Abstract: Multifunctional occlusion crossover devices include features to improve the crossover balloon occlusion technique used during transcatheter aortic valve replacement procedures, for example. The devices include a compliant balloon incorporated with a highly flexible and lubricous sheath system. The balloon is capable of safely occluding from the common iliac artery and down to an access site in the femoral artery. The devices can simplify the CBOT technique and replace multiple devices currently used for the procedure.