Patents by Inventor Peter M. Blumberg
Peter M. Blumberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190218156Abstract: The present invention relates to novel compositions comprising an agonist and an antagonist, in certain ratios which allow for the onset of agonist action followed quickly by alleviation by antagonist action, and methods of use in personal defense and law enforcement.Type: ApplicationFiled: March 20, 2019Publication date: July 18, 2019Inventors: Peter M. Blumberg, Larry V. Pearce
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Publication number: 20160251276Abstract: The present invention relates to novel compositions comprising an agonist and an antagonist, in certain ratios which allow for the onset of agonist action followed quickly by alleviation by antagonist action, and methods of use in personal defense and law enforcement.Type: ApplicationFiled: January 29, 2016Publication date: September 1, 2016Inventors: Peter M. Blumberg, Larry V. Pearce
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Patent number: 9277748Abstract: The present invention relates to novel compositions comprising an agonist and an antagonist, in certain ratios which allow for the onset of agonist action followed quickly by alleviation by antagonist action, and methods of use in personal defense and law enforcement.Type: GrantFiled: March 11, 2011Date of Patent: March 8, 2016Assignee: The United States of America, as represented by the Secretary, Department of Health & Human ServicesInventors: Peter M. Blumberg, Larry V. Pearce
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Publication number: 20130203736Abstract: The present invention relates to novel compositions comprising an agonist and an antagonist, in certain ratios which allow for the onset of agonist action followed quickly by alleviation by antagonist action, and methods of use in personal defense and law enforcement.Type: ApplicationFiled: March 11, 2011Publication date: August 8, 2013Applicant: USDHHS Office of Technology TransferInventors: Peter M. Blumberg, Larry V. Pearce
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Patent number: 6060505Abstract: Disclosed are modified bryostatins and their use as anticancer drugs.Type: GrantFiled: February 16, 1999Date of Patent: May 9, 2000Assignees: The United States of America as represented by the Department of Health and Human Services, Arizona Board of Regents of Arizona State UniversityInventors: Peter M. Blumberg, Zoltan Szallasi, George R. Pettit
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Patent number: 5879696Abstract: The present invention is directed to preparations of birdseed treated with capsaicin or capsaicin derivatives or analogues thereof in an amount sufficient to be unpalatable to animals having capsaicin sensitive receptors, and more specifically to mammals such as rodents. These "hot" compounds, extracts or whole plant material containing these compounds may be coated on, impregnated in or combined (e.g., mixed) with birdseed to repel troublesome mammals which recognize these compounds as "hot". These "hot" compounds, in contrast, will not repel birds because birds do not recognize these compounds as "hot" since they do not have capsaicin sensitive receptors. The invention is further directed to a method of selectively repelling animals having capsaicin sensitive receptors, which comprises feeding the treated birdseed of the invention to birds, in an amount effective for repelling animals having capsaicin sensitive receptors, thereby discouraging said animals from eating the treated birdseed.Type: GrantFiled: June 12, 1997Date of Patent: March 9, 1999Assignee: The United States of America as represented by the Department of Health and Human ServicesInventor: Peter M. Blumberg
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Patent number: 5874464Abstract: Conformationally constrained diacylglycerol analogues, pharmaceutical compositions comprising such analogues, and methods of using such analogues as agonists and antagonists of protein kinase C.Type: GrantFiled: January 13, 1995Date of Patent: February 23, 1999Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Victor E. Marquez, Jeewoo Lee, Rajiv Sharma, Shaomeng Wang, George W. A. Milne, Marc C. Nicklaus, Peter M. Blumberg, Nancy E. Lewin
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Patent number: 5821269Abstract: The present invention is directed to preparations of birdseed treated with capsaicin or capsaicin derivatives or analogs thereof in an amount sufficient to be unpalatable to animals having capsaicin sensitive receptors, and more specifically to mammals such as rodents. These "hot" compounds, extracts or whole plant material containing these compounds may be coated on, impregnated in or combined (e.g., mixed) with birdseed to repel troublesome mammals which recognize these compounds as "hot". These "hot" compounds, in contrast, will not repel birds because birds do not recognize these compounds as "hot" since they do not have capsaicin sensitive receptors. The invention is further directed to a method of selectively repelling animals having capsaicin sensitive receptors, which comprises feeding the treated birdseed of the invention to birds, in an amount effective for repelling animals having capsaicin sensitive receptors, thereby discouraging said animals from eating the treated birdseed.Type: GrantFiled: June 3, 1992Date of Patent: October 13, 1998Assignee: The United States of America as represented by the Department of Health and Human ServicesInventor: Peter M. Blumberg
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Patent number: 5674902Abstract: The present invention relates to a method of inhibiting a protein kinase C-mediated biological response, such as, hyperplasia. The method comprises administering to a mammal a non-tumor promoting 12-deoxyphorbol ester. Phorbol esters suitable for use in the method include 12-deoxyphorbol 13-monoesters wherein the ester is a formate, acetate, propionate, butyrate, pentanoate, hexanoate, benzoate or phenylacetate ester.Type: GrantFiled: May 26, 1995Date of Patent: October 7, 1997Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Peter M. Blumberg, Zoltan Szallasi
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Patent number: 5672354Abstract: The present invention is directed to preparations of birdseed treated with capsaicin or capsaicin derivatives or analogues thereof in an amount sufficient to be unpalatable to animals having capsaicin sensitive receptors, and more specifically to mammals such as rodents. These "hot" compounds, extracts or whole plant material containing these compounds may be coated on, impregnated in or combined (e.g., mixed) with birdseed to repel troublesome mammals which recognize these compounds as "hot". These "hot" compounds, in contrast, will not repel birds because birds do not recognize these compounds as "hot" since they do not have capsaicin sensitive receptors. The invention is further directed to a method of selectively repelling animals having capsaicin sensitive receptors, which comprises feeding the treated birdseed of the invention to birds, in an amount effective for repelling animals having capsaicin sensitive receptors, thereby discouraging said animals from eating the treated birdseed.Type: GrantFiled: February 5, 1996Date of Patent: September 30, 1997Assignee: The United States of America as represented by the Secretary of the Department of Health & Human ServicesInventor: Peter M. Blumberg
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Patent number: 5599839Abstract: The present invention relates to an antiviral composition and to methods of treating patients with viral infections. The antiviral composition of the present invention comprises prostratin, a phorbol ester derivative, and a pharmaceutically acceptable carrier. The present composition while having antiviral activity does not have substantial tumor promoting activity and does not have other substantial adverse toxicological properties that would preclude its use in antiviral therapy.Type: GrantFiled: April 17, 1995Date of Patent: February 4, 1997Assignees: The United States of America as represented by the Department of Health and Human Services, Brigham Young UniversityInventors: Michael R. Boyd, Paul A. Cox, Gordon M. Cragg, Peter M. Blumberg, Nancy A. Sharkey, Junichi Ishitoya, James B. McMahon, John A. Beutler, Owen S. Weislow, John H. Cardellina, II, Krik R. Gustafson
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Patent number: 5420162Abstract: The present invention relates to a method of inhibiting the protein kinase C-mediated biological response inflammation. The method comprises administering to a mammal a non-tumor promoting 12-deoxyphorbol ester. Phorbol esters suitable for use in the method include 12-deoxyphorbol 13-monoesters wherein the ester is a formate, acetate, propionate, butyrate, pentanoate, hexanote, benzoate or phenylacetate ester. The invention also relates to novel 12-deoxyphorbol 13-monoesters, wherein the ester can be a formate, propionate, butyrate or pentanoate ester, and to pharmaceutical compositions comprising same.Type: GrantFiled: July 31, 1992Date of Patent: May 30, 1995Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Peter M. Blumberg, Zoltan Szallasi
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Patent number: 5405875Abstract: The present invention provides a method of inhibiting neoplasia and tumor promotion. The method comprises administering to a mammal, particularly a human, in need thereof an effective amount of a 12-deoxyphorbol ester, particularly a 12-deoxyphorbol 13-monoester such as 12-deoxyphorbol 13-acetate (prostratin) and 12-deoxyphorbol 13-phenylacetate (dPP).Type: GrantFiled: May 20, 1993Date of Patent: April 11, 1995Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Peter M. Blumberg, Zoltan Szallasi
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Patent number: 5290816Abstract: The present invention relates to a method for desensitizing a subject animal, which comprises administering to the subject animal a therapeutically effective desensitizing amount of resiniferatoxin for desensitizing the subject animal to neurogenic inflammation, to chemically and thermally induced pain and to responses involving sensory afferent pathways sensitive to capsaicin and to responses involving the hypothalamic temperature control region, and a pharmaceutically acceptable carrier therefor.Type: GrantFiled: June 21, 1990Date of Patent: March 1, 1994Assignee: The United States of America as represented by the Secretary of Health and Human ServicesInventor: Peter M. Blumberg
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Patent number: 5232684Abstract: The present invention relates to labelled resiniferatoxin and congeners thereof. Preferably, the labelled compounds of the invention are radio or fluorescently labelled. The invention is further directed to compositions comprising these labelled compounds, as well as to methods of using these compounds.Type: GrantFiled: June 29, 1990Date of Patent: August 3, 1993Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Peter M. Blumberg, Arpad Szallasi, Zoltan Szallasi
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Patent number: 5021450Abstract: The present invention relates to a new class of compounds having a variable spectrum of activities for capsaicin-like responses, compositions thereof, processes for preparing the same, and uses thereof. Compounds of the invention are prepared by combining phorbol related diterpenses and homovanillac acid analogs via esterification at the exocyclic hydroxy group of the diterpene. Examples of these compounds include 20-homovanillyl-mezerein and 20-homovanillyl-12-deoxyphorbol-13-phenylacetate.Type: GrantFiled: May 30, 1989Date of Patent: June 4, 1991Assignee: The United States of America as represented by the Secretary of the Department of Health and Human ServicesInventor: Peter M. Blumberg
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Patent number: 4939149Abstract: The present invention relates to a method for desensitizing a subject animal, which comprises administering to the subject animal a therapeutically effective desensitizing amount of resiniferatoxin for desensitizing the subject animal to neurogenic inflammation, to chemically and thermally induced pain and to responses involving sensory afferent pathways sensitive to capsaicin and to responses involving the hypothalamic temperature control region, and a pharmaceutically acceptable carrier therefor.Type: GrantFiled: October 24, 1988Date of Patent: July 3, 1990Assignee: The United States of America as represented by the Department of Health and Human ServicesInventor: Peter M. Blumberg