Abstract: A monitoring device for a high-voltage onboard electrical system of an electrically operable vehicle. The high-voltage onboard electrical system includes a high-voltage energy storage device that is couplable to an electrically positive and an electrically negative charge line. The electrically positive charge line is couplable to a positive electric voltage of a charging device via a charging connection to charge the high-voltage energy storage device and the electrically negative charge line is couplable to a negative electric voltage of the charging device to charge the high voltage energy storage device. The monitoring device has a control unit with a current sensor which is configured to determine the sum of the electric currents of the positive and the negative charge lines. The control unit is configured to separate the positive and the negative charge lines from the high-voltage onboard electrical system upon detecting a fault.

Abstract: Herein is reported a method for producing a fusion-polypeptide comprising the seeps of a) cultivating a mammalian cell comprising a nucleic acid encoding a variant fusion-polypeptide wherein the amino acid sequence of the fusion-polypeptide has been modified by replacing in a pro-fusion-polypeptide the endogenous protease cleavage site between the pro-peptide and the fusion-polypeptide with an exogenous (with respect to the origins of the parts of the fusion-polypeptide) or artificial protease cleavage site, and b) recovering the fusion-polypeptide or fusion-pro-polypeptide from the cell or the cultivation median and thereby producing the (recombinant) fusion-polypeptide.

Abstract: A connection apparatus for electrically connecting a stored energy source to an electrical device having an electric drive motor, wherein the connection apparatus is part of the stored energy source or of the electrical device and can be connected to a connection apparatus of the electrical device or of the stored energy source, wherein the connection apparatuses have plug contours and counter plug contours, by means of which the stored energy source is interlockingly fastened to the electrical device in a fastening position, in which at least two electrical connections between the electrical device and the stored energy source having different potential, are each established by means of a pair of base contact elements and base counter contact elements of the connection apparatuses, said contact elements being in contact with each other, for the supply of electrical energy to the electrical device by the stored energy source.

Abstract: A connection apparatus for electrically connecting a stored energy source to an electrical device having an electric drive motor, wherein the connection apparatus is part of the stored energy source or of the electrical device and can be connected to a connection apparatus of the electrical device or of the stored energy source, wherein the connection apparatuses have plug contours and counter plug contours, by means of which the stored energy source is interlockingly fastened to the electrical device in a fastening position, in which at least two electrical connections between the electrical device and the stored energy source having different potential, are each established by means of a pair of base contact elements and base counter contact elements of the connection apparatuses, said contact elements being in contact with each other, for the supply of electrical energy to the electrical device by the stored energy source.

Abstract: The present invention relates to blood brain barrier shuttles that bind receptors on the blood brain barrier (R/BBB) and methods of using the same.

Abstract: Herein is reported a method for producing a fusion-polypeptide comprising the seeps of a) cultivating a mammalian cell comprising a nucleic acid encoding a variant fusion-polypeptide wherein the amino acid sequence of the fusion-polypeptide has been modified by replacing in a pro-fusion-polypeptide the endogenous protease cleavage site between the pro-peptide and the fusion-polypeptide with an exogenous (with respect to the origins of the parts of the fusion-polypeptide) or artificial protease cleavage site, and b) recovering the fusion-polypeptide or fusion-pro-polypeptide from the cell or the cultivation median and thereby producing the (recombinant) fusion-polypeptide.

Abstract: Herein is reported a method for producing a fusion-polypeptide comprising the steps of a) cultivating a mammalian cell comprising a nucleic acid encoding a variant fusion-polypeptide wherein the amino acid sequence of the fusion-polypeptide has been modified by replacing in a pro-fusion-polypeptide the endogenous protease cleavage site between the pro-peptide and the fusion-polypeptide with an exogenous (with respect to the origins of the parts of the fusion-polypeptide) or artificial protease cleavage site, and b) recovering the fusion-polypeptide or fusion-pro-polypeptide from the cell or the cultivation medium and thereby producing the (recombinant) fusion-polypeptide.

Abstract: A robot device having a driven unit is proposed, wherein the driven unit is conceived for approaching surfaces. The driven unit according to the present invention is covered with a protective layer from a coating material which is electrically conductive and has a thickness of at least 4 millimeters.

Abstract: Herein is reported a method for producing a fusion-polypeptide comprising the steps of a) cultivating a mammalian cell comprising a nucleic acid encoding a variant fusion-polypeptide wherein the amino acid sequence of the fusion-polypeptide has been modified by replacing in a pro-fusion-polypeptide the endogenous protease cleavage site between the pro-peptide and the fusion-polypeptide with an exogenous (with respect to the origins of the parts of the fusion-polypeptide) or artificial protease cleavage site, and b) recovering the fusion-polypeptide or fusion-pro-polypeptide from the cell or the cultivation medium and thereby producing the (recombinant) fusion-polypeptide.

Abstract: The present invention relates to blood brain barrier shuttles that bind receptors on the blood brain barrier (R/BBB) and methods of using the same.

Abstract: A method and apparatus for forming stacks of printed products supplied in an overlapping flow by an endless conveyor to a stacking shaft. A main stack is formed on a stack support in the stacking shaft. An auxiliary rake is moved from an idle position outside of the stacking shaft to an end position inside the stacking shaft. The stack support is lowered to form an intermediate space below the auxiliary rake between the main stack and a partial stack. An intermediate element is extended into the intermediate space to an end position in the stacking shaft. The printed products are deposited on the intermediate element or on previously deposited printed products, wherein a partial stack forms on the intermediate element. The main stack is carried away from the stacking shaft and the auxiliary rake is retracted to its idle position.

Abstract: Disclosed is a tailgate, especially for a vehicle, comprising a platform (1) which is joined to a lifting/lowering mechanism (11) via at least one arm (2.1, 2.2). The platform (1) forms a rotary shaft (A) along with the support arm (2.1, 2.2) while the support arm (2.1, 2.2) forms a swiveling shaft (S) along with the lifting/lowering mechanism (11). A motor (3, 13) is to be allocated to the rotary shaft (A) and/or the swiveling shaft (S).

Abstract: A method and apparatus for forming stacks of printed products supplied in an overlapping flow by an endless conveyor to a stacking shaft. A main stack is formed on a stack support in the stacking shaft. An auxiliary rake is moved from an idle position outside of the stacking shaft to an end position inside the stacking shaft. The stack support is lowered to form an intermediate space below the auxiliary rake between the main stack and a partial stack. An intermediate element is extended into the intermediate space to an end position in the stacking shaft. The printed products are deposited on the intermediate element or on previously deposited printed products, wherein a partial stack forms on the intermediate element. The main stack is carried away from the stacking shaft and the auxiliary rake is retracted to its idle position.

Abstract: The invention relates to a method for the presence detection of microorganisms in a bioreactor (B), to a bioreactor (B), and to an arrangement for performing the detection method.

Abstract: A chair with a tilting seat and a back piece carried by a back support, wherein a bearing block is provided, in which an eccentric cam can rotate, a rod passes eccentrically through the eccentric cam and is connected to it without the ability to rotate, and at one end it is connected to a handle by which it can be turned. An arm is provided in which the rod is mounted such that it can turn. The tilting of the seat can be adjusted in more than just two positions and the adjustments are secured against unintentional change. The bearing block is provided on the back support and the arm on the bottom side of the seat, a detent sleeve is joined to the aforementioned end of the rod, unable to rotate, but able to slide along the rod between a first and a second position.

Abstract: A back rest for a chair with a back support and a back surface secured to the back support and able to swivel about a two-axis joint. The joint has a joint plate connected to the back surface, an element made of an elastic material that supports the joint in a ground position, and a chamber to accommodate the elastic element, connected to the back support. The joint plate is arranged in the receiving chamber between two elements made from an elastic material, holding the joint in a ground position and each being supported against the receiving chamber, and it can swivel about the two swivel axes. When the joint is placed under load, the two elastic elements are only subjected to compression. There are no tension-loaded connections which break under loading and can result in the joint falling apart.

Abstract: Disclosed is a tailgate, especially for a vehicle, comprising a platform (1) which is joined to a lifting/lowering mechanism (11) via at least one arm (2.1, 2.2). The platform (1) forms a rotary shaft (A) along with the support arm (2.1, 2.2) while the support arm (2.1, 2.2) forms a swiveling shaft (S) along with the lifting/lowering mechanism (11). A motor (3, 13) is to be allocated to the rotary shaft (A) and/or the swiveling shaft (S).

Abstract: A back rest for a chair with a back support and a back surface secured to the back support and able to swivel about a two-axis joint. The joint has a joint plate connected to the back surface, an element made of an elastic material that supports the joint in a ground position, and a chamber to accommodate the elastic element, connected to the back support. The joint plate is arranged in the receiving chamber between two elements made from an elastic material, holding the joint in a ground position and each being supported against the receiving chamber, and it can swivel about the two swivel axes. When the joint is placed under load, the two elastic elements are only subjected to compression. There are no tension-loaded connections which break under loading and can result in the joint falling apart.

Abstract: A chair with a tilting seat and a back piece carried by a back support, wherein a bearing block is provided, in which an eccentric cam can rotate, a rod passes eccentrically through the eccentric cam and is connected to it without the ability to rotate, and at one end it is connected to a handle by which it can be turned. An arm is provided in which the rod is mounted such that it can turn. The tilting of the seat can be adjusted in more than just two positions and the adjustments are secured against unintentional change. The bearing block is provided on the back support and the arm on the bottom side of the seat, a detent sleeve is joined to the aforementioned end of the rod, unable to rotate, but able to slide along the rod between a first and a second position.

Abstract: Described is a process for lightening or partially decolorizing vat- or sulfur-dyed textile materials, which comprises treating the material with aminoalkanesulfinic acids in a neutral or weakly acidic medium, and preparations of the aminoalkanesulfinic acids for carrying out this process.