Abstract: Provided herein is a one-step method for chelating actinium-225 to a construct comprising a chelator linked to a biomolecule, such as, an antibody or monoclonal antibody, via a bifunctional ligand in, for example, a 3-arm configuration. Also provided are methods for increasing the radiochemical yield of an actinium-225-chelant-biomolecule complex and for producing a high specific activity actinium-225 complex. The chelation is performed at a physiological temperature, about 37° C. Also provided are high specific activity actinium-225 complexes, that is, actinium-225 chelated to the chelator-biomolecule construct and pharmaceutical compositions thereof. Further provided are methods of treating a neoplastic disease or disorder with the actinium-225 complexes.

Abstract: The present disclosure includes systems and methods for extracting a target element, such as lithium, from a brine. For example, some aspects include a method of extracting lithium including mixing a first brine with an extraction agent to form a first solution having a lithium complex, the lithium complex including lithium bound to the extraction agent. The method can further include extracting the lithium from the first solution and recycling the extraction agent to be used in a further extraction process. In some aspects, extracting the lithium from the first solution includes adsorbing, via an adsorbent media, the lithium complex from the first solution, removing the lithium complex from the adsorbent media, and separating the lithium from the extraction agent in the lithium complex.

Abstract: Provided herein is a one-step method for chelating actinium-225 to a construct comprising a chelator linked to a bio-molecule, such as, an antibody or monoclonal antibody, via a bifunctional ligand in, for example, a 3-arm configuration. Also provided are methods for increasing the radiochemical yield of an actinium-225-chelant-biomolecule complex and for producing a high specific activity actinium-225 complex. The chelation is performed at a physiological temperature, about 37° C. Also provided are high specific activity actinium-225 complexes, that is, actinium-225 chelated to the chelator-biomolecule construct and pharmaceutical compositions thereof. Further provided are methods of treating a neoplastic disease or disorder with the actinium-225 complexes.

Abstract: Provided herein is a one-step method for chelating actinium-225 to a construct comprising a chelator linked to a bio-molecule, such as, an antibody or monoclonal antibody, via a bifunctional ligand in, for example, a 3-arm configuration. Also provided are methods for increasing the radiochemical yield of an actinium-225-chelant-biomolecule complex and for producing a high specific activity actinium-225 complex. The chelation is performed at a physiological temperature, about 37° C. Also provided are high specific activity actinium-225 complexes, that is, actinium-225 chelated to the chelator-biomolecule construct and pharmaceutical compositions thereof. Further provided are methods of treating a neoplastic disease or disorder with the actinium-225 complexes.

Abstract: In one embodiment, a method for back-up of data to flash memory is provided. Backed up data is organized into one or more stripes, wherein a stripe comprises a set of pages across all available flash memory devices which have a same block and page address. Responsive to encountering an error in a block of flash memory during back-up of a particular stripe of data, the particular stripe of data is rewritten starting at a next available page address and excluding a page of flash memory for the block having the error. Subsequent stripes of data in the block having the error are written to pages excluding the page of flash memory for the block having the error.

Abstract: In one embodiment, a method for back-up of data to flash memory is provided. Backed up data is organized into one or more stripes, wherein a stripe comprises a set of pages across all available flash memory devices which have a same block and page address. Responsive to encountering an error in a block of flash memory during back-up of a particular stripe of data, the particular stripe of data is rewritten starting at a next available page address and excluding a page of flash memory for the block having the error. Subsequent stripes of data in the block having the error are written to pages excluding the page of flash memory for the block having the error.

Abstract: New bifunctional chelation complexes are described. These are based on the structure of the so-called “TAME-HexA” molecule. The compounds are especially useful for forming chelation complexes with metal ions, including radioisotopes.

Abstract: New bifunctional chelation complexes are described. These are based on the structure of the so-called “TAME-HexA” molecule. The compounds are especially useful for forming chelation complexes with metal ions, including radioisotopes.

Abstract: New bifunctional chelation complexes are described. These are based on the structure of the so-called “TAME-HexA” molecule. The compounds are especially useful for forming chelation complexes with metal ions, including radioisotopes.

Abstract: A barrier panel adapted for operative attachment to a vehicle door panel. The barrier panel includes a main body portion and at least one tab adapted for operative attachment to the vehicle door panel. The tab extends from the main body portion and is removable from the main body portion. Furthermore, the barrier panel may be employed in a vehicle door assembly for facilitating reassembly of the same. A method of manufacturing the vehicle door assembly is also disclosed.

Abstract: A slitting assembly (10) in the preferred form of a rotary cutter includes a shaft (50) upon which relatively thin, large diameter annular blades (56) are slid and held in place on the shaft by relatively large diameter hubs (60). An axial bore (54) is provided through the shaft (50) for circulating a coolant in fluid communication therewith by rotary joints (74, 78). Thus, the blades (56) are cooled below ambient temperature by conduction through hubs (60) and shaft (50) for imparting continuous longitudinal cuts in a band (12) of fat-free brownie products having an internal temperature higher than ambient. The outer periphery of the blades (56) rotate against a back-up roll (22) rotatable about a parallel axis below the band (12). Scrapers (30, 70) are provided to remove any product sticking to the back-up roll (22) and the axial faces of the blades (56).

Abstract: A slitting assembly (10) is disclosed in the preferred form of a rotary cutter including a shaft (50) upon which relatively thin, large diameter annular blades (56) are slid. Relatively large diameter hubs (60) are provided having inner surfaces for receipt on the shaft (50) and having axial ends which flushly abut with the axial faces of the blades (56) for holding the blades (56) in axially spaced relations on the shaft (50). An axial bore (54) is provided through the shaft (50) for circulating a coolant in fluid communication therewith by rotary unions (74, 78). Thus, the blades (56) are cooled below ambient temperature by conduction through hubs (60) and shaft (50) for imparting continuous longitudinal cuts in a band (12) of fat-free brownie products having an internal temperature higher than ambient. The outer periphery of the blades (56) rotate against a back-up roll (22) rotatable about a parallel axis below the band (12).

Abstract: This specification concerns signal processing apparatus for processing line synchronization pulses in a line synchronization signal that define an analog video signal line period. The apparatus comprises a phase locked loop (40) for generating a clock signal of a frequency that is a multiple of the line synchronization signal frequency. The phase locked loop (40) comprises a counter (100) for dividing the clock signal by said multiple. The apparatus further comprises logic (110,50) for resetting the counter (100) upon detection of a spurious pulse introducing a time interval into the line synchronization signal of less than the line period of the video signal. The apparatus is particularly useful in image processing systems for digitizing analog video signals that have been replayed via a conventional, domestic video tape player, and therefore may comprise spurious line sync pulses introduced by playback head skip.

Abstract: A controller for a first in first out (FIFO) memory comprises detector logic for detecting any difference between the number of addresses in the memory into which data is written and the number of addresses in the memory from which data is read. Comparator logic connected to the detector logic generates a request data transfer signal in response to said difference becoming greater than or equal to a threshold. Threshold select logic connected to the comparator logic is responsive to data having first and second portions being written to the memory. The threshold select logic sets the threshold to a first value when the first portion is being written and sets the threshold to a second value, greater than the first value, when the second portion is being written.

Abstract: Signal processing apparatus comprises a chrominance subsampler (10) for sampling the U and V components of a PAL video signal in response to an enable signal. A counter (30) responsive to the horizontal synchronization component of the PAL video signal generates the enable signal upon detection of a predetermined number of horizontal synchronization pulses. Logic (60,70,80) responsive to the vertical synchronization component of the PAL video signal resets and disables the counter (30) upon detection of a vertical synchronization pulse. Logic (50,60,70,80) restarts the counter (30) from a reset state upon detection of a predetermined polarity in the V component of the PAL video signal.