Abstract: The present invention primarily relates to a fatty acid ester or mixture of two or more fatty acid esters or mixture comprising one or more fatty acid esters, wherein the fatty acid ester or one, two, three or more, preferably all, of the fatty acid ester(s) is/are selected from the group consisting of 3-hydroxypropyl caprylate, glyceryl monocaprylate, 3-hydroxypropyl undecylenate and glyceryl monoundecylenate, for use in the treatment of an excess of Malassezia on the skin surface of mammals, preferably of humans. The present invention further relates to particular mixtures or products, and to the cosmetic, non-therapeutic use of fatty acid esters or of mixtures or products comprising fatty acid esters as defined herein to reduce the amount of Malassezia on the skin surface of mammals, preferably of humans.

Abstract: The present invention concerns an agent for prevention and treatment of pityriasis. The agent according to the present invention comprises at least one transaminase inhibitor effectively inhibiting the transamination process which is of pathogenetic relevance for the disease, prevents a recurrence of the disease and which protects the human skin flora. Upon release into the environment, no resistances are induced in other fungi.

Abstract: The present invention concerns an agent for prevention and treatment of pityriasis. The agent according to the present invention comprises at least one transaminase inhibitor effectively inhibiting the transamination process which is of pathogenetic relevance for the disease, prevents a recurrence of the disease and which protects the human skin flora. Upon release into the environment, no resistances are induced in other fungi.

Abstract: The invention relates to indole derivatives of formula (I) or (II) for use as inflammation modulators, especially having an inhibitory effect on protein kinases. Formula (I), wherein n=0 or 1, R1=R2=3-indole, R3═COOH— or a ketone, X═O or NH; with the proviso that if n=0, R4═OH and R5=3-indole; and if n=1, R4 together with R5 represents an indole ring system condensed to the structure in the 2,3 position and X═NH. Formula (II), wherein R1=R2=3-indole, X═O, CH2 or a carbonyl group; X═O, a carbonyl group NH or >C═N(R′)2 with R′═CH3 or C2H5. The novel indole derivatives isolated from Melassezia are especially useful as substances for producing a medicament for the treatment of inflammatory or proliferative diseases, especially of the skin, but also of other organ systems.

Abstract: An emulsion containing one or several polyunsaturated, long-chain omega-3 and/or omega-6 fatty acids or their pharmaceutically tolerable esters or salts, as well as usual adjuvants and additives, is used to produce an intravenously administered medicament for treating skin diseases, in particular inflammatory skin diseases, as well as diseases of the dermatitis or eczema group. Preferably, fatty acids containing 18-22 carbon atoms, as well as their pharmaceutically tolerable esters of salts, are used. These acids or their pharmaceutically tolerable esters or salts may be used in their pure form or as components of oils, such as fish oil, highly-purified fish oil concentrates, linseed oil, primrose oil, borage oil or soya oil. Specially preferred are the pharmaceutically tolerable esters or salts of said acids, in particular the pharmaceutically tolerable esters, especially those derived from eicosapentaenic acid.