Abstract: A method of generating a radionuclide includes receiving a container in a container receptacle of a radionuclide generator, and moving the container in the container receptacle from a first pose to a second pose. The method also includes exposing an interior surface of the container to a precursor radionuclide source while the container is in the second pose, and allowing sufficient time for the precursor radionuclide source to decay into one or more progeny radionuclides and to emanate the one or more progeny radionuclides into the container. The method further includes isolating the precursor radionuclide source from the container while the container is in the first pose.