Patents by Inventor Peter Lichtlen
Peter Lichtlen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230203162Abstract: The present invention relates to a multispecific antibody comprising two antibody-based binding domains, which specifically binds to mesothelin (MSLN-BD); and at least one antibody-based binding domain, which specifically binds to CD3 (CD3-BD); wherein said multispecific antibody does not comprise an immunoglobulin Fc region polypeptide, and wherein each of said MSLN-BD binds to mesothelin (MSLN) with a monovalent dissociation constant (KD) in the range of from 0.5 to 20 nM, when measured by SPR. The present invention further relates to nucleic acid sequence(s) encoding said multispecific antibody, vector(s) comprising aid nucleic acid sequence(s), host cell(s) comprising said nucleic acid sequence(s) or said vector(s), and a method of producing said multispecific antibody. Additionally, the present invention relates to pharmaceutical compositions comprising said multispecific antibody and methods of use thereof.Type: ApplicationFiled: May 28, 2021Publication date: June 29, 2023Inventors: Peter LICHTLEN, David URECH, Christian HESS, Tea GUNDE, Alexandre SIMONIN, Stefan WARMUTH, Matthias BROCK, Bithi CHATTERJEE, Maria JOHANSSON, Daniel SNELL
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Patent number: 9683034Abstract: The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNF?, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNF?, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of TNF?-related disorders. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.Type: GrantFiled: March 8, 2016Date of Patent: June 20, 2017Assignee: ESBATech, an Alcon Biomedical Research Unit LLCInventors: Stefan Ewert, David Urech, Adrian Auf Der Maur, Alcide Barberis, Peter Lichtlen
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Patent number: 9512411Abstract: The present invention concerns an antibody specific for human ALK (Anaplastic Lymphoma Kinase), in particular a scFv, a nucleic acid sequence encoding it, its production and its use as a pharmaceutical or for diagnostic purposes. Said antibody is suitable for the local treatment of tumors, in particular glioblastoma.Type: GrantFiled: December 16, 2014Date of Patent: December 6, 2016Assignee: CELL MEDICA SWITZERLAND AGInventors: Adrian Auf Der Maur, Alcide Barberis, Peter Lichtlen
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Publication number: 20160185850Abstract: The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNF?, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNF?, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of TNF?-related disorders. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.Type: ApplicationFiled: March 8, 2016Publication date: June 30, 2016Inventors: Stefan Ewert, David Urech, Adrian Auf Der Maur, Alcide Barberis, Peter Lichtlen
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Patent number: 9315572Abstract: The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNF?, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNF?, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of TNF?-related disorders. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.Type: GrantFiled: February 20, 2014Date of Patent: April 19, 2016Assignee: ESBATech, an Alcon Biomedical Research, Unit LLCInventors: Stefan Ewert, Alcide Barberis, David M. Urech, Adrian Auf Der Maur, Peter Lichtlen
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Publication number: 20150203829Abstract: The present invention concerns an antibody specific for human ALK (Anaplastic Lymphoma Kinase), in particular a scFv, a nucleic acid sequence encoding it, its production and its use as a pharmaceutical or for diagnostic purposes. Said antibody is suitable for the local treatment of tumors, in particular glioblastoma.Type: ApplicationFiled: December 16, 2014Publication date: July 23, 2015Inventors: Adrian Auf Der Maur, Alcide Barberis, Peter Lichtlen
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Patent number: 8945563Abstract: The present invention concerns an antibody specific for human ALK (Anaplastic Lymphoma Kinase), in particular a scFv, a nucleic acid sequence encoding it, its production and its use as a pharmaceutical or for diagnostic purposes. Said antibody is suitable for the local treatment of tumors, in particular glioblastoma.Type: GrantFiled: January 31, 2011Date of Patent: February 3, 2015Assignee: Delenex Therapeutics AGInventors: Adrian Auf Der Maur, Alcide Barberis, Peter Lichtlen
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Patent number: 8936785Abstract: scFv antibodies which specifically bind selected antigens and are obtainable by a method comprising (i) selecting from a pool of soluble and stable antibody frameworks a soluble and stable framework matching best the framework of a non-human antibody against the antigen with a certain binding specificity, (ii) either providing said soluble and stable framework with CDRs that bind specifically to said antigen, or mutating the framework of said non-human antibody towards the sequence of said soluble and stable framework, to generate scFv antibodies, (iii) testing the generated antibody for solubility and stability, and testing the generated antibody for antigen binding, and (iv) selecting an scFV that is soluble, stable and binds to the antigen specifically. Also provided are pharmaceutical compositions comprising said scFv antibody, methods of treatment and diagnosis for diseases related to over expression of antigens that are specifically bound by said antibody.Type: GrantFiled: July 10, 2007Date of Patent: January 20, 2015Assignee: Esbatech, An Alcon Biomedical Research Unit, LLCInventors: Adrian Auf Der Maur, Alcide Barberis, David M. Urech, Peter Lichtlen
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Patent number: 8835571Abstract: A fatty acid derivative-polymer conjugate including a conjugate comprising a fatty acid derivative and an alkyl substituted polylactide compound is provided. A pharmaceutical composition comprising the conjugate is also provided.Type: GrantFiled: April 19, 2013Date of Patent: September 16, 2014Assignee: Sucampo AGInventors: Ryuji Ueno, Peter Lichtlen, Robert Gurny, Michael Möller
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Publication number: 20140234315Abstract: scFv antibodies which specifically bind selected antigens and are obtainable by a method comprising (i) selecting from a pool of soluble and stable antibody frameworks a soluble and stable framework matching best the framework of a non-human antibody against the antigen with a certain binding specificity, (ii) either providing said soluble and stable framework with CDRs that bind specifically to said antigen, or mutating the framework of said non-human antibody towards the sequence of said soluble and stable framework, to generate scFv antibodies, (iii) testing the generated antibody for solubility and stability, and testing the generated antibody for antigen binding, and (iv) selecting an scFV that is soluble, stable and binds to the antigen specifically. Also provided are pharmaceutical compositions comprising said scFv antibody, methods of treatment and diagnosis for diseases related to over expression of antigens that are specifically bound by said antibody.Type: ApplicationFiled: April 30, 2014Publication date: August 21, 2014Applicant: ESBATECH, an Alcon Biomedical Research Unit LLCInventors: Adrian Auf Der Maur, Alcide Barberis, David M. Urech, Peter Lichtlen
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Publication number: 20140171634Abstract: The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNF?, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNF?, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of TNF?-related disorders. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.Type: ApplicationFiled: February 20, 2014Publication date: June 19, 2014Applicant: ESBATech, an Alcon Biomedical Research Unit LLCInventors: Stefan Ewert, Alcide Barberis, David M. Urech, Adrian Auf Der Maur, Peter Lichtlen
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Patent number: 8691228Abstract: The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNF?, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNF?, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of TNF?-related disorders. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.Type: GrantFiled: December 7, 2012Date of Patent: April 8, 2014Assignee: ESBATech, an Alcon Biomedical Research Unit LLCInventors: Stefan Ewert, Alcide Barberis, David Urech, Adrian Auf Der Maur, Peter Lichtlen
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Publication number: 20130281637Abstract: A fatty acid derivative-polymer conjugate including a conjugate comprising a fatty acid derivative and an alkyl substituted polylactide compound is provided. A pharmaceutical composition comprising the conjugate is also provided.Type: ApplicationFiled: April 19, 2013Publication date: October 24, 2013Applicant: Sucampo AGInventors: Ryuji UENO, Peter LICHTLEN, Robert GURNY, Michael MOLLER
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Publication number: 20130281638Abstract: A tricycle compound-polymer conjugate including a conjugate comprising a tricyclo compound and an alkyl substituted polylactide compound is provided. A pharmaceutical composition comprising the conjugate is also provided.Type: ApplicationFiled: April 19, 2013Publication date: October 24, 2013Applicant: SUCAMPO AGInventors: Ryuji UENO, Peter LICHTLEN, Robert GURNY, Michael MOLLER
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Patent number: 8389693Abstract: The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNF?, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNF?, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of TNF?-related disorders. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.Type: GrantFiled: September 26, 2011Date of Patent: March 5, 2013Assignee: ESBATech, an Alcon Boimedical Research Unit, LLCInventors: Stefan Ewert, Alcide Barberis, David M. Urech, Adrian Auf Der Maur, Peter Lichtlen
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Publication number: 20120064077Abstract: The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNF?, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNF?, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of TNF?-related disorders. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.Type: ApplicationFiled: September 26, 2011Publication date: March 15, 2012Applicant: ESBATECH, AN ALCON BIOMEDICAL RESEARCH UNIT LLC.Inventors: Stefan Ewert, Alcide Barberis, David M. Urech, Adrian Auf Der Maur, Peter Lichtlen
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Patent number: 8067547Abstract: The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNF?, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNF?, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of TNF?-related disorders. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.Type: GrantFiled: June 6, 2006Date of Patent: November 29, 2011Assignee: ESBATech, an Alcon Biomedical Research Unit, LLCInventors: Stefan Ewert, Alcide Barberis, David M. Urech, Adrian Auf Der Maur, Peter Lichtlen
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Publication number: 20110159008Abstract: The present invention concerns an antibody specific for human ALK (Anaplastic Lymphoma Kinase), in particular a scFv, a nucleic acid sequence encoding it, its production and its use as a pharmaceutical or for diagnostic purposes. Said antibody is suitable for the local treatment of tumors, in particular glioblastoma.Type: ApplicationFiled: January 31, 2011Publication date: June 30, 2011Applicant: DELENEX THERAPEUTICS AGInventors: Adrian Auf Der Maur, Alcide Barberis, Peter Lichtlen
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Patent number: 7902340Abstract: The present invention concerns an antibody specific for human ALK (Anaplastic Lymphoma Kinase), in particular a scFv, a nucleic acid sequence encoding it, its production and its use as a pharmaceutical or for diagnostic purposes. Said antibody is suitable for the local treatment of tumors, in particular glioblastoma.Type: GrantFiled: April 27, 2007Date of Patent: March 8, 2011Assignee: Delenex Therapeutics AGInventors: Adrian Auf Der Maur, Alcide Barberis, Peter Lichtlen
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Publication number: 20110002927Abstract: The invention provides an antigen-binding polypeptide which is able to penetrate into the cartilage. The disclosed polypeptide, compositions and methods are suitable for the treatment, prevention and/or delay of progression of cartilage degeneration.Type: ApplicationFiled: February 5, 2009Publication date: January 6, 2011Applicant: Delenex Therapeutics AGInventors: David M Urech, Peter Lichtlen