Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: A system and method for facilitating contextual communications that includes creating a contextual resource that is initially associated with at least at first communication session; receiving an incoming communication request and establishing a second communication session; associating the second communication session with the contextual resource; setting contextual information of the contextual resource; performing at least one contextual communication action.

Abstract: An apparatus for delivery of a vascular arteriovenous graft comprises a tubular sleeve defining an interior lumen adapted for being slidably positioned over a tunneling instrument. Once the tunneling instrument has been advanced to a desired subcutaneous anatomical location the shaft is removed while the sleeve remains in the tissue. The sleeve has a linear slit extending from a proximal end to a point intermediate the length of the sleeve. The lumen receives the distal end of the graft and at least a portion of a cannulation chamber such that the end of the sleeve progressively expands along the slit to provide an enlarged diameter for accommodating the cannulation chamber. Longitudinal force to the sleeve during removal of the sleeve from the tissue secures the graft in the sleeve by radial compression of the sleeve for pulling the graft and the sleeve through the tunnel and deploying the vascular graft.

Abstract: A cannulation chamber is provided for use with an arteriovenous graft including a flexible conduit. The cannulation chamber comprises an elongated body defining an annular passageway having a longitudinal axis extending between a first end and a second end. The body receives and surrounds the conduit in the passageway. The body comprises a self-sealing material and a cannulation port that exposes the self-sealing material. A flexible resilient elongated back plate is embedded in the body of the cannulation chamber such that the back plate extends generally parallel with and may partially surround the passageway. The back plate is formed of a substantially rigid material such that when a needle is inserted through the cannulation port and the self-sealing material, the needle is inhibited or prevented from extending through the back plate.

Abstract: A separation system and method for separating one or more solid fossil fuels from a contaminated source in a liquid medium, the system including primary separation means and secondary separation means, the primary and secondary separation means being arranged to operate with liquid media of differing specific gravities.

Abstract: A separation system and method for separating one or more solid fossil fuels from a contaminated source in a liquid medium, the system including primary separation means and secondary separation means, the primary and secondary separation means being arranged to operate with liquid media of differing specific gravities.

Abstract: There is described a light, portable thicknessing machine for wood, which comprises a base part including a bed (1) over which wood to be thicknessed passes, and an upper housing (9) in which are mounted a cutter and feed rollers to advance the wood, the upper housing being slidingly supported on a number of pillars (4) extending upwardly from the base part (2). At least two oppositely disposed pillars (4) have mounted coaxially therein threaded shafts which engage with lugs fixed to upper housing (9), the lugs passing through longitudinal slots in the pillars (4). The threaded shafts are interconnected so that they rotate together, by means of sprockets at their lower ends engaging an endless chain (6) rotation of the shafts thus effecting vertical movement of the upper housing (9) to adjust the height of the cutter above the bed.

Abstract: A scoring blade operating in advance of the main blade of a tilting arbor saw is mounted to tilt with the main saw blade. Provision is made for adjusting the scoring blade laterally and vertically.