Patents by Inventor Peter-Michael Kloetzel

Peter-Michael Kloetzel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • T CELL RECEPTORS FOR TUMOR SPECIFIC PROTEASOME SPLICE VARIANTS AND USES THEREOF
    Publication number: 20210061876
    Abstract: The present invention pertains to antigen recognizing constructs against tumor specific proteasome splicing variants. The invention in particular provides novel T cell receptor (TCR) based molecules which are selective and specific for tumor cells carrying antigenic epitopes generated by proteasome peptide splicing of tumor specific antigens. The TCRs of the invention, and antigen binding fragments derived therefrom, are of use for the diagnosis, treatment and prevention of proliferative diseases, preferably for the treatment of cancer. Further provided are nucleic acids encoding the antigen recognizing constructs of the invention, vectors comprising these nucleic acids, recombinant cells expressing the antigen recognizing constructs and pharmaceutical compositions comprising the compounds of the invention.
    Type: Application
    Filed: January 2, 2019
    Publication date: March 4, 2021
    Applicants: Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft, Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts, Imperial College Innovations Limited, Charité - Universitätsmedizin Berlin
    Inventors: Thomas BLANKENSTEIN, Gerald WILLIMSKY, Juliane LIEPE, Peter Michael KLOETZEL, Michele MISHTO, Christin BEIER
  • Mimetic peptides and the use thereof in the form of 20S, 26S and immunoproteasome inhibitors
    Patent number: 8835392
    Abstract: The present invention relates to peptide-mimetic compounds, the synthesis and use thereof fort he inhibition of proteasomes and the induction of apoptosis in tumor cells. The present invention furthermore relates to pharmaceutical compositions comprising the compounds and the use of the compounds for a treatment of diseases, in particular cancer and neurodegenerative diseases.
    Type: Grant
    Filed: March 3, 2006
    Date of Patent: September 16, 2014
    Assignees: Technische Universität, Charité—Universitätsmedizin Berlin
    Inventors: Boris Schmidt, Sumaira Umbreen, Hannes Braun, Peter-Michael Kloetzel, Ulrike Kuckelkorn
  • Mimetic Peptides and the Use Thereof in the Form of 20S, 26S and Immunoproteasome Inhitibors
    Publication number: 20090012007
    Abstract: The present invention relates to peptide-mimetic compounds, the synthesis and use thereof fort he inhibition of proteasomes and the induction of apoptosis in tumour cells. The present invention furthermore relates to pharmaceutical compositions comprising the compounds and the use of the compounds for a treatment of diseases, in particular cancer and neurodegenerative diseases.
    Type: Application
    Filed: March 3, 2006
    Publication date: January 8, 2009
    Inventors: Boris Schmidt, Sumaira Umbreen, Hannes Braun, Peter-Michael Kloetzel, Ulrike Kuckelkorn