Abstract: The present invention provides pharmaceutical compositions comprising a compound of formula (I) wherein A, R1, R2 and R3 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the pharmaceutical compositions comprising a compound of formula (I) and their use as medicaments.

Abstract: An inhaler for inhaling powdered medicaments from capsules, having: a lower part which is cup-shaped, a plate latched to the lower part to close off the lower part, a capsule holder arranged on the underside of the plate, a mouthpiece that can be latched to the top of plate, and an actuating member for interacting with at least one pin for piercing a capsule in the capsule holder, where the actuating member includes a larger outer actuating member and a smaller inner actuating member, the outer actuating member forms a user-operated push-button, the inner actuating member contacts and holds the pin below a suspension element of the outer actuating member from the plate, and the point of application of force by the user onto push-button is lower than the inner actuating member.

Abstract: A process for producing a container comprising an outer container, an inner bag disposed therein and a pressure equalisation opening disposed in the outer container, and a container produced according to this process, is described, wherein a pre-moulding, comprising two coaxial tubes, is first produced by co-extrusion with the help of a blow mould and with an outwardly-projecting base seam being formed. The process forms a pressure equalisation opening in the outer container without endangering the integrity of the container, wherein a lower wastage rate and higher productivity are achieved. To do this, the base seam is partially cut off and a force which acts in the direction of the seam is introduced into the pre-moulding, which has a temperature of 40 degrees C. to 70 degrees C., which force breaks open and plastically deforms the base seam so that a pressure equalisation opening is formed in the base area.

Abstract: A grab for a surgical instrument has an elongated tube having a rigid outer part and a rigid inner part interconnected by a pivot pin extending along an axis transverse to the parts. A pair of jaws are pivotal on an outer end of the outer part between open and closed positions. An elongated actuating rod has a rigid outer part in the outer tube part and connected to the jaws, a rigid inner part in the inner tube part, and a flexible center part longitudinally interconnecting the rod inner and outer parts and passing through or around the pivot pin. The pivot pin is formed on the pivot axis with a throughgoing slot and the flexible part of the rod extends through the slot.

Abstract: The present invention relates to a method, a device, and a control program for the fluid-tight sealing of capsules containing medicaments, wherein the capsules consist of at least one capsule body and a capsule cap which are set one into the other telescopically and provided with a tight band in the abutment region on the exterior side of the capsule, wherein the capsule components are filled with gas which has a changed temperature and/or a changed pressure in relation to the environment, and wherein a reduction of the difference in pressure in the capsule occurs via gaps between capsule body and capsule cap after the capsule components have been placed one inside the other. The capsules produced via the method according to the invention are disposable capsules and preferably contain a single dose of an orally administered pharmaceutical formulation in the form of a powder or a liquid.

Abstract: A process for the production of a container (1) comprising an outer container (2), an inner bag (3) disposed therein and a pressure equalisation opening (10) disposed in the outer container (2), and also a container (1) produced according to this process, is described, wherein firstly a pre-moulding, comprising two coaxial tubes, is first produced by co-extrusion with the help of a blow mould and with an outwardly-projecting base seam (5) being formed. The process is to form a pressure equalisation opening (10) in the outer container (2) of the container (1) without endangering the integrity of the container (1), wherein a lower wastage rate and higher productivity are to be achieved. This is attained by a process wherein the base seam (5) is partially cut off and a force which acts in the direction of the seam is introduced into the pre-moulding, which still has a temperature of 40° C. to 70° C.

Abstract: A fan arrangement comprises a fan (10) having a fan housing (30) within which is arranged a blower wheel (18) which, in operation, moves air from an intake side of the fan (10) to a delivery side. Arranged radially outside the fan housing (30) is a surrounding mounting frame (34) that serves to support the fan housing (30). A membrane (32), made of an elastic material, elastically connects the fan housing (30) and mounting frame (34) to one another and is formed with through holes or apertures (33) that, in the event of a closure of the output or delivery side of the fan arrangement (40), enable a return flow, from the delivery side to the intake side of the fan arrangement (40), of air moved by the blower wheel (18).

Abstract: A fan arrangement comprises a fan (10) having a fan housing (30) within which is arranged a blower wheel (18) which, in operation, moves air from an intake side of the fan (10) to a delivery side. Arranged radially outside the fan housing (30) is a surrounding mounting frame (34) that serves to support the fan housing (30). A membrane (32), made of an elastic material, elastically connects the fan housing (30) and mounting frame (34) to one another and is formed with through holes or apertures (33) that, in the event of a closure of the output or delivery side of the fan arrangement (40), enable a return flow, from the delivery side to the intake side of the fan arrangement (40), of air moved by the blower wheel (18).

Abstract: A process for the production of a container (1) comprising an outer container (2), an inner bag (3) disposed therein and a pressure equalisation opening (10) disposed in the outer container (2), and also a container (1) produced according to this process, is described, wherein firstly a pre-moulding, comprising two coaxial tubes, is first produced by co-extrusion with the help of a blow mould and with an outwardly-projecting base seam (5) being formed. The process is to form a pressure equalisation opening (10) in the outer container (2) of the container (1) without endangering the integrity of the container (1), wherein a lower wastage rate and higher productivity are to be achieved. This is attained by a process wherein the base seam (5) is partially cut off and a force which acts in the direction of the seam is introduced into the pre-moulding, which still has a temperature of 40° C. to 70° C.

Abstract: A process for the production of a container (1) comprising an outer container (2), an inner bag (3) disposed therein and a pressure equalisation opening (10) disposed in the outer container (2), and also a container (1) produced according to this process, is described, wherein firstly a pre-moulding, comprising two coaxial tubes, is first produced by co-extrusion with the help of a blow mould and with an outwardly-projecting base seam (5) being formed. The process is to form a pressure equalisation opening (10) in the outer container (2) of the container (1) without endangering the integrity of the container (1), wherein a lower wastage rate and higher productivity are to be achieved. This is attained by a process wherein the base seam (5) is partially cut off and a force which acts in the direction of the seam is introduced into the pre-moulding, which still has a temperature of 40° C. to 70°C.

Abstract: A process for the production of a container (1) comprising an outer container (2), an inner bag (3) disposed therein and a pressure equalization opening (10) disposed in the outer container (2), and also a container (1) produced according to this process, is described, wherein firstly a pre-molding, comprising two coaxial tubes, is first produced by co-extrusion with the help of a blow mold and with an outwardly-projecting base seam (5) being formed. The process is to form a pressure equalization opening (10) in the outer container (2) of the container (1) without endangering the integrity of the container (1), wherein a lower wastage rate and higher productivity are to be achieved. This is attained by a process wherein the base seam (5) is partially cut off and a force which acts in the direction of the seam is introduced into the pre-molding, which still has a temperature of 40° C. to 70° C.

Abstract: An aircraft floodlight includes a lens placed in front of a housing thereof, a gas discharge lamp that is provided along with a reflector, and an electronic power supply unit. The housing has at least two reflectors that are aligned at different angles to one another and generate overlapping cones of light.

Abstract: A motor-vehicle lamp having a light-transmissive shield (3) which is attached to a grounding plate (4) by a holding device (8) and which defines an opening (6) suitable for water removal includes an electrically conductive pin (1) for protecting the motor-vehicle lamp from destruction due to a lightning strike, the pin having a first end extending into the opening (6) and a second end making electrically-conductive contact with an electrical ground (10, 10') of the motor vehicle.