Patents by Inventor Peter M. Schlag

Peter M. Schlag has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Niclosamide for the treatment of cancer metastasis
    Patent number: 11331290
    Abstract: A method for inhibiting, reducing and/or reducing the risk of cancer metastasis in a subject, including identifying a subject as in need of inhibiting, reducing and/or reducing the risk of cancer metastasis, by identifying the subject as having a cancer with an elevated or up-regulated level of S100A4 transcription compared to a level in non-oncogenic cells, and administering to the subject a therapeutically effective amount of niclosamide or a niclosamide derivate, thereby inhibiting or reducing S100A4 transcription, so as to inhibit, reduce and/or reduce the risk of cancer metastasis, wherein 15 to 400 mg niclosamide or niclosamide derivate is administered per kg body weight of the subject (mg/kg), 1 or 2 times daily.
    Type: Grant
    Filed: January 28, 2020
    Date of Patent: May 17, 2022
    Assignee: Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
    Inventors: Ulrike Stein, Wolfgang Walther, Ulrike Sack, Peter M. Schlag
  • NICLOSAMIDE FOR THE TREATMENT OF CANCER METASTASIS
    Publication number: 20200155484
    Abstract: A method for inhibiting, reducing and/or reducing the risk of cancer metastasis in a subject, including identifying a subject as in need of inhibiting, reducing and/or reducing the risk of cancer metastasis, by identifying the subject as having a cancer with an elevated or up-regulated level of S100A4 transcription compared to a level in non-oncogenic cells, and administering to the subject a therapeutically effective amount of niclosamide or a niclosamide derivate, thereby inhibiting or reducing S100A4 transcription, so as to inhibit, reduce and/or reduce the risk of cancer metastasis, wherein 15 to 400 mg niclosamide or niclosamide derivate is administered per kg body weight of the subject (mg/kg), 1 or 2 times daily.
    Type: Application
    Filed: January 28, 2020
    Publication date: May 21, 2020
    Inventors: ULRIKE STEIN, WOLFGANG WALTHER, ULRIKE SACK, PETER M. SCHLAG
  • Use of a DNA expression construct
    Patent number: 9375435
    Abstract: The present invention relates to the use of a DNA expression construct comprising a dumbbell-shaped circular strand of deoxyribonucleic acids and provides such a construct with a double-stranded stem and single-stranded loops located at both ends of the stem, wherein the stem comprises complementary deoxyribonucleic acids of the circular strand with a promotor sequence, a coding sequence and a termination signal to be administered by jet injection for the treatment of cancer.
    Type: Grant
    Filed: September 8, 2011
    Date of Patent: June 28, 2016
    Assignees: MOLOGEN AG, MAX-DELBRUCK-CENTRUM FUR MOLEKULARE MEDIZIN (MDC) BERLIN-BUCH
    Inventors: Wolfgang Walther, Peter M. Schlag, Dennis Kobelt, Manuel Schmidt
  • MACC1 AS A PROGNOSTIC BIOMARKER FOR HEPATOBILIARY TUMORS
    Publication number: 20140356868
    Abstract: The present invention is directed to a method of diagnosis and prognostication of a hepatobiliary tumor, the method comprising the step of determining expression of MACC1 polypeptide or of a nucleic acid encoding said MACC1 polypeptide in a biological sample.
    Type: Application
    Filed: May 30, 2014
    Publication date: December 4, 2014
    Inventors: Ulrike STEIN, Peter M. SCHLAG, Andri LEDERER, Daniel SEEHOFER, Pia HERMANN
  • NICLOSAMIDE FOR THE TREATMENT OF CANCER METASTASIS
    Publication number: 20140294957
    Abstract: The invention relates to niclosamide and derivates thereof, which effectively inhibit transcription of the S100A4 gene, resulting in inhibition and/or reduction of S100A4-induced cell motility, invasiveness, metastasis and proliferation of human cancer cells.
    Type: Application
    Filed: April 18, 2012
    Publication date: October 2, 2014
    Applicant: MAXDELBRUCK-CENTRUM FUR MOLEKULARE MEDIZIN
    Inventors: Ulrike Stein, Wolfgang Walther, Ulrike Sack, Robert Shoemaker, Dominic Scudiero, Peter M Schlag
  • USE OF A DNA EXPRESSION CONSTRUCT
    Publication number: 20130273084
    Abstract: The present invention relates to the use of a DNA expression construct comprising a dumbbell-shaped circular strand of deoxyribonucleic acids and provides such a construct with a double-stranded stem and single-stranded loops located at both ends of the stem, wherein the stem comprises complementary deoxyribonucleic acids of the circular strand with a promotor sequence, a coding sequence and a termination signal to be administered by jet injection for the treatment of cancer.
    Type: Application
    Filed: September 8, 2011
    Publication date: October 17, 2013
    Applicant: MOLOGEN AG
    Inventors: Wolfgang Walther, Peter M. Schlag, Dennis Kobelt, Manuel Schmidt