Patents by Inventor Peter M.J. Quinn

Peter M.J. Quinn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • VECTORS AND COMPOSITIONS FOR GENE AUGMENTATION OF CRUMBS COMPLEX HOMOLOGUE 1 (CRB1) MUTATIONS
    Publication number: 20250108133
    Abstract: The present disclosure provides compositions and vectors comprising a transgene(s) encoding more than one isoform of Crumbs homologue-1 (CRB1) (e.g., CRB1-A and CRB1-B), and compositions thereof, for use in the treatment or prevention of CRB1-related diseases and disorder (e.g., autosomal recessive retinitis pigmentosa (RP) and Leber congenital amaurosis (LCA)).
    Type: Application
    Filed: December 13, 2024
    Publication date: April 3, 2025
    Inventors: Peter M.J. Quinn, Stephen H. Tsang, Yi-Ting Tsai
  • METHODS AND SYSTEMS FOR CORRECTING MUTATIONS IN PRPH2
    Publication number: 20250090690
    Abstract: The present disclosure provides systems, methods, and compositions for prime-editing modification of c.828 splice site mutations in the peripherin-2 gene. Particularly the present disclosure provides systems, methods, and compositions for correcting one or more disease-causing splice site mutations selected from: c.828+3A>T, c.828+1G>A, c.828+2T>C, c.828+1G>T, and combinations thereof.
    Type: Application
    Filed: November 13, 2024
    Publication date: March 20, 2025
    Inventors: Yi-Ting Tsai, Salvatore M. Caruso, Bruna Lopes da Costa, Stephen H. Tsang, Peter M.J. Quinn
  • METHODS AND SYSTEMS FOR MODIFYING THE CRUMBS HOMOLOGUE-1 (CRB1) GENE
    Publication number: 20240344055
    Abstract: The present disclosure provides systems, methods, and compositions for modifying the crumbs homologue-1 gene. Particularly the present disclosure provides systems, methods, and compositions for prime editing insertion or correction of mutations in the crumbs homologue-1 gene.
    Type: Application
    Filed: March 27, 2024
    Publication date: October 17, 2024
    Inventors: Peter M.J. Quinn, Bruna Lopes da Costa, Stephen H. Tsang, David R. Liu
  • DUAL EXPRESSION VECTOR FOR GENE AUGMENTATION FOR CRUMBS COMPLEX HOMOLOGUE 1 (CRB1) MUTATIONS
    Publication number: 20230392164
    Abstract: The present disclosure provides vectors comprising a transgene(s) encoding more than one isoform of Crumbs homologue-1 (CRB1) (e.g., CRB1-A and CRB1-B), and compositions thereof, for use in the treatment or prevention of CRB1-related diseases and disorder (e.g., autosomal recessive retinitis pigmentosa (RP) and Leber congenital amaurosis (LCA)).
    Type: Application
    Filed: March 3, 2023
    Publication date: December 7, 2023
    Inventors: Peter M.J. Quinn, Stephen H. Tsang, Yi-Ting Tsai
  • DUAL EXPRESSION VECTOR FOR GENE AUGMENTATION FOR CRUMBS COMPLEX HOMOLOGUE 1 (CRB1) MUTATIONS
    Publication number: 20220186253
    Abstract: The present disclosure provides vectors comprising a transgene(s) encoding more than one isoform of Crumbs homologue-1 (CRB1) (e.g., CRB1-A and CRB1-B), and compositions thereof, for use in the treatment or prevention of CRB1-related diseases and disorder (e.g., autosomal recessive retinitis pigmentosa (RP) and Leber congenital amaurosis (LCA)).
    Type: Application
    Filed: December 17, 2021
    Publication date: June 16, 2022
    Inventors: Peter M.J. Quinn, Stephen H. Tsang, Yi-Ting Tsai