Patents by Inventor Peter M. Smith-Jones

Peter M. Smith-Jones has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • One-Step Labeling of Antibodies to High Specific Activity with Actinium-225
    Publication number: 20230364276
    Abstract: Provided herein is a one-step method for chelating actinium-225 to a construct comprising a chelator linked to a biomolecule, such as, an antibody or monoclonal antibody, via a bifunctional ligand in, for example, a 3-arm configuration. Also provided are methods for increasing the radiochemical yield of an actinium-225-chelant-biomolecule complex and for producing a high specific activity actinium-225 complex. The chelation is performed at a physiological temperature, about 37° C. Also provided are high specific activity actinium-225 complexes, that is, actinium-225 chelated to the chelator-biomolecule construct and pharmaceutical compositions thereof. Further provided are methods of treating a neoplastic disease or disorder with the actinium-225 complexes.
    Type: Application
    Filed: April 24, 2023
    Publication date: November 16, 2023
    Applicant: Sloan-Kettering Institute for Cancer Research
    Inventors: David A. Scheinberg, Peter M. Smith-Jones, Michael R. McDevitt, William F. Maguire
  • One-step labeling of antibodies to high specific activity with actinium-225
    Patent number: 11660357
    Abstract: Provided herein is a one-step method for chelating actinium-225 to a construct comprising a chelator linked to a bio-molecule, such as, an antibody or monoclonal antibody, via a bifunctional ligand in, for example, a 3-arm configuration. Also provided are methods for increasing the radiochemical yield of an actinium-225-chelant-biomolecule complex and for producing a high specific activity actinium-225 complex. The chelation is performed at a physiological temperature, about 37° C. Also provided are high specific activity actinium-225 complexes, that is, actinium-225 chelated to the chelator-biomolecule construct and pharmaceutical compositions thereof. Further provided are methods of treating a neoplastic disease or disorder with the actinium-225 complexes.
    Type: Grant
    Filed: May 18, 2015
    Date of Patent: May 30, 2023
    Inventors: David A. Scheinberg, Peter M. Smith-Jones, Michael R. McDevitt, William F. Maguire
  • One-Step Labeling of Antibodies to High Specific Activity with Actinium-225
    Publication number: 20170112951
    Abstract: Provided herein is a one-step method for chelating actinium-225 to a construct comprising a chelator linked to a bio-molecule, such as, an antibody or monoclonal antibody, via a bifunctional ligand in, for example, a 3-arm configuration. Also provided are methods for increasing the radiochemical yield of an actinium-225-chelant-biomolecule complex and for producing a high specific activity actinium-225 complex. The chelation is performed at a physiological temperature, about 37° C. Also provided are high specific activity actinium-225 complexes, that is, actinium-225 chelated to the chelator-biomolecule construct and pharmaceutical compositions thereof. Further provided are methods of treating a neoplastic disease or disorder with the actinium-225 complexes.
    Type: Application
    Filed: May 18, 2015
    Publication date: April 27, 2017
    Applicant: Sloan-Kettering Institute for Cancer Research
    Inventors: David A. Scheinberg, Peter M. Smith-Jones, Michael R. McDevitt, William F. Maquire
  • Tame based chelators and uses thereof
    Patent number: 8173102
    Abstract: New bifunctional chelation complexes are described. These are based on the structure of the so-called “TAME-HexA” molecule. The compounds are especially useful for forming chelation complexes with metal ions, including radioisotopes.
    Type: Grant
    Filed: July 7, 2010
    Date of Patent: May 8, 2012
    Assignees: Sloan-Kettering Institute for Cancer Research, Ludwig Institute for Cancer Research
    Inventors: Enver Arslantas, Richard R. Schmidt, Peter M. Smith-Jones, Gerd Ritter
  • Tame based chelators and uses thereof
    Publication number: 20100324319
    Abstract: New bifunctional chelation complexes are described. These are based on the structure of the so-called “TAME-HexA” molecule. The compounds are especially useful for forming chelation complexes with metal ions, including radioisotopes.
    Type: Application
    Filed: July 7, 2010
    Publication date: December 23, 2010
    Inventors: Enver ARSLANTAS, Richard R. SCHMIDT, Peter M. SMITH-JONES, Gerd RITTER
  • Tame based chelators and uses thereof
    Patent number: 7780947
    Abstract: New bifunctional chelation complexes are described. These are based on the structure of the so-called “TAME-HexA” molecule. The compounds are especially useful for forming chelation complexes with metal ions, including radioisotopes.
    Type: Grant
    Filed: December 3, 2004
    Date of Patent: August 24, 2010
    Assignees: Sloan-Kettering Institute for Cancer Research, Ludwig Institute for Cancer Research
    Inventors: Enver Arslantas, Richard R. Schmidt, Peter M. Smith-Jones, Gerd Ritter