Patents by Inventor Peter Matyus

Peter Matyus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190365732
    Abstract: Provided is a topical pharmaceutical gel composition of an amlodipine salt and methods for its use in the treatment of anorectal disease.
    Type: Application
    Filed: May 29, 2019
    Publication date: December 5, 2019
    Inventors: László RITTER, László HORNOK, Péter MÁTYUS, Romána ZELKÓ, Andrea UJHELYI, Richárd Balázs KÁRPÁTI, Tamás SOLYMOSI, Hristos GLAVINAS
  • Patent number: 9790193
    Abstract: The invention relates to a compound having SSAO/VAP-1 inhibitor activity for use in the treatment of hyperalgesia and allodynia implicated in traumatic neuropathy or neurogenic inflammation. Accordingly, the invention relates to a compound having SSAO/VAP-1 inhibitor activity for use in the inhibition of pathological activation and dysfunctions of peptidergic sensory nerves caused by mechanical damage or chemical activation of peptidergic sensory nerves in neurogenic inflammation.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: October 17, 2017
    Assignee: PÉCSI TUDOMÁNYEGYETEM
    Inventors: Zsuzsanna Tamasikné Helyes, Valéria Dezsö-Tékus, Bálint Scheich, Péter Mátyus
  • Publication number: 20170044117
    Abstract: The invention relates to a compound having SSAO/VAP-1 inhibitor activity for use in the treatment of hyperalgesia and allodynia implicated in traumatic neuropathy or neurogenic inflammation. Accordingly, the invention relates to a compound having SSAO/VAP-1 inhibitor activity for use in the inhibition of pathological activation and dysfunctions of peptidergic sensory nerves caused by mechanical damage or chemical activation of peptidergic sensory nerves in neurogenic inflammation.
    Type: Application
    Filed: December 18, 2014
    Publication date: February 16, 2017
    Inventors: Zsuzsanna Andor TAMASIKNÉ HELYES, Valéria DEZSÖ-TÉKUS, Bálint SCHEICH, Péter MÁTYUS
  • Publication number: 20150150842
    Abstract: The invention relates to a pharmaceutical composition comprising a compound selected from the group consisting of desethylamiodarone and pharmaceutically acceptable salts, hydrates and solvates thereof, together with pharmaceutically acceptable excipients, vehicle and/or carrier, as well as the pharmaceutical composition for use in the treatment and prevention of atrial fibrillation with fewer side effects than its parent compound.
    Type: Application
    Filed: June 14, 2013
    Publication date: June 4, 2015
    Applicant: SZEGEDI TUDOMÁNYEGYETEM
    Inventors: András Varró, Péter Mátyus, István Baczkó, György Falkay, Norbert Jost, István Leprán, Anita Sztojkov-Ivanov, László Virág, Norbert Buzás
  • Patent number: 8536210
    Abstract: The present invention relates to compounds of general formula (i) having an oxime moiety or a pharmaceutically acceptable salt, hydrate or solvate thereof and its use for inhibiting semicarbazide-sensitive amine oxidase (SSAO), also known as vascular adhesion protein-1 (VAP-1), a pharmaceutical composition comprising the compound or a salt, hydrate or solvate thereof as an active ingredient, a method for the prevention or the treatment of a SSAO/VAP-1 related disease, said diseases including acute or chronic inflammatory diseases, diseases related to carbohydrate metabolism, diabetes-associated complications, diabetic retinopathy and macular oedema, diseases related to adipocyte or smooth muscle dysfunctions, neurodegenerative diseases and vascular diseases.
    Type: Grant
    Filed: September 11, 2009
    Date of Patent: September 17, 2013
    Assignee: Semmelweis Egyetem
    Inventors: Péter Mátyus, Kálmán Magyar, Marjo Pihlavisto, Klára Gyires, Norbert Haider, Yinghua Wang, Patrick Woda, Petra Dunkel, Éva Tóth-Sarudy, György Túrós
  • Publication number: 20110263567
    Abstract: The present invention relates to compounds of general formula (i) having an oxime moiety or a pharmaceutically acceptable salt, hydrate or solvate thereof and its use for inhibiting semicarbazide-sensitive amine oxidase (SSAO), also known as vascular adhesion protein-1 (VAP-1), a pharmaceutical composition comprising the compound or a salt, hydrate or solvate thereof as an active ingredient, a method for the prevention or the treatment of a SSAO/VAP-1 related disease, said diseases including acute or chronic inflammatory diseases, diseases related to carbohydrate metabolism, diabetes-associated complications, diabetic retinopathy and macular oedema, diseases related to adipocyte or smooth muscle dysfunctions, neurodegenerative diseases and vascular diseases.
    Type: Application
    Filed: September 11, 2009
    Publication date: October 27, 2011
    Applicant: Semmelweis Egyetem
    Inventors: Péter Mátyus, Kálmán Magyar, Marjo Pihlavisto, Klára Gyires, Norbert Haider, Yinghua Wang, Patrick Woda, Petra Dunkel, Éva Tóth-Sarudy, Gÿorgy Túrós
  • Patent number: 6602865
    Abstract: Pyridazino(4,5-b)(1,5)oxazepinone, thiazepinone and diazepinone compounds of formula(I) and their tautomers and the acid-addition salts of all these compounds show memory-enhancing and neuroprotective properties.
    Type: Grant
    Filed: November 15, 1999
    Date of Patent: August 5, 2003
    Assignee: IVAX Drug Research Institute, Ltd.
    Inventors: Ferenc Andrasi, Agnes Angyal nee Pataky, Pal Berzsenyi, Sandor Boros, Laszlo Harsing, Katalin Horvath, Peter Matyus, Imre Moravcsik, Agnes Papp nee Behr, Antal Simay, Erzsebet Szabo nee Bagdy, Katalin Szabo nee Pusztai, Istvan Tarnawa, Ildiko Varga
  • Patent number: 6265445
    Abstract: The present invention relates to novel, antiarrhythmically active phenoxyalkylamine derivatives possessing a double point of attack. More particularly, the present invention relates to new phenoxyalkylamine derivatives of the formula (1) wherein R1 and R2, independently from each other, mean hydrogen, halogen or C1-4 alkyl group; R3, R4 and R5, independently from each other, stand for hydrogen or C1-4 alkyl group; R6 represents hydrogen, C1-4 alkyl or benzyl group; R7 means nitro group or amino group optionally monosubstituted by C1-4 alkyl, benzoyl, C1-4 alkylcarbonyl, C1-4 alkylsulfonyl, C1-4 alkylcarbamoyl or C1-4 alkylthiocarbamoyl group; both n and m are 0 or 1, with the proviso that R2 is different from hydrogen, when R1 is hydrogen, as well as stereoisomers or mixtures of stereoisomers thereof, acid addition salts thereof and hydrates, prodrugs and metabolites of all these compounds.
    Type: Grant
    Filed: July 28, 2000
    Date of Patent: July 24, 2001
    Assignees: Gyogyszerkutato Intezet Kft, Szent-Gyorgyi Albert Orvostudomanyi Egyetem
    Inventors: Gyula Papp, András Varró, Péter Mátyus, Ildikó Varga, Tivadar Rettegi, Alice Druga, Antal Simay, Imre Moravcsik, Pál Berzsenyi, Daniella Barlocco, Giorgio Cignarella, Márta Pátfalusi
  • Patent number: 6248907
    Abstract: The invention relates to R-2-[3-([1,4]benzodioxan-2-ylmethylamino)-1-propyl]-3(2H)-pyridazinone of formula (1), and to S-2-[3-([1,4]benzodioxan-2-ylmethylamino)-1-propyl]-3(2H)-pyridazinone of formula (2), and to acid-addition salts thereof as well as pharmaceutical compositions containing these compounds. Furthermore, the invention relates to a process for the preparation of the above compounds. The new starting compounds of formulae (4) and (5) are also involved in the scope of the invention. The compounds according to the invention possess &agr;1- and &agr;2-adrenoceptor antagonistic effects and urogenital selectivity. Thus, they are useful for the treatment of the benign prostate hyperplasia.
    Type: Grant
    Filed: August 28, 2000
    Date of Patent: June 19, 2001
    Assignee: Gyogyszerkutato Intezet Kft.
    Inventors: Péter Mátyus, László Hársing, Marianne Tapfer née Karim, Judit Kosáry, Ágnes Papp née Behr, Antal Simay, Yemane Tilahun, Éva Tomori née Joszt, Edit Horváth, Katalin Horváth, Ildikó Varga, Erzsébet Zára née Kaczián, Margit Bidló née Iglóy, Alice Druga, György Rabloczky, Márta Varga, Egon Kárpáti, Endre Kasztreiner, István Király, Ildikó Máthé née Gyóry, György Máthé, László Sebestyén, Nándor Makk
  • Patent number: 6194411
    Abstract: The invention relates to R-2-[3-([1,4]benzodioxan-2-ylmethylamino)-1-propyl]-3(2H)-pyridazionone of formula (1) and to S-2-[3-([1,4]benzodioxan-2-ylmethylamino)-1-propyl]-3(2H)-pyridazionone of formula (2) and to acid-addition salts thereof as well as pharmaceutical compositions containing these compounds. Furthermore, the invention relates to a process for the preparation of the above compounds. The new starting compounds of formula (4) and (5) are also involved in the scope of the invention. The compounds according to the invention possess &agr;1- and &agr;2-adrenoceptor antagonistic effects and urogenital selectivity. Thus, they are useful for the treatment of the benign prostate hyperplasia.
    Type: Grant
    Filed: July 20, 1998
    Date of Patent: February 27, 2001
    Assignee: Gyogyszerkutato Intezet Kft.
    Inventors: Péter Mátyus, László Hársing, Mariann née Tapfer Karim, Judit Kosáry, Ágnes née Behr Papp, Antal Simay, Yemane Tilahun, Éva née Joszt Tomori, Edit Horváth, Katalin Horváth, Ildikó Varga, Erzsébet née Kaczián Zára, Margit née Iglóy Bidló, Alice Druga, György Rabloczky, Márta Varga, Egon Kárpáti, Endre Kasztreiner, István Király, Ildikó née Gyóry Máthé, György Máthé, László Sebestyén, Nándor Makk
  • Patent number: 5854250
    Abstract: An N-benzoylamino acid compound of the formula (I), ##STR1## wherein R.sup.3 is an NR.sup.4 R.sup.5 group where R.sup.4 and R.sup.5 which are the same or different are selected from the group consisting of hydrogen, a hydroxyl group, a C.sub.1-12 alkyl group, a C.sub.1-4 alkyl group substituted by a hydroxyl group and a C.sub.1-4 alkyl group substituted by an amino group;R.sup.4 and R.sup.5 when taken together with the adjacent nitrogen form a substituted or unsubstituted 5- or 6-membered heterocyclic group, a 5- or 6-membered heterocyclic group containing an additional nitrogen atom, a 5- or 6-membered heterocyclic group containing an additional nitrogen atom and being substituted by an oxo group, a phenyl-substituted C.sub.1-4 alkyl group or C.sub.
    Type: Grant
    Filed: August 8, 1997
    Date of Patent: December 29, 1998
    Assignee: Gyogyszerkutato Intezet KFT
    Inventors: Peter Matyus, Erzsebet Zara, Lajos Farkas, Agnes Papp, Antal Simay, Lajos Toldy, Ferenc Andrasi, Katalin Goldschmidt, Eszter Hodula, Ildiko Mathe, Klara Sutka, Zsuzsanna Fittler, Valeria Vitkoczi, Laszlo Sebestyen, Istvan Sziraki, Marta Rusz, Eva Gal
  • Patent number: 5705529
    Abstract: The invention relates to novel N-benzoylamino acid derivatives of the general formula (I), ##STR1## wherein R.sup.1 and R.sup.2, which are the same or different, stand for a hydroxyl group optionally bearing an acetyl group; or a C.sub.1-6 alkoxy group optionally substituted by a phenyl group;n means an integer from 2 to 15as well as their tautomers, racemates and optically active individual (pure) isomers or mixtures thereof and the salts of these compounds and pharmaceutical compositions containing these compounds.The invention relates also to a process for the preparation of compounds of the general formula (I).
    Type: Grant
    Filed: October 11, 1995
    Date of Patent: January 6, 1998
    Assignee: Gyogyszerkutato Intezet KFT
    Inventors: Peter Matyus, Erzsebet Zara, Lajos Farkas, Agnes Papp, Antal Simay, Lajos Toldy, Ferenc Andrasi, Katalin Goldschmidt, Eszter Hodula, Ildiko Mathe, Klara Sutka, Zsuzsanna Fittler, Valeria Vitkoczi, Laszlo Sebestyen, Istvan Sziraki, Marta Rusz, Eva Gal
  • Patent number: 5395934
    Abstract: Racemic or optically active new 3(2H)-pyridazinone derivatives, a process for the preparation thereof, pharmaceutical compositions comprising the same, to the use of the said 3(2H)-pyridazinone derivatives for the treatment of diseases and for the preparation of pharmaceutical compositions suitable for the treatment of diseases.
    Type: Grant
    Filed: December 21, 1992
    Date of Patent: March 7, 1995
    Assignee: EGIS Gyogyszergyar
    Inventors: Peter Matyus, Klara Czako, Ildiko Varga, Andrea Jednakovics, Agnes Papp, Ilona Bodi, Gyorgy Rabloczky, Andras Varro, Laszlo Jaszlits, Aniko Miklos, Luca Levay, Gvorgy Schmidt, Marton Fekete, Maria Kurthy, Katalin Szemeredi, Erzsebet Zara
  • Patent number: 4826845
    Abstract: The invention relates to novel 3(2H)-pyridazinone-derivatives of the general formula (I), pharmaceutical compositions containing them and process for their preparation. In the general formula (I) ##STR1## stands for an ethyl or propyl group substituted by a terminal halogen atom or a hydroxyl or NR.sup.1 R.sup.2 group, whereinR.sup.1 represents hydrogen atom or an unsubstituted or optionally substituted benzyl group;R.sup.2 represents hydrogen atom or an unsubstituted or optionally substituted benzo[1,4]dioxan-2-yl-methyl or -ethyl group or a (CH.sub.2).sub.n --R.sup.3 group, whereinn is 2 or 3; andR.sup.3 stands for an unsubstituted or optionally substituted phenoxy or phenylthio group; andX stands for a hydrogen or halogen atom or an unsubstituted or optionally substituted, saturated or unsaturated 5- or 6-membered heterocyclic group containing a nitrogen atom and optionally an additional heteroatom, e.g.
    Type: Grant
    Filed: October 29, 1986
    Date of Patent: May 2, 1989
    Assignee: Richter Gedeon Vegyeszeti Gyar T.R.
    Inventors: Endre Kasztreiner, Gyorgy Rablocsky, Nandor Makk, Laszlo Jaszlits, Peter Matyus, Gyorgy Cseh, Ildiko Pribusz nee Rapp, Klara Czako, Eszter Diesler, Istvan Elekes, Laszlo Kaufer, Maria Kuhar nee Kurthy, Judit Kincsessy, Judit Kosary, Gyongyi Nagy nee Csokas
  • Patent number: 4748175
    Abstract: The invention relates to novel pyrimido [5,4-b][1,4]oxazine derivatives of the formula (I), and the acid addition salts thereof, pharmaceutical compositions containing them and a process for their preparation. In the formula (I) ##STR1## wherein R.sup.1 stands for a C.sub.1-4 alkyl group;R.sup.2 stands for hydrogen or halogen or an azido group or an --NR.sup.5 R.sup.6 group, whereinR.sup.5 represents hydrogen or a benzyl group, or a C.sub.1-4 alkyl group unsubstituted or substituted by a hydroxyl group,R.sup.6 stands for hydrogen, an amino group, a C.sub.3-6 cycloalkyl group, a straight or branched-chain C.sub.1-4 alkyl group optionally substituted by a hydroxyl, mercapto, aminocarbonyl, furyl, 2-benzo[1,4]dioxanyl, di(C.sub.1-4 alkyl)amino group or by a phenyl or phenoxy group optionally mono- or polysubstituted by halogen or C.sub.1-4 alkoxy group (s) or by a 6-membered, saturated nitrogen-containing heterocycle optionally containing an additional nitrogen or oxygen atom and optionally substituted by a C.
    Type: Grant
    Filed: December 30, 1986
    Date of Patent: May 31, 1988
    Assignee: Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt
    Inventors: Endre Kasztreiner, Gyorgy Rabloczky, Nandor Makk, Gyorgy Cseh, Maria Kuhar nee Kurthy, Eszter Diesler, Laszlo Jaszlits, Laszlo Sebestyen, Janos Wellmann, Aniko Tegdes, Judit Sarossy nee Kincsesy, Peter Matyus, Andras Varro, Laszlo Szam, Sarolta Vegvari nee Gyurki
  • Patent number: 4329457
    Abstract: The invention relates to a novel process for the preparation of 6-(substituted amino)-3-pyridazinylhydrazines having the general formula I ##STR1## and their pharmaceutically acceptable acid addition salts, wherein R.sup.1 stands for hydrogen atom or an alkyl group containing from 1 to 4 carbon atoms;R.sup.2 and R.sup.3 may be the same or different and stand for alkyl groups containing from 1 to 6 carbon atoms, alkenyl groups containing from 2 to 6 carbon atoms, hydroxyalkyl groups containing from 2 to 4 carbon atoms, cycloalkyl groups containing from 3 to 8 carbon atoms, phenyl or benzyl groups or phenyl, benzyl or phenylethyl groups containing one or two halogen atoms, nitro, methoxy or hydroxyl groups, and one of R.sup.2 and R.sup.3 may stand also for a hydrogen atom, or R.sup.2 and R.sup.3 together with the neighboring nitrogen atom may build up also a morpholino, pyrrolidino, piperidino, heptamethyleneimino or N-methylpiperazino group.
    Type: Grant
    Filed: May 6, 1980
    Date of Patent: May 11, 1982
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Geza Szilagyi, Peter Matyus, Endre Kasztreiner, Tibor Balogh, Lajos Ila
  • Patent number: 4308386
    Abstract: Pyridazinylhydrazones capable of lowering blood pressure have the formula ##STR1## wherein R.sup.1 is hydrogen, chlorine, alkyl having from 1 to 4 carbon atoms, methoxy, hydroxyl, carbamoyl or cyano;R.sup.2 is chloro; andK is a group having the formula ##STR2## wherein one of R.sup.3, R.sup.4, R.sup.5 or R.sup.6 is carboxyl or alkoxycarbonyl.
    Type: Grant
    Filed: October 31, 1979
    Date of Patent: December 29, 1981
    Assignee: Richt er Gedeon Vegyeszeti Gyar Rt.
    Inventors: Szilagyi Geza, Endre Kasztreiner, Judit Kosary, Peter Matyus, Zsuzsa Huszti, Gyorgy Cseh, Agnes Kenessey, Laszlo Tardos, Edit Kosa, Laszlo Jaszlits, Sandor Elek, Istvan Elekes, Istvan Polgari
  • Patent number: 4259328
    Abstract: Pyridazinylhydrazones capable of lowering blood pressure having the formula ##STR1## wherein R.sup.1 is hydrogen, chlorine, alkyl having from 1 to 4 carbon atoms, methoxy, hydroxyl, carbamoyl or cyano;R.sup.2 is morpholino; andK is a group having the formula ##STR2## wherein one of R.sup.3, R.sup.4, R.sup.5 or R.sup.6 is carboxyl or alkoxycarbonyl.
    Type: Grant
    Filed: June 12, 1978
    Date of Patent: March 31, 1981
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt
    Inventors: Geza Szilagyi, Endre Kasztreiner, Judit Kosary, Peter Matyus, Zsuzsa Huszti, Gyorgy Cseh, Agnes Kenessey, Laszlo Tardos, Edit Kosa, Laszlo Jaszlits, Sandor Elek, Istvan Elekes, Istvan Polgari