Patents by Inventor Peter M. Fischer
Peter M. Fischer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11957527Abstract: Packaging systems are configured for improving long-term stability of a composition. Packaging systems may include a packaging container defining an enclosed volume. The packaging system may additionally include a removable cover that enables the packaging container to be opened and closed such that the packaging container system includes a sealed or sealable volume to contain a main composition in fluid communication with a sacrificial composition. The main composition may include one or more volatile or gas-releasing materials and the sacrificial material may include a stabilizing component that replaces the at least one volatile or gas-releasing component within the main composition or displaces the at least one volatile or gas-releasing component within the enclosed volume. The sacrificial composition helps maintain stability of the main composition by accelerating equilibrium of vapors or gases within the headspace of the sealed interior volume.Type: GrantFiled: December 22, 2020Date of Patent: April 16, 2024Assignee: ULTRADENT PRODUCTS, INC.Inventors: Peter M. Allred, Dan E. Fischer
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Patent number: 11931220Abstract: Wax-based compositions for making barrier layers used in oral treatment devices are thermally stable when formed into a flat sheet or three-dimensional article to a temperature of at least 45° C. and are plastically deformable at room temperature (25° C.). The wax-based compositions include a wax fraction homogeneously blended with a polymer fraction. The wax fraction includes at least one wax and the polymer fraction includes at least one polymer selected such that, when the at least one wax and at least one polymer are homogeneously blended together, they yield a wax-based composition having the desired properties of thermal stability and plastic deformability. Barrier layers and oral treatment devices made from such wax-based compositions are dimensionally stable to a temperature of at least 40° C. without external support and can be plastically deformed in a user's mouth to become at least partially customized to the size and shape of user's unique dentition.Type: GrantFiled: April 9, 2020Date of Patent: March 19, 2024Assignee: ULTRADENT PRODUCTS, INC.Inventors: Steven B. Johnson, David Lawrence Margetts, Barry Lee Hobson, Jonathan D. Scoville, Neil T. Jessop, Peter M. Allred, Dan E. Fischer
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Publication number: 20140094493Abstract: A compound of Formula (I), and its pharmaceutically acceptable salt or salts and physiologically hydrolysable derivatives in free form or salt form: wherein R1 is independently selected from F, Cl, Br, CN, NH2, OH, CHO, COOH, oxo, C1-4alkyl, C1-4alkoxy, CONH2 (optionally mono- or di-substituted by C1-4alkyl) and SO2NH2, R2 is independently selected from C1-6allkyl substituted by R3 wherein the C1-6alkyl chain optionally comprises one or two heteroatoms select from O; R3 is selected from aryl, C3-6cycloalkyl, C3-6heterocyclyl and C3-6heteroaryl, wherein the heterocyclyl and heteroaryl rings are nitrogen containing; and wherein R3 is optonally substituted by one or more groups selected from R1; n1 is zero or an integer from 1 to 2; n2 is an integer from 1 to 2; and the sum of n1 and 2 is less than or equal to 2; R5 is selected from any group defined for R1 and R2; R6a and R6b are independently selected from H or C1-4alkyl; R7 is independently selected from F, Cl, Br, CN, NH2, OH, CHO, COOH, oxo, C1-4alType: ApplicationFiled: February 6, 2012Publication date: April 3, 2014Inventors: Jillian G. Baker, Peter M. Fischer, Christophe Fromont, Sheila M. Gardiner, Stephen J. Hill, Gopal Jadhav, Barrie Kellam, Shailesh Mistry, Jeanette Woolard
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Patent number: 7153931Abstract: The invention relates to modified and truncated forms of the membrane transport vector penetratin. Such truncated forms include 7-mer peptides that may in themselves include further variation.Type: GrantFiled: November 12, 1999Date of Patent: December 26, 2006Assignee: Cyclacel LimitedInventors: Peter M. Fischer, Nikolai Zhelev, Shudong Wang
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Patent number: 6992169Abstract: The present invention relates to a novel drug delivery system of use in the improved delivery of drug therapeutic agents into target cells. The system comprises a drug moiety linked to a carrier moiety wherein the carrier moiety comprises a homeobox peptide or a fragment or derivative thereof.Type: GrantFiled: July 31, 2002Date of Patent: January 31, 2006Assignee: Cyclacel LimitedInventors: Peter M. Fischer, Shudong Wang, Nikolai Zhelev
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Publication number: 20040176301Abstract: The present invention relates to p21 derived peptides capable of inhibiting CDK/cyclin complexes, particularly cyclins A or E/CDK2, by modifying the interaction with their substrates. The peptides are derived from a C-terminal region of p21 and display selectivity for cyclin/CDK2 inhibition over cyclin/CDK4 inhibition. Variants of such peptides particularly involving certain alanine replacements are shown to be particularly potent.Type: ApplicationFiled: May 19, 2003Publication date: September 9, 2004Applicant: Cyclacel LimitedInventors: Daniella I. Zheleva, Peter M. Fischer, Campbell McInnes, Martin J.I. Andrews, Weng C. Chan, Gail E. Atkinson
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Patent number: 6699854Abstract: The present invention relates to 2-substituted 4-heteroaryl-pyrimidines, their preparation, pharmaceutical compositions containing them and their use as inhibitors of cyclin-dependent kinases (CDKs) and hence their use in the treatment of proliferative disorders such as cancer, leukaemia, psoriasis and the like.Type: GrantFiled: December 20, 2002Date of Patent: March 2, 2004Assignee: Cyclacel LimitedInventors: Shudong Wang, Peter M. Fischer
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Publication number: 20030149057Abstract: The present invention relates to 2-substituted 4-heteroaryl-pyrimidines, their preparation, pharmaceutical compositions containing them and their use as inhibitors of cyclin-dependent kinases (CDKs) and hence their use in the treatment of proliferative disorders such as cancer, leukaemia, psoriasis and the like.Type: ApplicationFiled: December 20, 2002Publication date: August 7, 2003Applicant: Cyclacel LimitedInventors: Shudong Wang, Peter M. Fischer
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Publication number: 20030119735Abstract: The present invention relates to a novel drug delivery system of use in the improved delivery of drug therapeutic agents into target cells. The system comprises a drug moiety linked to a carrier moiety wherein the carrier moiety comprises a homeobox peptide or a fragment or derivative thereof.Type: ApplicationFiled: July 31, 2002Publication date: June 26, 2003Applicant: Cyclacel Limited of United KingdomInventors: Peter M. Fischer, Shudong Wang, Nikolai Zhelev
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Patent number: 6531479Abstract: The present invention relates to 2-substituted 4-heteroaryl-pyrimidines, their preparation, pharmaceutical compositions containing them and their use as inhibitors of cyclin-dependent kinases (CDKs) and hence their use in the treatment of proliferative disorders such as cancer, leukaemia, psoriasis and the like.Type: GrantFiled: March 29, 2001Date of Patent: March 11, 2003Assignee: Cyclacel LimitedInventors: Shudong Wang, Peter M. Fischer
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Publication number: 20030036628Abstract: The present invention relates to p21 derived peptides capable of inhibiting CDK/cyclin complexes, particularly cyclins A or E/CDK2, by modifying the interaction with their substrates. The peptides are derived from a C-terminal region of p21 and display selectivity for cyclin/CDK2 inhibition over cyclin/CDK4 inhibition. Variants of such peptides particularly involving certain alanine replacements are shown to be particularly potent.Type: ApplicationFiled: November 29, 2000Publication date: February 20, 2003Inventors: Daniella I. Zheleva, Peter M. Fischer, Campbell McInnes, Martin J.I. Andrews, Weng C. Chan, Gail E. Atkinson
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Patent number: 6472507Abstract: The present invention relates to a novel drug delivery system of use in the improved delivery of drug therapeutic agents into target cells. The system comprises a drug moiety linked to a carrier moiety wherein the carrier moiety comprises a homeobox peptide or a fragment or derivative thereof.Type: GrantFiled: July 2, 1999Date of Patent: October 29, 2002Assignee: Cyclacel LimitedInventors: Peter M. Fischer, Shudong Wang, Nikolai Zhelev
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Publication number: 20020019404Abstract: The present invention relates to 2-substituted 4-heteroaryl-pyrimidines, their preparation, pharmaceutical compositions containing them and their use as inhibitors of cyclin-dependent kinases (CDKs) and hence their use in the treatment of proliferative disorders such as cancer, leukaemia, psoriasis and the like.Type: ApplicationFiled: March 29, 2001Publication date: February 14, 2002Inventors: Shudong Wang, Peter M. Fischer