Abstract: Mammalian cells are described that includes a recombination target site integrated within high integrating locus. Recombinant protein producer cell lines incorporating the mammalian cells and methods for forming the mammalian cells are also described. The high integrating loci have been developed through understanding and mapping of the three dimensional hierarchical structure of chromatin in mammalian cells. The high integrating loci are present in transcriptionally active environments that can provide both chromatin accessibility and epigenetic stability. As such, the recombinant mammalian cells can provide predictable and stable transgene production.

Abstract: The present invention, in general, provides for a testing system and method for detecting defects within a circuit. A current signature of the quiescent current of the circuit is determined, and certain constant values are calculated based on the current signature using a linear iterative regression. A defect free state for the circuit associated with a minimum quiescent current (IDDQ) is then determined. The IDDQ of the circuit for this state is measured, and a signal indicating the IDDQ at this state is used along with the aforementioned constant values to create upper and lower threshold values. Thereafter, signals indicating the value of IDDQ for a plurality of other states are compared to the upper and lower threshold values. The circuit is determined to be defective if the values of any of the signals is greater than the upper threshold value or is less than the lower threshold value.

Abstract: The present invention, in general, provides for a testing system and method for detecting defects within a circuit. A current signature of the quiescent current of the circuit is determined, and certain constant values are calculated based on the current signature using a linear iterative regression. A defect free state for the circuit associated with a minimum quiescent current (IDDQ) is then determined. The IDDQ of the circuit for this state is measured, and a signal indicating the IDDQ at this state is used along with the aforementioned constant values to create upper and lower threshold values. Thereafter, signals indicating the value of IDDQ for a plurality of other states are compared to the upper and lower threshold values. The circuit is determined to be defective if the values of any of the signals is greater than the upper threshold value or is less than the lower threshold value.

Abstract: Disclosed is a method and apparatus for recovering iodine from an aqueous suspension. Particulate iodine is formed on a filter septum and forms a cake of solid iodine. The cake is removed by backwash with a liquid or by blowback with a gas. Contact of the iodine with the environment is minimized.

Abstract: A structured meat product which may resemble a natural cut of meat comprises a lean portion formed by extrusion of multiple lean meat chunks bonded by a protein exudate and a fat cap or rim formed by simultaneous extrusion of a fat emulsion. The product is made by preparing chunks of lean meat substantially free of fat, gristle and sinew. The muscle scaffold network is slackened e.g., by multiple severing of the connective tissue of the lean meat chunks. These chunks then are massaged under reduced pressure to produce the protein exudate, while sufficient water is added to obtain a desired protein-to-moisture ratio. Fat trimmings are ground and blended into an emulsion which is simultaneously extruded with the lean meat chunks through separate but adjacent extrusion heads which may be shaped to produce a product resembling a steak, roast or other conventional cut of natural meat.