Abstract: Methods of treating headache with antipsychotics are provided. A kit for treating headache is also provided, comprising an antipsychotic and a device for rapid delivery of the antipsychotic.

Abstract: A machine for providing hot-in-place recycling and repaving of an existing asphalt-based pavement, in which the pavement is first heated. Using this machine the heated pavement surface is then scarified, and new aggregate is dispensed onto it, to form a recycled, preheated asphalt and aggregate mixture. This mixture is again heated and scarified to premix it, and a new pavement surface is now milled to grade and width by applying this mixture using a plurality of extension mills having a main frame. The pavement surface is then remilled to grade using a main mill. Rejuvenator fluid is introduced in the main mill of the machine, and mixed with the recycled asphalt and aggregate mxiture. Rejuvenator fluid is also introduced into a pug mill of the machine and again mixed with the recycled asphalt and aggregate mixture. The rejuvenator-enriched, recycled asphalt and aggregate windrow thus formed is then laid to grade using one or more screeds.

Abstract: The disclosure provides methods and compositions for providing an effective dose of an active agent and/or drug composition to a subject by inhalation. The methods of the disclosure are useful in determining a maximal effective dose that limits cardiovascular damage upon inhalation.

Abstract: Aerosol drug delivery devices incorporating percussively activated heat packages are disclosed. The heat packages include a percussive igniter and a fuel capable of undergoing an exothermic oxidation-reduction reaction when ignited by the percussive igniter. The drug delivery devices disclosed can be activated by an actuation mechanism to vaporize a thin solid film comprising a drug disposed on the exterior of a hat package. Metal coordination complexes of volatile drugs, and in particular nicotine, from which the drug can be selectively vaporized when heated are also disclosed. The use of aerosol drug delivery devices comprising thin films of nicotine metal salt complexes for the treatment of nicotine craving and for effecting smoking cessation are also disclosed.

Abstract: Percussive ignition systems and heat packages incorporating percussively igniter systems capable of being activated by inhalation are disclosed.

Abstract: A method for deploying a reconnaissance sonde, including the steps of: incorporating at least one environmental sensor and an associated communication device into a robust, aerodynamically efficient casing; deploying the sonde by imparting a spin and a directional velocity to the casing, sufficient to carry the sonde into a region of interest; and establishing communication with the communication device, thereby enabling data from the sensor(s) to be transmitted to a remote location. A sonde for remote data collection is also provided, including at least one environmental sensor, an energy source and communication means. The sonde is generally shaped as a discus or saucer, a clay pigeon or skeet, for deployment by applying a spin and directional velocity to the sonde.

Abstract: A process and device for the recycling of asphalt including at least one one preheater unit. The preheater having a heater, scarifying rakes, and a bin to dispense aggregate. Also include is a recycling machine having a heater, scarifying rakes, a plurality of extension mills, a main mill, as well as a pug mill having first and second downwardly rotating rotors, the pug mill mixes asphalt and liquid additives together to form a homogenous mix; and at least one screed for laying the homogeneously mixed asphalt to grade.

Abstract: A process and device for the recycling of asphalt including at least one one preheater unit. The preheater having a heater, scarifying rakes, and a bin to dispense aggregate. Also include is a recycling machine having a heater, scarifying rakes, a plurality of extension mills, a main mill, as well as a pug mill having first and second downwardly rotating rotors, the pug mill mixes asphalt and liquid additives together to form a homogenous mix; and at least one screed for laying the homogeneously mixed asphalt to grade.

Abstract: A process and device for the recycling of asphalt including at least one one preheater unit. The preheater having a heater, scarifying rakes, and a bin to dispense aggregate. Also include is a recycling machine having a heater, scarifying rakes, a plurality of extension mills, a main mill, as well as a pug mill having first and second downwardly rotating rotors, the pug mill mixes asphalt and liquid additives together to form a homogenous mix; and at least one screed for laying the homogeneously mixed asphalt to grade.

Abstract: A method for providing hot-in-place recycling and repaving of an existing asphalt-based pavement, in which the pavement is first heated. The heated pavement surface is then sacrified, and new aggregate is dispensed onto it, to form a recycled, preheated asphalt and aggregate mixture. This mixture is again heated and scarified to premix it, and a new pavement surface is now milled to grade and width by applying this mixture using a plurality of extension mills having a main frame. The pavement surface is then remilled to grade using a main mill. Rejuvenator fluid is introduced in the main mill, and mixed with the recycled asphalt and aggregate mixture. Rejuvenator fluid is also introduced into a pug mill and again mixed with the recycled asphalt and aggregate mixture. The rejuvenator-enriched, recycled asphalt and aggregate windrow thus formed is then laid to grade using one or more screeds.

Abstract: A process and device for the recycling of asphalt including at least one one preheater unit. The preheater having a heater, scarifying rakes, and a bin to dispense aggregate. Also include is a recycling machine having a heater, scarifying rakes, a plurality of extension mills, a main mill, as well as a pug mill having first and second downwardly rotating rotors, the pug mill mixes asphalt and liquid additives together to form a homogenous mix; and at least one screed for laying the homogeneously mixed asphalt to grade.

Abstract: An optical fibre bend sensor (10) measures the degree and orientation of bending present in a sensor length (30) portion of a fibre assembly (26). Within a multicored fibre (30, 32,34), cores (62, 66) are grouped in non-coplanar pairs. An arrangement of optical elements (28, 36, 38) define within each core pair (62, 66) two optical paths (122, 124) which differ along the sensor length (30): one core (62) of a pair (62, 66) is included in the first path (122), and the other core (66) in the second path (124). A general bending of the sensor region (30) will lengthen one core (62, 66) with respect to the other. Interrogation of this length differential by means of interferometry generates interferograms from which the degree of bending in the plane of the core pair is extracted. Bend orientation can be deduced from data extracted from multiple core pairs.

Abstract: Monoclonal antibodies to the CD25 antigen are characterized by the amino acid sequence of their hypervariable regions. Initially produced in murine form, they may be converted to chimeric or humanized forms, immunoconjugates or antibody fragments (generally described as binding molecules). The products are useful for the prophylaxis or treatment of transplant rejection, paticularly in combination with other antibodies to activated T-cells, for example CD7 antibodies.

Abstract: Use of a CD25 binding molecule which comprises at least one antigen binding site comprising at least one domain which comprises in sequence, the hypervariable regions CDR1, CDR2 and CDR3; said CDR1 having the amino acid sequence Arg-Tyr-Trp-Met-His, said CDR2 having the amino acid sequence Ala-Ile-Tyr-Pro-Gly-Asn-Ser-Asp-Thr-Ser-Tyr-Asn-Gln-Lys-Phe-Glu-Gly, and said CDR3 having the amino acid sequence Asp-Tyr-Gly-Tyr-Tyr-Phe-Asp-Phe, in the treatment of rheumatoid arthritis or inflammatory or hyperproliferative skin diseases.

Abstract: An optical fiber bend sensor (10) measures the degree and orientation of bending present in a sensor length (30) portion of a fiber assembly (26). Within a multicored fiber (30, 32,34), cores (62, 66) are grouped in non-coplanar pairs. An arrangement of optical elements (28, 36, 38) define within each core pair (62, 66) two optical paths (122, 124) which differ along the sensor length (30): one core (62) of a pair (62, 66) is included in the first path (122), and the other core (66) in the second path (124). A general bending of the sensor region (30) will lengthen one core (62, 66) with respect to the other. Interrogation of this length differential by means of interferometry generates interferograms from which the degree of bending in the plane of the core pair is extracted. Bend orientation can be deduced from data extracted from multiple core pairs.

Abstract: An optical fiber bend sensor (10) measures the degree and orientation of bending present in a sensor length (30) portion of a fiber assembly (26). Within a multicored fiber (30, 32, 34), cores (62, 66) are grouped in non-coplanar pairs. An arrangement of optical elements (28, 36, 38) define within each core pair (62, 66) two optical paths (122, 124) which differ along the sensor length (30): one core (62) of a pair (62, 66) is included in the first path (122), and the other core (66) in the second path (124). A general bending of the sensor region (30) will lengthen one core (62, 66) with respect to the other. Interrogation of this length differential by means of interferometry generates interferograms from which the degree of bending in the plane of the core pair is extracted. Bend orientation can be deduced from data extracted from multiple core pairs.

Abstract: Novel monoclonal antibodies to the CD25 antigen are characterized by the amino acid sequence of their hypervariable regions. Initially produced in murine form, they may be converted to chimeric or humanized forms, immunoconjugates or antibody fragments (generally described as binding molecules). The products are useful for the prophylaxis or treatment of transplant rejection, paticularly in combination with other antibodies to activated T-cells, for example CD7 antibodies.

Abstract: An optical fiber for transmitting radiation comprising two or more core regions, two or more core regions, each core region comprising a substantially transparent core material and having a core refractive index, a core length, and a core diameter, wherein said core regions are arranged within a cladding region, said cladding region comprising a length of first substantially transparent cladding material, having a first refractive index, wherein said first substantially transparent cladding material has an array of lengths of a second cladding material embedded along its length, wherein the second cladding material has a second refractive index which is less than said first refractive index, such that radiation input to said fiber propagates along at least one of said core regions. The cladding region and the core regions may be arranged such that radiation input to said optical fiber propagates along one or more said lengths of said core regions in a single mode of propagation.

Abstract: A sensor system (10) incorporating an interferometer operates as an optical strain gauge. The system (10) is arranged to generate interferograms characterised by an optical path difference between light traversing a sensor arm (12) of the interferometer and light traversing a reference arm (58). Each arm incorporates a highly birefringent optical fibre (38, 58) capable of supporting light propagation at two velocities in two different polarisation modes. A first interferogram is generated between light coupled into the fast eigenmodes of each fibre and a second is generated between light coupled into the slow eigenmodes. Mean optical group delay (.tau..sub.MGD) and differential optical group delay (.tau..sub.DGD) of these interferograms are affected differently by temperature and strain and thus provide a means of discriminating between these attributes of the sensor environment. Thus simultaneous measurement of strain and temperature is achieved.

Abstract: A superior enteric formulation of the antidepressant drug, fluoxetine, is in the form of enteric pellets of which the enteric layer comprises hydroxypropylmethylcellulose acetate succinate.