Patents by Inventor Peter Laurence Toogood

Peter Laurence Toogood has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRICYCLIC TETRAHYDROQUINOLINE ANTIBACTERIAL AGENTS
    Publication number: 20150111884
    Abstract: Described herein are antibacterial compounds of formula I, methods for making the compounds, pharmaceutical compositions containing the compounds and methods of treating bacterial infections utilizing the compounds and pharmaceutical composition.
    Type: Application
    Filed: December 23, 2014
    Publication date: April 23, 2015
    Inventors: Michael P. Curtis, Timothy Allan Johnson, Manjinder S. Lall, Peter Laurence Toogood, Joseph S. Warmus
  • Tricyclic tetrahydroquinoline antibacterial agents
    Patent number: 8952149
    Abstract: Described herein are antibacterial compounds of formula I, methods for making the compounds, pharmaceutical compositions containing the compounds and methods of treating bacterial infections utilizing the compounds and pharmaceutical composition.
    Type: Grant
    Filed: September 24, 2013
    Date of Patent: February 10, 2015
    Assignee: Zoetis LLC
    Inventors: Michael Curtis, Timothy Allan Johnson, Manjinder S. Lall, Peter Laurence Toogood, Joseph S. Warmus
  • TRICYCLIC TETRAHYDROQUINOLINE ANTIBACTERIAL AGENTS
    Publication number: 20140088093
    Abstract: Described herein are antibacterial compounds, methods for making the compounds, pharmaceutical compositions containing the compounds and methods of treating bacterial infections utilizing the compounds and pharmaceutical composition.
    Type: Application
    Filed: September 24, 2013
    Publication date: March 27, 2014
    Applicant: Zoetis LLC
    Inventors: Michael Curtis, Timothy Allan Johnson, Manjinder S. Lall, Peter Laurence Toogood, Joseph S. Warmus
  • 1,4-benzodiazepinone compounds and their use in treating cancer
    Patent number: 8604023
    Abstract: The invention provides a family of 1,4-benzodiazepinone compounds and methods for their use as therapeutic agents in treating cancer. Pharmaceutical compositions and methods of making the 1,4-benzodiazepinone compounds are provided.
    Type: Grant
    Filed: April 16, 2010
    Date of Patent: December 10, 2013
    Assignee: The Regents of the University of Michigan
    Inventors: Gary D. Glick, Clarke Bentley Taylor, Peter Laurence Toogood, Chad Alan Van Huis
  • Tricyclic tetrahydroquinoline antibacterial agents
    Patent number: 8420646
    Abstract: The present invention is directed to tricyclic tetrahydroquinoline compounds of formula I, and pharmaceutically acceptable salts thereof wherein the variables R1, R2, R3, R4, R5, R20 and X are as described herein and to pharmaceutical compositions thereof, that exhibit useful antibacterial activity against a wide range of human and veterinary pathogens.
    Type: Grant
    Filed: December 20, 2010
    Date of Patent: April 16, 2013
    Assignee: PAH P&U LLC
    Inventors: Michael Robert Barbachyn, Paul Joseph Dobrowolski, Alexander Ross Hurd, Dennis Joseph McNamara, John Raymond Palmer, Arthur Glenn Romero, J. Craig Ruble, Debra Ann Sherry, Lisa Marie Thomasco, Peter Laurence Toogood
  • 1,4-BENZODIAZEPINONE COMPOUNDS AND THEIR USE IN TREATING CANCER
    Publication number: 20120094982
    Abstract: The invention provides a family of 1,4-benzodiazepinone compounds and methods for their use as therapeutic agents in treating cancer. Pharmaceutical compositions and methods of making the 1,4-benzodiazepinone compounds are provided.
    Type: Application
    Filed: April 16, 2010
    Publication date: April 19, 2012
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Gary D. Glick, Clarke Bentley Taylor, Peter Laurence Toogood, Chad Alan Van Huis
  • Tricyclic Tetrahydroquinoline Antibacterial Agents
    Publication number: 20110092494
    Abstract: The invention includes tetrahydroquinoline and related compounds of formula I, and pharmaceutical compositions thereof, that exhibit useful antibacterial activity against a wide range of human and veterinary pathogens.
    Type: Application
    Filed: December 20, 2010
    Publication date: April 21, 2011
    Inventors: Michael Robert Barbachyn, J. Craig Ruble, Arthur Glenn Romero, Lisa Marie Thomasco, Alexander Ross Hurd, John Raymond Palmer, Peter Laurence Toogood, Dennis Joseph McNamara, Debra Ann Sherry, Paul Joseph Dobrowolski
  • Isethionate salt of a selective CDK4 inhibitor
    Patent number: 7863278
    Abstract: Disclosed are polymorphs of the isethionate salt of 6-acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one, which is a selective cyclin-dependent kinase 4 (CDK4) inhibitor useful for treating inflammation and cell proliferative diseases such as cancer and restenosis.
    Type: Grant
    Filed: September 26, 2007
    Date of Patent: January 4, 2011
    Assignee: Warner-Lambert CompanyLLC
    Inventors: Vladimir Genukh Beylin, Anthony Clyde Blackburn, David Thomas Erdman, Peter Laurence Toogood
  • TRICYCLIC TETRAHYDROQUINOLINE ANTIBACTERIAL AGENTS
    Publication number: 20100022524
    Abstract: The invention includes tetrahydroquinoline and related compounds of formula I, and pharmaceutical compositions thereof, that exhibit useful antibacterial activity against a wide range of human and veterinary pathogens.
    Type: Application
    Filed: August 28, 2009
    Publication date: January 28, 2010
    Inventors: Michael Robert Barbachyn, J. Craig Ruble, Arthur Glenn Romero, Lisa Marie Thomasco, Alexander Ross Hurd, John Raymond Palmer, Peter Laurence Toogood, Dennis Joseph McNamara, Debra Ann Sherry, Paul Joseph Dobrowolski
  • Antibacterial Agents
    Publication number: 20090275536
    Abstract: Described herein are antibacterial compounds, methods for making the compounds, pharmaceutical compositions containing the compounds and methods of treating bacterial infections utilizing the compounds and pharmaceutical composition.
    Type: Application
    Filed: July 15, 2009
    Publication date: November 5, 2009
    Inventors: Timothy A. Johnson, Dennis J. McNamara, Debra A. Sherry, Peter Laurence Toogood
  • Tricyclic tetrahydroquinoline antibacterial agents
    Patent number: 7605157
    Abstract: The invention includes tetrahydroquinoline and related compounds of formula I and pharmaceutical compositions thereof, that exhibit useful antibacterial activity again a wide range of human and veterinary pathogens
    Type: Grant
    Filed: March 7, 2007
    Date of Patent: October 20, 2009
    Assignee: Pharmacia & Upjohn Company LLC
    Inventors: Michael Robert Barbachyn, J. Craig Ruble, Arthur Glenn Romero, Lisa Marie Thomasco, Alexander Ross Hurd, John Raymond Palmer, Peter Laurence Toogood, Dennis Joseph McNamara, Debra Ann Sherry, Paul Joseph Dobrowolski
  • Antibacterial agents
    Patent number: 7557100
    Abstract: Described herein are antibacterial compounds, methods for making the compounds, pharmaceutical compositions containing the compounds and methods of treating bacterial infections utilizing the compounds and pharmaceutical composition.
    Type: Grant
    Filed: December 19, 2006
    Date of Patent: July 7, 2009
    Assignee: Pfizer Inc.
    Inventors: Timothy A. Johnson, Dennis J. McNamara, Debra A. Sherry, Peter Laurence Toogood
  • 2-(pyridin-2-ylamino)-pyrido[2,3, d]pyrimidin-7-ones
    Patent number: 7456168
    Abstract: The present invention provides substituted 2-aminopyridines useful in treating cell proliferative disorders. The novel compounds of the present invention are potent inhibitors of cyclin-dependent kinases 4 (cdk4).
    Type: Grant
    Filed: April 11, 2007
    Date of Patent: November 25, 2008
    Assignee: Warner-Lambert Company
    Inventors: Mark Barvian, Richard John Booth, John Quin, III, Joseph Thomas Repine, Derek J. Sheehan, Peter Laurence Toogood, Scott Norman Vanderwel, Hairong Zhou
  • Isethionate salt of a selective CKD4 inhibitor
    Patent number: 7345171
    Abstract: Disclosed are polymorphs of the isethionate salt of 6-acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one, which is a selective cyclin-dependent kinase 4 (CDK4) inhibitor useful for treating inflammation and cell proliferative diseases such as cancer and restenosis.
    Type: Grant
    Filed: July 6, 2004
    Date of Patent: March 18, 2008
    Assignee: Warner-Lambert Company LLC
    Inventors: Vladimar G. Beylin, Anthony Clyde Blackburn, David Thomas Erdman, Peter Laurence Toogood
  • Tricyclic tetrahydroquinoline antibacterial agents
    Patent number: 7208490
    Abstract: The invention includes tetrahydroquinoline and related compounds of formula I, and pharmaceutical compositions thereof, that exhibit useful antibacterial activity against a wide range of human and veterinary pathogens
    Type: Grant
    Filed: October 2, 2003
    Date of Patent: April 24, 2007
    Assignee: Pharmacia & Upjohn Company LLC
    Inventors: Michael Robert Barbachyn, Gordan L. Bundy, Paul Joseph Dobrowolski, Alexander Ross Hurd, Gary E. Martin, Dennis Joseph McNamara, John Raymond Palmer, Donna L. Romero, Arthur Glenn Romero, J. Craig Ruble, Debra Ann Sherry, Lisa Marie Thomasco, Peter Laurence Toogood
  • 2-(pyridin-2-ylamino)-pyrido [2,3-d]pyrimidin-7-ones
    Patent number: 7208489
    Abstract: The present invention provides substituted 2-aminopyridines useful in treating cell proliferative disorders.
    Type: Grant
    Filed: January 28, 2005
    Date of Patent: April 24, 2007
    Assignee: Warner-Lambert Company
    Inventors: Mark Barvian, Richard John Booth, John Quin, III, Joseph Thomas Repine, Derek J. Sheehan, Peter Laurence Toogood, Scott Norman Vanderwel, Hairong Zhou
  • Pteridinones as kinase inhibitors
    Patent number: 7169778
    Abstract: Disclosed are compounds of Formulae (Ia), (Ib), (Ic), (Id) wherein: W is NH, S, SO, or SO2; R2 is (un)substituted aryl, (un)substituted heteroaryl, or (un)substituted carbocycle or heterocycle; Q is hydrogen or lower alkyl; R4 and R6 are the same or different and represent hydrogen, halogen, lower alkyl, lower alkoxy, (un)substituted aryl, (un)substituted heteroaryl, (un)substituted arylalkyl or (un)substituted heteroarylalkyl; and R8 is hydrogen, lower alkyl or an (un)substituted carbocyclic group containing from 3–7 members, up to two of which members are optionally hetero atoms selected from oxygen and nitrogen; or R8 is (un)substituted aryl, (un)substituted heteroaryl, (un)substituted arylalkyl or (un)substituted heteroarylalkyl. These compounds are useful for treating cell proliferative disorders, such as cancer and restenosis. These compounds are potent inhibitors of cyclin-dependent kinases (cdks) and growth factor-mediated kinases.
    Type: Grant
    Filed: June 21, 2000
    Date of Patent: January 30, 2007
    Assignee: Warner-Lambert Company
    Inventors: William Alexander Denny, Gordon William Rewcastle, Ellen Dobrusin, James Bernard Kramer, Dennis Joseph McNamara, Howard Daniel Hollis Showalter, Peter Laurence Toogood
  • Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors
    Patent number: 7053070
    Abstract: Disclosed are compounds of the formula wherein R2, R5, R6, R7, and R8 are as defined herein. These compounds and their pharmaceutical compositions are useful for treating cell proliferative disorders, such as cancer and restenosis. These compounds are potent inhibitors of cdks and growth factor-mediated kinases.
    Type: Grant
    Filed: January 23, 2001
    Date of Patent: May 30, 2006
    Assignee: Warner-Lambert Company
    Inventors: Richard John Booth, Ellen Myra Dobrusin, Vara Prasad Venkata Nagendra Josyula, Dennis Joseph Mc Namara, Peter Laurence Toogood
  • Process for preparing single enantiomers of 5,5,5,5?,5?,5?-hexafluoroleucine and protected analogs
    Patent number: 6974879
    Abstract: A process for synthesizing L and D-5,5,5,5?,5?,5?-hexafluoroleucine and protected analogs is disclosed. These compounds have utility in the preparation of fluorous peptides and proteins, which display interesting and unusual properties including strong self-association and an affinity for lipid bilayers.
    Type: Grant
    Filed: August 3, 2004
    Date of Patent: December 13, 2005
    Assignee: Warner-Lambert Company
    Inventors: James T. Anderson, Edward Neil Marsh, Peter Laurence Toogood
  • 2-(Pyridin-2-ylamino)-pyrido[2,3-d]pyrimidin-7-ones
    Patent number: 6936612
    Abstract: The present invention provides substituted 2-aminopyridines useful in treating cell proliferative disorders.
    Type: Grant
    Filed: January 16, 2003
    Date of Patent: August 30, 2005
    Assignee: Warner-Lambert Company
    Inventors: Mark Barvian, Richard John Booth, John Quin, III, Joseph Thomas Repine, Derek J. Sheehan, Peter Laurence Toogood, Scott Norman Vanderwel, Hairong Zhou