Patents by Inventor Peter M. Morganelli

Peter M. Morganelli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for detecting inflammation and inflammatory conditions
    Patent number: 7144710
    Abstract: Methods for detecting the inflammatory biomarkers molecule CD 163 in biological samples are provided. Also provided are methods for monitoring the course of an inflammatory process or condition in a patient and compositions and methods for preventing and treating inflammation and inflammatory processes.
    Type: Grant
    Filed: March 27, 2001
    Date of Patent: December 5, 2006
    Assignee: Trustees of Dartmouth College
    Inventors: Paul M. Guyre, Peter M. Morganelli, Nicholas J. Goulding
  • Method for detecting inflammation and inflammatory conditions
    Publication number: 20030215885
    Abstract: Methods for detecting the inflammatory biomarkers molecule CD 163 in biological samples are provided. Also provided are methods for monitoring the course of an inflammatory process or condition in a patient and compositions and methods for preventing and treating inflammation and inflammatory processes.
    Type: Application
    Filed: April 17, 2003
    Publication date: November 20, 2003
    Inventors: Paul M. Guyre, Peter M. Morganelli, Nicholas J. Goulding
  • Methods for detecting inflammation and inflammatory conditions
    Publication number: 20010041177
    Abstract: Methods for detecting the inflammatory biomarker molecule CD163 in biological samples are provided. Also provided are methods for monitoring the course of an inflammatory process or condition in a patient and compositions and methods for preventing and treating inflammation and inflammatory processes.
    Type: Application
    Filed: March 27, 2001
    Publication date: November 15, 2001
    Inventors: Paul M. Guyre, Peter M. Morganelli, Nicholas J. Goulding
  • Bispecific reagents for redirected targeting of human lipoproteins
    Patent number: 6193967
    Abstract: Bispecific molecules which react both with an Fc&ggr; receptor for immunoglobulin G (IgG) of human effector cells and with either human low density lipoprotein (LDL), or fragment thereof, or human high density lipoprotein (HDL), or a fragment thereof, are disclosed. The bispecific molecules bind to an Fc&ggr; receptor without being blocked by the binding of IgG to the same receptor. The bispecific molecules having a binding specificity for human LDL are useful for targeting human effector cells for degradation of LDL in vivo. The bispecific molecules of the present invention which have a binding specificity for human HDL are useful for targeting human HDL to human effector cells such that the HDL takes up cholesterol from the effector cells. Also disclosed are methods of treating atherosclerosis using these bispecific molecules.
    Type: Grant
    Filed: October 8, 1997
    Date of Patent: February 27, 2001
    Inventor: Peter M. Morganelli
  • Bispecific reagents for redirected targeting of human lipoproteins
    Patent number: 5762930
    Abstract: Bispecific molecules which react both with an Fc.gamma. receptor for immunoglobulin G (IgG) of human effector cells and with either human low density lipoprotein (LDL), or fragment thereof, or human high density lipoprotein (HDL), or a fragment thereof, are disclosed. The bispecific molecules bind to an Fc.gamma. receptor without being blocked by the binding of IgG to the same receptor. The bispecific molecules having a binding specificity for human LDL are useful for targeting human effector cells for degradation of LDL in vivo. The bispecific molecules of the present invention which have a binding specificity for human HDL are useful for targeting human HDL to human effector cells such that the HDL takes up cholesterol from the effector cells. Also disclosed are methods of treating atherosclerosis using these bispecific molecules.
    Type: Grant
    Filed: November 19, 1993
    Date of Patent: June 9, 1998
    Inventors: Michael W. Fanger, Peter M. Morganelli
  • Monoclonal antibodies specific for a human mononculear phagocyte-specific antigen
    Patent number: 5077216
    Abstract: A 155 kDa phagocyte-specific antigen which is expressed on human monocytes, monocyte-derived macrophages and peritoneal macrophages, but is not expressed on human granulocytes, lymphocytes and platelets is described.
    Type: Grant
    Filed: July 6, 1988
    Date of Patent: December 31, 1991
    Assignee: The Trustees of Dartmouth College
    Inventors: Peter M. Morganelli, Paul M. Guyre