting unit capable of selectively binding to a specific cell type and/or tissue is attached to the 3? end of said second nucleic acid molecule.

Abstract: The invention relates to a piece of furniture and to a device for influencing the movement of furniture parts which can be moved with respect to one another, having a guide unit for guidance of a first furniture part on a second furniture part, and having a drive unit to move the first furniture part in a driven manner relative to the second furniture part, with the guide unit having a fixed rail, which is associated with the second furniture part, and a moving rail, which is associated with the first furniture part. A pulling-pushing element is provided in order to apply a drive effect from the drive unit to the first furniture part, guided on the fixed rail via guide means.

Abstract: The present invention relates to a lyophilised nanoemulsion comprising a lipophilic phase and one or more sucrose fatty acid esters, to the nanoemulsion which can be prepared from the lyophilised nanoemulsion by redispersion, and to a process for the preparation of the lyophilised nanoemulsion.

Abstract: The present invention relates to a strategy for improving the permeability and solubility of pharmaceuticals, based on adding a chemically modified amino alkyl methacrylate copolymer E, wherein the chemical modification is the quaternization of a fraction of the existing amino alkyl groups.

Abstract: The invention relates to a piece of furniture and to a device for influencing the movement of furniture parts which can be moved with respect to one another, having a guide unit for guidance of a first furniture part on a second furniture part, and having a drive unit by means of which the first furniture part can be moved, in a driven manner, relative to the second furniture part, with the guide unit having a fixed rail, which is associated with the second furniture part, and a moving rail, which is associated with the first furniture part. A pulling-pushing element is provided in order to apply a drive effect from the drive unit to the first furniture part, guided on the fixed rail via guide means.

Abstract: The invention relates to an oral multiparticle pharmaceutical dosage form in the form of a receptacle reducing the pH values of stomach, containing a plurality of pellets, particles, granules or agglomerates whose mean diameter ranges from 50 to 2500 ?n substentially consisting of a) an internal matrix layer containing an active agent which is neither peptide or protein, nor the derivatives or conjugates thereof, a lipophilic matrix whose melting point is greater than 37° C. and a polymer with mucoadhesive effect, b) an external film coating substentially consisting of a polymer or an anionic copolymer which is optionally formulated with conventional pharmaceutical additives, wherein the active agent has a water solubility according to DAB 10, of at least 30 volume parts of water for one part by weight of the active agent and is coated with the lipophilic matrix and said active agent-containing lipophilic matrix is coated with a matrix made of a polymer with mucoadhesive effect.

Abstract: The invention relates to a process for providing a stable crystalline form of a fine-milled salbutamol sulfate, which can be produced, stored and used while maintaining the aerodynamic properties required for inhalation thereof, which comprises the steps of

Abstract: In a conveying pump having a cylinder introducible into a reservoir and having a pump piston, whereby the conveyed medium is supplied via an ascending line to a discharge line, an ascending line formed of two sections adjustable relative to one another is provided. The ascending line can be locked at different heights to vary the length of the ascending line so that the conveying pump can be used for reservoirs of different heights without deteriorating the conveying capacity of the pump. This adaptation can be performed easily and quickly. In addition, the conveying pump can be taken apart and easily cleaned, and component parts can be easily replaced.