Abstract: A body tissue treatment system comprising a heating device and a topical cream comprises controlled, non-burning heat exhibiting greater temperature fluctuation than a conventional heating device. At high temperature settings, the heating elements fluctuate widely between a relatively high maximum and low minimum to produce periods of intense heat input into the skin followed by sufficient cooling to prevent burning of the skin. Such application of intense heat to the skin, for short periods in which temperatures reach their peaks, relaxes musculature surrounding the injured area and significantly improves blood flow, skin permeability, and sweat gland openness in the area, which allows the topical cream to more readily penetrate skin and/or injured body tissues.

Abstract: A composition and method for treating both superficial and subdermal inflammation is taught by treating an inflamed skin area, muscle, or bone joint, with a therapeutically effective amount of a skin-compatible ester of a zwitterionic aminosulphonic acid (ZASA-Ester) of the formula. ROCH2—CH2—N N—CH2CH2 SO3M wherein M is an alkali metal, like sodium, and R is a naturally occurring, straight-chain, saturated or unsaturated, aliphatic acid moiety, selected from one of the groups consisting of alkanes, alkenes, and alkadienes, each having a hydrocarbon chain of from one to twenty carbon atoms. The resulting HEPES esters are represented by the acetic acid ester as an exemplary alkane, the oleic acid ester as a exemplary alkene, and the linoleic acid ester as an exemplary alkadiene, the esters of which form fatty acids in nature. The most useful of which are the acetic oleic (cis isomer), linoleic, palmitic, and stearic moieties; they occur naturally as glycerides, i.e., esters of glycerol.

Abstract: Methods for treating muscular inflammation comprise applying to an inflamed area a therapeutically effective amount of a skin-compatible ester of a zwitterionic aminosulphonic acid of the formula wherein M is an alkali metal and R is a straight chain aliphatic acid moiety. Compositions for treating inflammation comprising a therapeutically effective amount of a skin-compatible component comprising an ester, ether, urethane, amide or urea of at least one compound selected from a specified group. Additional methods for treating inflammation comprise applying to an inflamed area a therapeutically effective amount of a skin-compatible component comprising an ester, ether, urethane, amide or urea of at least one compound selected from a specified group.

Abstract: A composition and method for treating both superficial and subdermal inflammation is taught by treating an inflamed skin area, muscle, or bone joint, with a therapeutically effective amount of a skin-compatible ester of a zwitterionic aminosulphonic acid (ZASA-Ester) of the formula. ##STR1## wherein M is an alkali metal, like sodium, and R is a naturally occurring, straight-chain, saturated or unsaturated, aliphatic acid, the esters of which form fatty acids in nature. The most useful of which are the acetic oleic (cis isomer), linoleic, palmitic, and stearic moieties; they occur naturally as glycerides, i.e., esters of glycerol. Also useful are analogs of HEPES like piperazine-N'-(2-ethane sulfonic acid); N-methylpiperazine-N'-(2-ethane sulfonic acid);, and the piperiodine analog of the piperazine ester.A pharmacologic composition is also provided which comprises at least one amphoteric (Zwitterionic-ester) with a pharmacologically-acceptable topical carrier or base.