Abstract: The present disclosure relates to compounds that are Syk inhibitors or pharmaceutically acceptable salts or co-crystals thereof, and pharmaceutical compositions thereof, and to their use in the treatment of various disease states, including cancer and inflammatory conditions.

Abstract: Systems and methods for generating encoded text representations of spoken utterances are disclosed. Audio data is received for a spoken utterance and analyzed to identify a nonverbal characteristic, such as a sentiment, a speaking rate, or a volume. An encoded text representation of the spoken utterance is generated, comprising a text transcription and a visual representation of the nonverbal characteristic. The visual representation comprises a geometric element, such as a graph or shape, or a variation in a text attribute, such as font, font size, or color. Analysis of the audio data and/or generation of the encoded text representation can be performed using machine learning.

Abstract: Searches based on an incoming ticket identify quality ticket enrichment data using a vector database. Language model prompts target particular kinds of quality ticket data. The incoming quality ticket, or a search result ticket, or both, are enriched using enrichment data, such as a user intent identification, a workaround suggestion, a resolution description, a target audience description, a relevance description, an impact description, a description of missing resolution facilitation information, an association between the incoming quality ticket and the search result ticket, a user sentiment identification, a tag suggestion, or a feedback utility estimate. The enrichment reduces engineering and support burdens, and facilitates faster more effective resolution of the problem or the request that is stated or implied in the incoming quality ticket. Duplicate tickets are merged or removed. Tickets are prioritized. Missing problem resolution information is identified and requested sooner.

Abstract: Sensor devices including dissolvable tissue-piercing tips are provided. The sensor devices can be used in conjunction with dissolvable needles configured for inserting the sensor devices into a host. Hardening agents for strengthening membranes on sensor devices are also provided. Methods of using and fabricating sensor devices are also provided.

Abstract: This disclosure describes techniques that enable a Meeting Expense and Verification (MEV) controller to infer the meeting expense of a proposed meeting. The MEV controller may analyze a meeting request to identify meeting attendees, and in doing so, determine the meeting expense. In response to the meeting expense being greater than a predetermined meeting expense threshold, the MEV controller may suspend the meeting request.

Abstract: Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system 800 comprising two working electrodes and at least one reference/counter electrode is provided. The sensor system 800 comprises first and second elongated bodies E1, E2, each formed of a conductive core or of a core with a conductive layer deposited thereon, insulating layer 810 that separates the conductive layer 820 from the elongated body, a membrane layer deposited on top of the elongated bodies E1, E2, and working electrodes 802?, 802? formed by removing portions of the conductive layer 820 and the insulating layer 810, thereby exposing electroactive surface of the elongated bodies E1, E2.

Abstract: A watercraft comprising a hull, a roof, a support including a first end coupled to the roof and a second end positioned within the hull, and an actuation assembly coupled to the support. The support is moveable between a first position and a second position in response to activation of the actuation assembly. The support extends into the hull a first distance in the first position and a second distance in the second position. The second distance is larger than the first distance.

Abstract: Pre-connected analyte sensors are provided. A pre-connected analyte sensor includes a sensor carrier attached to an analyte sensor. The sensor carrier includes a substrate configured for mechanical coupling of the sensor to testing, calibration, or wearable equipment. The sensor carrier also includes conductive contacts for electrically coupling sensor electrodes to the testing, calibration, or wearable equipment.

Abstract: Systems and methods for improving generated images based on image accuracy and aesthetics are disclosed herein. For example, an image tuning system can receive an image generation prompt describing a first image. The system can generate a second image. The system can compute an accuracy metric and an aesthetic metric. The system can determine whether the accuracy metric and aesthetic metric are less than respective thresholds. The system can generate a seed artifact. The system can generate a third image approximating the first image based on the seed artifact. The system can transmit the third image for display at a user interface.

Abstract: Methods and systems are provided for heat sanitizing a vehicle. In one example, a method may include, responsive to receiving a request for cleaning an interior of a vehicle, adjusting a position of a sun shade based on at least one of an ambient temperature outside of the vehicle and a sun load of the vehicle, and operating a heating, ventilation, and air-conditioning (HVAC) system to heat the interior above an upper threshold temperature for a first threshold duration. In this way, the HVAC system may be advantageously used to expose the vehicle interior to temperatures that kill or inactive microbes.

Abstract: Methods and systems are provided for heat sanitizing a vehicle. In one example, a method may include, responsive to receiving a request for sanitization of a vehicle interior, activating an ultraviolet germicidal irradiation (UVGI) system and operating a heating, ventilation, and air-conditioning (HVAC) system to heat the vehicle interior above an upper threshold temperature for a threshold duration. In this way, the HVAC system may be advantageously used to expose the vehicle interior to temperatures that kill or inactive microbes while the UVGI system may supplement the heat sanitizing.

Abstract: Methods and systems are provided for heat sanitizing a vehicle. In one example, a method may include, while receiving power from an external power source and responsive to receiving a request for cleaning an interior of a vehicle, operating an electric heater of a heating, ventilation, and air-conditioning (HVAC) system to heat the interior above an upper threshold temperature for a first threshold duration using the power received from the external power source. In this way, the HVAC system may be advantageously used to expose the vehicle interior to temperatures that kill or inactive microbes while vehicle battery power and fuel are conserved by using power supplied from the external power source.

Abstract: Methods and systems are provided for heat sanitizing a vehicle. In one example, a method may include, responsive to receiving a request for sanitization of a vehicle interior, operating a heating, ventilation, and air-conditioning (HVAC) system to heat the vehicle interior above an upper threshold temperature for a threshold duration. In this way, the HVAC system may be advantageously used to expose the vehicle interior to temperatures that kill or inactive microbes.

Abstract: Methods and systems are provided for heat sanitizing a vehicle. In one example, a method may include, responsive to receiving a request for sanitization of a vehicle interior, activating an ultraviolet germicidal irradiation (UVGI) system and operating a heating, ventilation, and air-conditioning (HVAC) system to heat the vehicle interior above an upper threshold temperature for a threshold duration. In this way, the HVAC system may be advantageously used to expose the vehicle interior to temperatures that kill or inactive microbes while the UVGI system may supplement the heat sanitizing.

Abstract: Methods and systems are provided for heat sanitizing a vehicle. In one example, a method may include, while receiving power from an external power source and responsive to receiving a request for cleaning an interior of a vehicle, operating an electric heater of a heating, ventilation, and air-conditioning (HVAC) system to heat the interior above an upper threshold temperature for a first threshold duration using the power received from the external power source. In this way, the HVAC system may be advantageously used to expose the vehicle interior to temperatures that kill or inactive microbes while vehicle battery power and fuel are conserved by using power supplied from the external power source.

Abstract: Methods and systems are provided for heat sanitizing a vehicle. In one example, a method may include, responsive to receiving a request for cleaning an interior of a vehicle, adjusting a position of a sun shade based on at least one of an ambient temperature outside of the vehicle and a sun load of the vehicle, and operating a heating, ventilation, and air-conditioning (HVAC) system to heat the interior above an upper threshold temperature for a first threshold duration. In this way, the HVAC system may be advantageously used to expose the vehicle interior to temperatures that kill or inactive microbes.

Abstract: Methods and systems are provided for heat sanitizing a vehicle. In one example, a method may include, responsive to receiving a request for sanitization of a vehicle interior, operating a heating, ventilation, and air-conditioning (HVAC) system to heat the vehicle interior above an upper threshold temperature for a threshold duration. In this way, the HVAC system may be advantageously used to expose the vehicle interior to temperatures that kill or inactive microbes.

Abstract: Methods and systems are provided for regenerating an aftertreatment device of a vehicle. In one example, a method may include adjusting conditions of the regeneration in response to a stickiness of the exhaust valve. Adjusting conditions may include adjusting an air/fuel ratio and/or a post-injection amount.

Abstract: Methods and systems are provided for regenerating an aftertreatment device of a vehicle. In one example, a method may include adjusting conditions of the regeneration in response to a stickiness of the exhaust valve. Adjusting conditions may include adjusting an air/fuel ratio and/or a post-injection amount.

Abstract: A system and method for optimizing traveled routes of a fleet. The method comprises reconstructing routes traveled by vehicles of the fleet based on historical GPS traces of the fleet; determining stops made by the vehicles along the traveled routes; and classifying the stops into work stops and non-work stops; and optimizing routes for the work stops.