Patents by Inventor Peter Liston

Peter Liston has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mammalian IAP gene family, primers, probes and detection methods
    Patent number: 7067281
    Abstract: Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; substantially pure polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to inhibit apoptosis. Also disclosed are conserved regions characteristic of the IAP family and primers and probes for the identification and isolation of additional IAP genes. In addition, methods for treating diseases and disorders involving apoptosis are provided.
    Type: Grant
    Filed: June 20, 2003
    Date of Patent: June 27, 2006
    Assignee: Aegera Therapeutics, Inc.
    Inventors: Robert G. Korneluk, Alexander E. MacKenzie, Stephen Baird, Peter Liston
  • Electronic commerce system including customized catalog having encoded information
    Publication number: 20060134077
    Abstract: The invention features methods for the treatment of diabetes by administering a IAP nucleic acid sequence to a subject. One method includes the steps of (a) providing one or more insulin-producing cells or one or more precursor cells capable of producing progeny cells that produce insulin; (b) transducing the cells with a nucleic acid sequence encoding an IAP polypeptide, the nucleic acid sequence positioned for expression of the IAP polypeptide in the cells, wherein expression of the IAP polypeptide increases survival of the cells relative to untreated control cells; and (c)transplanting the cells from step (b) that have been transduced with a nucleic acid sequence encoding an IAP polypeptide into the individual, wherein the cells produce insulin in amounts sufficient to treat diabetes in the individual.
    Type: Application
    Filed: January 9, 2003
    Publication date: June 22, 2006
    Inventors: Bruce Verchere, Rusung Tan, Peter Liston, Robert Korneluk
  • Mammalian IAP gene family, primers, probes, and detection methods
    Publication number: 20060127927
    Abstract: Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; substantially pure polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to inhibit apoptosis. Also disclosed are conserved regions characteristic of the IAP family and primers and probes for the identification and isolation of additional IAP genes. In addition, methods for treating diseases and disorders involving apoptosis are provided.
    Type: Application
    Filed: September 1, 2005
    Publication date: June 15, 2006
    Applicant: University of Ottawa
    Inventors: Robert Korneluk, Alexander MacKenzie, Stephen Baird, Peter Liston
  • XAF genes and polypeptides: methods and reagents for modulating apoptosis
    Publication number: 20060040862
    Abstract: The invention provides novel XAF nucleic acid sequences. Also provided are XAF polypeptides, anti-XAF antibodies, and methods for modulating apoptosis and detecting compounds which modulate apoptosis.
    Type: Application
    Filed: August 16, 2005
    Publication date: February 23, 2006
    Applicant: Aegera Therapeutics Inc.
    Inventors: Robert Korneluk, Katsuyuki Tamai, Peter Liston, Alexander MacKenzie
  • XAF genes and polypeptides: methods and reagents for modulating apoptosis
    Patent number: 6946544
    Abstract: The invention provides novel XAF nucleic acid sequences. Also provided are XAF polypeptides, anti-XAF antibodies, and methods for modulating apoptosis and detecting compounds which modulate apoptosis.
    Type: Grant
    Filed: November 5, 2002
    Date of Patent: September 20, 2005
    Assignee: Aegera Therapeutics Inc.
    Inventors: Robert G. Korneluk, Katsuyuki Tamai, Peter Liston, Alexander E. MacKenzie
  • Mammalian IAP gene family, primers, probes and detection methods
    Publication number: 20040157232
    Abstract: Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; substantially pure polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to inhibit apoptosis. Also disclosed are conserved regions characteristic of the IAP family and primers and probes for the identification and isolation of additional IAP genes. In addition, methods for treating diseases and disorders involving apoptosis are provided.
    Type: Application
    Filed: June 20, 2003
    Publication date: August 12, 2004
    Inventors: Robert G. Komeluk, Alexander E. MacKenzie, Stephen Baird, Peter Liston
  • Mammalian IAP gene family, primers, probes and detection methods
    Patent number: 6689562
    Abstract: Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; substantially pure polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to inhibit apoptosis. Also disclosed are conserved regions characteristic of the IAP family and primers and probes for the identification and isolation of additional IAP genes. In addition, methods for treating diseases and disorders involving apoptosis are provided.
    Type: Grant
    Filed: December 1, 1998
    Date of Patent: February 10, 2004
    Assignee: AEGERA Therapeutics Inc.
    Inventors: Robert G. Korneluk, Alexander E. MacKenzie, Stephen Baird, Peter Liston
  • Mammalian apoptosis inhibitor protein gene family, primers, probes and detection methods
    Patent number: 6656704
    Abstract: Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; substantially pure polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to inhibit apoptosis. Also disclosed are conserved regions characteristic of the IAP family and primers and probes for the identification and isolation of additional IAP genes. In addition, methods for treating diseases and disorders involving apoptosis are provided.
    Type: Grant
    Filed: September 14, 1998
    Date of Patent: December 2, 2003
    Assignee: Aegera Therapeutics Inc.
    Inventors: Robert G. Korneluk, Alexander E. MacKenzie, Stephen Baird, Peter Liston
  • XAF genes and polypeptides: methods and reagents for modulating apoptosis
    Publication number: 20030215824
    Abstract: The invention provides novel XAF nucleic acid sequences. Also provided are XAF polypeptides, anti-XAF antibodies, and methods for modulating apoptosis and detecting compounds which modulate apoptosis.
    Type: Application
    Filed: November 5, 2002
    Publication date: November 20, 2003
    Applicant: Aegera Therapeutics Inc.
    Inventors: Robert G. Korneluk, Katsuyuki Tamai, Peter Liston, Alexander E. MacKenzie
  • Methods and reagents for peptide-BIR interaction screens
    Publication number: 20030157522
    Abstract: The invention features a substantially pure polypeptide having a length of less than 100 amino acids and capable of forming a complex with a polypeptide that includes a BIR domain. The invention also features displacement assays in which the ability of a candidate compound to disrupt the interaction between a BIR domain-containing polypeptide and a polypeptide of the invention is indicative of the ability of the candidate compound to modulate IAP biological activity.
    Type: Application
    Filed: November 12, 2002
    Publication date: August 21, 2003
    Inventors: Alain Boudreault, Robert G. Korneluk, Eric LaCasse, Peter Liston
  • Mammalian IAP gene family, primers, probes and detection methods
    Patent number: 6541457
    Abstract: Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; substantially pure polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to inhibit apoptosis. Also disclosed are conserved regions characteristic of the IAP-family and primers and probes for the identification and isolation of additional IAP genes. In addition, methods for treating diseases and disorders involving apoptosis are provided.
    Type: Grant
    Filed: December 1, 1998
    Date of Patent: April 1, 2003
    Assignee: Aegera Therapeutics Inc.
    Inventors: Robert G. Korneluk, Alexander E. MacKenzie, Stephen Baird, Peter Liston
  • Method of identifying a compound that modulates XAF-mediated apoptosis
    Patent number: 6495339
    Abstract: The invention provides novel XAF nucleic acid sequences. Also provided are XAF polypeptides, anti-XAF antibodies, and methods for modulating apoptosis and detecting compounds which modulate apoptosis.
    Type: Grant
    Filed: July 14, 2000
    Date of Patent: December 17, 2002
    Assignee: Aegera Therapeutics Inc.
    Inventors: Robert G. Korneluk, Katsuyuki Tamai, Peter Liston, Alexander E. MacKenzie
  • MAMMALIAN IAP GENE FAMILY, PRIMERS, PROBES AND DETECTION METHODS
    Publication number: 20020187946
    Abstract: Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; substantially pure polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to inhibit apoptosis. Also disclosed are conserved regions characteristic of the IAP family and primers and probes for the identification and isolation of additional IAP genes. In addition, methods for treating diseases and disorders involving apoptosis are provided.
    Type: Application
    Filed: December 1, 1998
    Publication date: December 12, 2002
    Inventors: ROBERT G. KORNELUK, ALEXANDER E. MACKENZIE, STEPHEN BAIRD, PETER LISTON
  • Detection and modulation of IAPs and NAIP for the diagnosis and treatment of proliferative disease
    Publication number: 20020120121
    Abstract: Disclosed are diagnostic and prognostic kits for the detection and treatment of proliferative diseases such as ovarian cancer, breast cancer, and lymphoma. Also disclosed are cancer therapeutics utilizing IAP antisense nucleic acids IAP fragments, and antibodies which specifically bind IAP polypeptides.
    Type: Application
    Filed: October 9, 2001
    Publication date: August 29, 2002
    Inventors: Robert G. Korneluk, Alexander E. Mackenzie, Peter Liston, Stephen Baird, Benjamin K. Tsang, Christine Pratt
  • Modulation of IAPs for the diagnosis and antisense treatment of proliferative disease
    Patent number: 6300492
    Abstract: Disclosed are diagnostic and prognostic kits for the detection and treatment of proliferative diseases such as ovarian cancer, breast cancer, and lymphoma. Also disclosed are cancer therapeutics utilizing IAP antisense nucleic acids IAP fragments, and antibodies which specifically bind IAP polypeptides.
    Type: Grant
    Filed: July 14, 2000
    Date of Patent: October 9, 2001
    Assignee: Aegera Therapeutics Inc.
    Inventors: Robert G. Korneluk, Alexander E. Mackenzie, Peter Liston, Stephen Baird, Benjamin K. Tsang, Christine Pratt
  • XIAP IRES and uses thereof
    Patent number: 6171821
    Abstract: The invention features purified nucleic acid encoding a novel internal ribosome entry site (IRES) sequence from the X-linked inhibitor of apoptosis (XIAP) gene. The invention also features methods for using the XIAP IRES to increase cap-independent translation of polypeptide coding sequences linked to the XIAP IRES, and methods for isolating compounds that modulate cap-independent translation.
    Type: Grant
    Filed: June 14, 1999
    Date of Patent: January 9, 2001
    Assignee: Apoptogen, Inc.
    Inventors: Robert G. Korneluk, Martin Holcik, Peter Liston
  • XIAP IRES and uses thereof
    Patent number: 6159709
    Abstract: The invention features purified nucleic acid encoding a novel internal ribosome entry site (IRES) sequence from the X-linked inhibitor of apoptosis (XIAP) gene. The invention also features methods for using the XIAP IRES to increase cap-independent translation of polypeptide coding sequences linked to the XIAP IRES, and methods for isolating compounds that modulate cap-independent translation.
    Type: Grant
    Filed: July 24, 1998
    Date of Patent: December 12, 2000
    Assignee: Apoptogen, Inc.
    Inventors: Robert G. Korneluk, Martin Holcik, Peter Liston
  • Mammalian IAP gene family, primers, probes, and detection methods
    Patent number: 6156535
    Abstract: Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; substantially pure polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to inhibit apoptosis. Also disclosed are conserved regions characteristic of the IAP family and primers and probes for the identification and isolation of additional IAP genes. In addition, methods for treating diseases and disorders involving apoptosis are provided.
    Type: Grant
    Filed: December 22, 1995
    Date of Patent: December 5, 2000
    Assignee: University of Ottawa
    Inventors: Robert G. Korneluk, Alexander E. MacKenzie, Stephen Baird, Peter Liston
  • Modulation of IAPs for the treatment of proliferative diseases
    Patent number: 6133437
    Abstract: Disclosed are diagnostic and prognostic kits for the detection and treatment of proliferative diseases such as ovarian cancer, breast cancer, and lymphoma. Also disclosed are cancer therapeutics utilizing IAP antisense nucleic acids IAP fragments, and antibodies which specifically bind IAP polypeptides.
    Type: Grant
    Filed: February 13, 1997
    Date of Patent: October 17, 2000
    Assignee: Apoptogen, Inc.
    Inventors: Robert G. Korneluk, Alexander E. MacKenzie, Peter Liston, Stephen Baird, Benjamin K. Tsang, Christine Pratt
  • Detection and modulation of IAPS for the diagnosis and treatment of proliferative disease
    Patent number: 6107041
    Abstract: Disclosed are diagnostic and prognostic kits for the detection and treatment of proliferative diseases such as ovarian cancer, breast cancer, and lymphoma. Also disclosed are cancer therapeutics utilizing IAP antisense nucleic acids IAP fragments, and antibodies which specifically bind IAP polypeptides.
    Type: Grant
    Filed: December 16, 1998
    Date of Patent: August 22, 2000
    Assignee: Apoptogen, Inc.
    Inventors: Robert G. Korneluk, Alexander E. MacKenzie, Peter Liston, Stephen Baird, Benjamin K. Tsang, Christine Pratt