Abstract: The present invention is directed to kinase inhibitor compounds having the following structure: or a stereoisomer, pharmaceutically acceptable salt, oxide, or solvate thereof, where R1, R2, X, n, R3, Y, Z, R4, R5, R6, and = are as defined herein. The present invention also relates to compositions containing the kinase inhibitor compounds, methods of inhibiting activity of a kinase in a cell, methods of increasing cell proliferation in a population of pancreatic beta cells, methods of treating a subject for a condition associated with insufficient insulin secretion, and methods of treating a subject for a neurological disorder.

Abstract: Different processor architectures are described to evaluate and track dependencies required by instructions. The processors may hold or queue instructions that require output of other instructions until required data and resources are available which may remove the requirement of NOPs in the instruction memory to resolve dependencies and pipeline hazards. The processor may divide instruction data into bundles for parallel execution and provide speculative execution. The processor may include various components to implement an evaluation unit, execution unit and termination unit.

Abstract: The processor chip can have a pre-execution pipeline sharing a plurality of resources including at least one resource of interest, a resource tracker having more than one credit unit associated with each one of said at least one resource of interest. The method can include: decoding the instruction data to determine a resource requirement including a quantity of virtual credits required from the credit units for the at least one resource of interest, checking the resource tracker for an availability of said quantity of virtual credits and, if the availability of the amount of said virtual credits is established, i) dispatching the instruction data, and ii) subtracting the quantity of said credits from the resource tracker.

Abstract: The method can be performed in a processor integrated circuit having an instruction decoder and a plurality of shared resources, a resource tracker circuit having a plurality of credit units associated with corresponding ones of the shared resources in a manner to be updatable based on availability of the shared resources, and a resource matcher connected to receive a resource requirement signal from the decoder and connected to receive a resource availability signal from the resource tracker. The method can include performing a determination of whether or not the resource requirement signal matches the resource availability signal, and, upon a positive determination, dispatching corresponding instruction data, updating the status of a corresponding one or more of the credit units, and preventing the resource matcher from performing a subsequent determination for a given period of time after the positive determination.

Abstract: The present invention is directed to kinase inhibitor compounds having the following structure: or a stereoisomer, pharmaceutically acceptable salt, oxide, or solvate thereof, where R1, R2, X, n, R3, Y, Z, R4, R5, R6, and = are as defined herein. The present invention also relates to compositions containing the kinase inhibitor compounds, methods of inhibiting activity of a kinase in a cell, methods of increasing cell proliferation in a population of pancreatic beta cells, methods of treating a subject for a condition associated with insufficient insulin secretion, and methods of treating a subject for a neurological disorder.

Abstract: The method can be performed in a processor integrated circuit having an instruction decoder and a plurality of shared resources, a resource tracker having a plurality of credit units associated to corresponding ones of the shared resources in a manner to be updatable based on availability of the shared resources, a resource matcher connected to receive a resource requirement signal from the decoder and connected to receive a resource availability signal from the resource tracker. The method can include: performing a determination of whether or not the resource requirement signal matches the resource availability signal, and, upon a positive determination, dispatching a corresponding instruction data, updating the status of a corresponding one or more of the credit units, and preventing the resource matcher from performing a subsequent determination for given period of time after the positive determination.

Abstract: A system and method for multi-branch switching are provided. A memory has stored therein a program comprising at least one sequence of instructions, the at least one sequence of instructions comprising a plurality of branch instructions, at least one branch of the program reached upon execution of each one of the plurality of branch instructions. The processor is configured for fetching the plurality of branch instructions from the memory, separately buffering each branch of the program associated with each one of the fetched branch instructions, evaluating the fetched branch instructions in parallel, and executing the evaluated branch instructions in parallel.

Abstract: Different processor architectures are described to evaluate and track dependencies required by instructions. The processors may hold or queue instructions that require output of other instructions until required data and resources are available which may remove the requirement of NOPs in the instruction memory to resolve dependencies and pipeline hazards. The processor may divide instruction data into bundles for parallel execution and provide speculative execution. The processor may include various components to implement an evaluation unit, execution unit and termination unit.

Abstract: The processor chip can have a pre-execution pipeline sharing a plurality of resources including at least one resource of interest, a resource tracker having more than one credit unit associated to each one of said at least one resource of interest. The method can include: decoding the instruction data to determine a resource requirement including a quantity of virtual credits required from the credit units for the at least one resource of interest, checking the resource tracker for an availability of said quantity of virtual credits and, if the availability of the amount of said virtual credits is established, i) dispatching the instruction data, and ii) subtracting the quantity of said credits from the resource tracker.

Abstract: A wearable robotic device for the rehabilitation training of a limb with moisture and pressure management functions. Such wearable robotic device comprises a motor rotation system and a bracing system, wherein the motor rotation system comprises a motor and a motor control system; and the bracing system comprises a framework of structural members that is attachable to and detachable from the limb, one or more textile bracing cushions and one or more fastening belts attached to each of the textile bracing cushions such that the fastening belts and the textile bracing cushions in combination are capable of attaching the wearable robotic device onto the limb.

Abstract: A head-mountable EEG electrode-containing device is provided based on radially adjustable electrodes to fit the wearer's unique head size and shape. The head-mountable device with an electrode array positioned therein includes multiple head-mountable device sections that are interconnected by mechanical fasteners to facilitate sizing and positioning of the head-mountable device. An array of resilient sleeves is positioned within each head-mountable device section. Each resilient sleeve houses an individual electrode and is deformable for self-orienting. The deformation of the sleeve is such that a central axis passing through the individual electrode housed within the resilient sleeve is maintained in a position approximately normal to a plane tangential to a scalp portion positioned beneath that electrode.

Abstract: A method and a system is provided for Coordinate Rotation Digital Computer (CORDIC) based matrix inversion of input digital signal streams from multiple antennas using an bi-directional ring-bus architecture. The bi-directional ring bus includes a first ring bus having signals flow in a clockwise direction, and a second ring bus having signals flow in a counter-clockwise direction. An I/O controller is coupled to the first and the second ring bus, respectively. A plurality of processing elements (PEs), where each of the plurality of PEs is coupled to the first and the second ring bus, respectively, wherein each of the plurality of PEs includes at least one CORDIC core for performing CORDIC iterations on the plurality of input digital stream signals to produce inversed matrix signals.

Abstract: A method and a system is provided for Coordinate Rotation Digital Computer (CORDIC) based matrix inversion of input digital signal streams from multiple antennas using an bi-directional ring-bus architecture. The bi-directional ring bus includes a first ring bus having signals flow in a clockwise direction, and a second ring bus having signals flow in a counter-clockwise direction. An I/O controller is coupled to the first and the second ring bus, respectively. A plurality of processing elements (PEs), where each of the plurality of PEs is coupled to the first and the second ring bus, respectively, wherein each of the plurality of PEs includes at least one CORDIC core for performing CORDIC iterations on the plurality of input digital stream signals to produce inversed matrix signals.

Abstract: A head-mountable EEG electrode-containing device is provided based on radially adjustable electrodes to fit the wearer's unique head size and shape. The head-mountable device with an electrode array positioned therein includes multiple head-mountable device sections that are interconnected by mechanical fasteners to facilitate sizing and positioning of the head-mountable device. An array of resilient sleeves is positioned within each head-mountable device section. Each resilient sleeve houses an individual electrode and is deformable for self-orienting. The deformation of the sleeve is such that a central axis passing through the individual electrode housed within the resilient sleeve is maintained in a position approximately normal to a plane tangential to a scalp portion positioned beneath that electrode.

Abstract: A rehabilitation system for training hand movement of a user, the system comprising: a platform to be attached to the hand of the user; a plurality of finger assemblies operatively connected to the platform, each finger assembly having: a motor, a proximal follower assembly for a metacarpophalangeal (MCP) joint having a proximal rail guide operatively connected to the motor, and an intermediate follower assembly for a proximal interphalangeal (PIP) joint having an intermediate rail guide operatively connected to the proximal follower assembly; wherein a knuckle joint indicator of the proximal rail guide corresponds to a first virtual center and knuckle joint indicator of the intermediate rail guide corresponds to a second virtual center, the alignment of the knuckle joint indicators to the virtual centers enable motion of the finger to be controlled and maintain rotational axes of the finger about each virtual center when the proximal and intermediate follower assemblies are actuated by the motor.

Abstract: A rehabilitation system (10) for training hand movement of a user, the system comprising: a platform (24) to be attached to the hand of the user; a plurality of finger assemblies (71) operatively connected to the platform (24), each finger assembly (71) having: a motor (12), a proximal follower assembly (13) for a metacarpophalangeal (MCP) joint having a proximal rail guide (14) operatively connected to the motor (12), and an intermediate follower assembly (16) for a proximal interphalangeal (PIP) joint having an intermediate rail guide (17) operatively connected to the proximal follower assembly (13); wherein a knuckle joint indicator (22) of the proximal rail guide (14) corresponds to a first virtual center (30) and knuckle joint indicator (25) of the intermediate rail guide (17) corresponds to a second virtual center (31), the alignment of the knuckle joint indicators (22, 25) to the virtual centers (30, 31) enable motion of the finger to be controlled and maintain rotational axes of the finger about each

Abstract: A toy vehicle has hinged and lockable doors, trunk lid, and hood, each with an internal U-shaped shackle, clevis, or claw projecting inwardly. A single locking plate is slidably positioned inside the vehicle. The plate has an integral sliding bolt at each position which is adjacent a shackle, clevis, or claw. The internal hub of each wheel has an integral, cam shaped member formed thereon to be captured or released by detents on the locking plate. A key fits through a key hole in the bottom of the vehicle in order to slide the plate forward or aft, as the key turns. As it so slides, a bolt or detent on the plate slides through or out of each shackle, clevis, or claw and engages or disengages the cam members, thereby locking or unlocking the doors and wheels.