Patents by Inventor Peter M. Levine
Peter M. Levine has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12038406Abstract: The described embodiments may provide a chemical detection circuit that may comprise a plurality of first output circuits at a first side and a plurality of second output circuits at a second side of the chemical detection circuit. The chemical detection circuit may further comprise a plurality of tiles of pixels each placed between respective pairs of first and second output circuits. Each tile may include four quadrants of pixels. Each quadrant may have columns with designated first columns interleaved with second columns. Each first column may be coupled to a respective first output circuit in first and second quadrants, and to a respective second output circuit in third and fourth quadrants. Each second column may be coupled to a respective second output circuit in first and second quadrants, and to a respective first output circuit in third and fourth quadrants.Type: GrantFiled: October 7, 2020Date of Patent: July 16, 2024Assignee: Life Technologies CorporationInventors: Kim L. Johnson, Jeremy Jordan, Peter M Levine, Mark James Milgrew
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Publication number: 20240201127Abstract: The described semiconductor device can include a two-transistor pixel array. Each pixel in the two-transistor pixel array can include a chemical detection pixel comprising a chemically-sensitive transistor and a row-selection transistor connected between a current source and a chemically-sensitive transistor. The source of the chemically-sensitive transistor can be coupled to a column line, and the drain of the chemically-sensitive transistor can be coupled to the source of the row selection transistor. The gate of the row selection transistor can be couple to a row line. When a row line is activated, the row selection transistor can couple the chemically-sensitive transistor to the column line.Type: ApplicationFiled: December 5, 2023Publication date: June 20, 2024Inventors: Kim L. JOHNSON, Jeremy JORDAN, Mark J. MILGREW, Peter M. LEVINE
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Publication number: 20210172907Abstract: The described embodiments may provide a chemical detection circuit that may comprise a plurality of first output circuits at a first side and a plurality of second output circuits at a second side of the chemical detection circuit. The chemical detection circuit may further comprise a plurality of tiles of pixels each placed between respective pairs of first and second output circuits. Each tile may include four quadrants of pixels. Each quadrant may have columns with designated first columns interleaved with second columns. Each first column may be coupled to a respective first output circuit in first and second quadrants, and to a respective second output circuit in third and fourth quadrants. Each second column may be coupled to a respective second output circuit in first and second quadrants, and to a respective first output circuit in third and fourth quadrants.Type: ApplicationFiled: October 7, 2020Publication date: June 10, 2021Applicant: Life Technologies CorporationInventors: Kim L. JOHNSON, Jeremy JORDAN, Peter M LEVINE, Mark James MILGREW
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Patent number: 10718732Abstract: Electrochemical sensing of biomolecules eliminates the need for bulky optical instruments required in traditional fluorescence-based sensing assays. Integration of the sensor interface electrodes and active electrochemical detection circuitry on CMOS substrates miniaturizes the sensing platform, enhancing portability for point-of-care applications, while enabling high-throughput, highly-parallel analysis. One embodiment includes a four-by-four active sensor array for multiplexed electrochemical biomolecular detection in a standard 0.25-?m CMOS process. Integrated potentiostats, including control amplifiers and dual-slope ADCs, stimulate the electrochemical cell and detect the current flowing through on-chip gold electrodes at each sensor site resulting from biomolecular reactions occurring on the chip surface. Post-processing techniques for fabricating biologically-compatible surface-electrode arrays in CMOS that can withstand operation in harsh electrochemical environments are described.Type: GrantFiled: August 19, 2016Date of Patent: July 21, 2020Assignee: The Trustees Of Columbia University In The City of New YorkInventors: Peter M. Levine, Kenneth L. Shepard, Ping Gong, Levicky Rastislav
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Publication number: 20180224393Abstract: The described embodiments may provide a chemical detection circuit that may comprise a plurality of first output circuits at a first side and a plurality of second output circuits at a second side of the chemical detection circuit. The chemical detection circuit may further comprise a plurality of tiles of pixels each placed between respective pairs of first and second output circuits. Each tile may include four quadrants of pixels. Each quadrant may have columns with designated first columns interleaved with second columns. Each first column may be coupled to a respective first output circuit in first and second quadrants, and to a respective second output circuit in third and fourth quadrants. Each second column may be coupled to a respective second output circuit in first and second quadrants, and to a respective first output circuit in third and fourth quadrants.Type: ApplicationFiled: April 2, 2018Publication date: August 9, 2018Inventors: Kim L. JOHNSON, Jeremy JORDAN, Peter M. LEVINE, Mark James MILGREW
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Publication number: 20170146479Abstract: Electrochemical sensing of biomolecules eliminates the need for bulky optical instruments required in traditional fluorescence-based sensing assays. Integration of the sensor interface electrodes and active electrochemical detection circuitry on CMOS substrates miniaturizes the sensing platform, enhancing portability for point-of-care applications, while enabling high-throughput, highly-parallel analysis. One embodiment includes a four-by-four active sensor array for multiplexed electrochemical biomolecular detection in a standard 0.25-?m CMOS process. Integrated potentiostats, including control amplifiers and dual-slope ADCs, stimulate the electrochemical cell and detect the current flowing through on-chip gold electrodes at each sensor site resulting from biomolecular reactions occurring on the chip surface. Post-processing techniques for fabricating biologically-compatible surface-electrode arrays in CMOS that can withstand operation in harsh electrochemical environments are described.Type: ApplicationFiled: August 19, 2016Publication date: May 25, 2017Applicant: The Trustees Of Columbia University In The City Of New YorkInventors: Peter M. Levine, Kenneth L. Shepard, Ping Gong, Levicky Rastislav
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Publication number: 20150241387Abstract: The described embodiments may provide a chemical detection circuit that may comprise a plurality of first output circuits at a first side and a plurality of second output circuits at a second side of the chemical detection circuit. The chemical detection circuit may further comprise a plurality of tiles of pixels each placed between respective pairs of first and second output circuits. Each tile may include four quadrants of pixels. Each quadrant may have columns with designated first columns interleaved with second columns. Each first column may be coupled to a respective first output circuit in first and second quadrants, and to a respective second output circuit in third and fourth quadrants. Each second column may be coupled to a respective second output circuit in first and second quadrants, and to a respective first output circuit in third and fourth quadrants.Type: ApplicationFiled: January 15, 2015Publication date: August 27, 2015Inventors: Kim L. JOHNSON, Jeremy JORDAN, Peter M. LEVINE, Mark James MILGREW
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Patent number: 8983783Abstract: The described embodiments may provide a chemical detection circuit that may comprise a plurality of first output circuits at a first side and a plurality of second output circuits at a second side of the chemical detection circuit. The chemical detection circuit may further comprise a plurality of tiles of pixels each placed between respective pairs of first and second output circuits. Each tile may include four quadrants of pixels. Each quadrant may have columns with designated first columns interleaved with second columns. Each first column may be coupled to a respective first output circuit in first and second quadrants, and to a respective second output circuit in third and fourth quadrants. Each second column may be coupled to a respective second output circuit in first and second quadrants, and to a respective first output circuit in third and fourth quadrants.Type: GrantFiled: April 11, 2013Date of Patent: March 17, 2015Assignee: Life Technologies CorporationInventors: Kim L. Johnson, Jeremy Jordan, Peter M. Levine, Mark James Milgrew
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Publication number: 20140361781Abstract: One or more charge pumps may be used to amplify the output voltage from a chemically-sensitive pixel that comprises one or more transistors. A charge pump may include a number of track stage switches, a number of boost phase switches and a number of capacitors. The capacitors are in parallel during the track phase and in series during the boost phase, and the total capacitance is divided during the boost phase while the total charge remains fixed. Consequently, the output voltage is pushed up.Type: ApplicationFiled: August 21, 2014Publication date: December 11, 2014Inventors: Peter M. LEVINE, Mark James MILGREW, Todd REARICK
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Publication number: 20100300899Abstract: Electrochemical sensing of biomolecules eliminates the need for bulky optical instruments required in traditional fluorescence-based sensing assays. Integration of the sensor interface electrodes and active electrochemical detection circuitry on CMOS substrates miniaturizes the sensing platform, enhancing portability for point-of-care applications, while enabling high-throughput, highly-parallel analysis. One embodiment includes a four-by-four active sensor array for multiplexed electrochemical biomolecular detection in a standard 0.25-?m CMOS process. Integrated potentiostats, including control amplifiers and dual-slope ADCs, stimulate the electrochemical cell and detect the current flowing through on-chip gold electrodes at each sensor site resulting from biomolecular reactions occurring on the chip surface. Post-processing techniques for fabricating biologically-compatible surface-electrode arrays in CMOS that can withstand operation in harsh electrochemical environments are described.Type: ApplicationFiled: June 21, 2010Publication date: December 2, 2010Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Peter M. Levine, Kenneth L. Shepard, Ping Gong, Levicky Rastislav