Abstract: A device and a method for assembling this device for administering a fluid substance are provided. The device includes a housing and a product container, which is accommodated in an axially fixed manner in the housing and has a needle, where the substance can be administered through the needle. The device includes an inwardly directed shoulder support, which is provided on the housing and on which the product container bears with a distally arranged shoulder, in order to prevent an axial relative movement between the product container and the housing in the distal direction.

Abstract: An injection device includes a pre-assembled drive unit connected to a pre-assembled syringe unit. The pre-assembled syringe unit includes a syringe holder and a needle cover and the pre-assembled drive unit includes a plunger rod, a spring member adapted bias the plunger rod in a dispensing direction, a supporting member, and a first and a second retaining element, where each retaining element is configured to be arranged in a holding position in which the first or second retaining element holds the biased plunger rod in place relative to the supporting member and in a release position in which the first or second retaining element does not hold the biased plunger rod in place.

Abstract: A device for administering or discharging a fluid substance includes a housing and a holding element, which is fixed with respect to the housing and in which an injection spring is received. The holding element can be moved radially outwards or radially deflected between an engagement position, in which the holding element is engaged with the injection spring, and a release position, in which the holding element is disengaged from the injection spring. During an axial movement of a needle guard element from the distal position to the proximal position, the holding element can disengage from the injection spring to administer or discharge the substance from the product container through the needle.

Abstract: An injection device for dispensing a drug from a reservoir through a needle includes a housing defining a longitudinal axis, a drive member movable relative to the housing to dispense the drug, a spring member operatively coupled the drive member to move the drive member in a dispensing direction, and a needle cover movable along the longitudinal axis relative to the housing between a needle covering position and a retracted position defining a needle cover movement along a first distance. Additionally, the spring member is operatively coupled to the needle cover such that the needle cover movement causes the spring member to compress or expand.

Abstract: A holder for an inhaler article that includes a sleeve positioned within a housing cavity, a piercing element, and a lockout mechanism. The sleeve comprises a sleeve cavity arranged to receive the inhaler article. The sleeve is movable within the housing cavity between a first and second position. The piercing element is arranged to pierce the inhaler article received within the sleeve when the sleeve is moved from the first position to the second position. The lockout mechanism comprises a guide, a follower member coupled to the sleeve, and a retaining section. The follower member is arranged to move along the guide into the retaining section as the sleeve moves from the second position and back to the first position. The retaining section is arranged to hold the follower member when the sleeve has returned back to the first position, thus retaining the sleeve in the first position.

Abstract: A holder for an inhaler article. The holder comprises a housing comprising a housing cavity. The holder further comprises an engagement member located at least partially within the housing cavity. The engagement member is movable relative to the housing between an upstream position and a downstream position. The engagement member comprised a first follower member. The housing comprises a first guide and a first latch, the first follower member is arranged to follow the first guide between a first position, a second position, and a third position. The first latch is arranged such that the first follower member may pass from the first position to the second position, but may not return to the first position without first passing the third position. An inhaler system comprises a holder and an inhaler article.

Abstract: A holder for an inhaler article that includes a sleeve positioned within a housing cavity, a piercing element, and a lockout mechanism. The sleeve comprises a sleeve cavity arranged to receive the inhaler article. The sleeve is movable within the housing cavity between a first and second position. The piercing element is arranged to pierce the inhaler article received within the sleeve when the sleeve is moved from the first position to the second position. The lockout mechanism comprises a guide, a follower member coupled to the sleeve, and a retaining section. The follower member is arranged to move along the guide into the retaining section as the sleeve moves from the second position and back to the first position. The retaining section is arranged to hold the follower member when the sleeve has returned back to the first position, thus retaining the sleeve in the first position.

Abstract: The invention relates to the ovine embryo cell line HVO-156 (DSM ACC2440), or to cell lines derived therefrom, and to their use for preparing and propagating ovine adenoviruses, in particular recombinant ovine adenoviruses which are derived from the isolate OAV 287.

Abstract: The invention relates to a nonhuman helper-dependent virus vector for transferring nucleic acid sequences. Areas of application are medicine, veterinary medicine, biotechnology and genetic engineering.

Abstract: The invention concerns an adenovirus vector for liver specific gene thera fields of application in medicine are the treatment of gene defects and tumour diseases of the liver and molecular biology. The vector according to the invention is marked by the fact that a therapeutic gene is coupled with a liver-specific promoter consisting of enhancer elements of the hepatitis B virus and an enhancerless minimum promoter and is optionally surrounded by SAR elements wherein the promoter is inserted into the adenovirus genome.