Abstract: The present disclosure describes methods and systems for use in the production of adeno-associated virus (AAV) particles, including recombinant adeno-associated virus (rAAV) particles. In certain embodiments, the production process and system use Spodoptera frugiperda insect cells (such as Sf9 or Sf21) as viral production cells (VPCs).

Abstract: The present disclosure describes methods and systems for use in the production of adeno-associated virus (AAV) particles, including recombinant adeno-associated virus (rAAV) particles. The production process and system use Baculoviral Expression Vectors (BEVs) and/or Baculoviral Infected Insect Cells (BIICs) in the production of AAV particles (e.g., rAAVs) which allow for the controlled expression of AAV structural (e.g., capsid) proteins, such as VP1, VP2, and VPS and the controlled expression of AAV nonstructural (e.g., replication) proteins, such as Rep78 and Rep52.

Abstract: The present invention relates to modified proteins and peptides that have reduced ability to bind to pre-existing antibodies. Such modified protein/peptide molecules can comprise C-terminal additions, extensions or tags and/or certain amino acid substitutions. Such modified molecules (e.g. fusions and conjugates) comprise proteins, peptides, antigen binding molecules, antibodies or antibody fragments such as single variable domains e.g. human immunoglobulin (antibody) single variable domains, and also single variable domains derived from non-human sources such as a llama or camel, e.g. a VHH including a Nanobody™ (described in e.g. WO 94/04678 and WO 95/04079 inter alia). The invention further relates to uses, formulations, compositions comprising such modified C terminally extended and/or amino acid substituted molecules and also to methods of production and expression of these molecules.

Abstract: The present disclosure relates to modified proteins and peptides that have reduced ability to bind to pre-existing antibodies. Such modified protein/peptide molecules can comprise C-terminal additions, extensions or tags and/or certain amino acid substitutions. Such modified molecules (e.g., fusions and conjugates) comprise proteins, peptides, antigen binding molecules, antibodies or antibody fragments such as single variable domains. The disclosure further relates to uses and formulations of compositions comprising such modified C-terminally extended and/or amino acid substituted molecules and also to methods of production and expression of these.

Abstract: The present disclosure relates to TSLP binding proteins, such as anti-TSLP single variable domains, polynucleotides encoding such TSLP binding proteins, pharmaceutical compositions and kits comprising said TSLP binding proteins and methods of manufacture. The present invention also concerns the use of such TSLP binding proteins in the treatment of diseases associated TSLP signaling, such as asthma.

Abstract: A method for manufacturing an article configured to enhance the coalescence of a dispersed phase from a continuous phase in an emulsion is presented. The method includes forming a pattern of a plurality of regions on a surface of the article, wherein a portion of the plurality of regions is substantially wetting with respect to the dispersed phase, and a portion of the plurality of regions is substantially non-wetting with respect to the dispersed phase. The pattern further includes a plurality of inter-connected regions that are substantially non-wetting with respect to the dispersed phase.

Abstract: The present disclosure relates to modified proteins and peptides that have reduced ability to bind to pre-existing antibodies. Such modified protein/peptide molecules can comprise C-terminal additions, extensions or tags and/or certain amino acid substitutions. Such modified molecules (e.g., fusions and conjugates) comprise proteins, peptides, antigen binding molecules, antibodies or antibody fragments such as single variable domains. The disclosure further relates to uses and formulations of compositions comprising such modified C-terminally extended and/or amino acid substituted molecules and also to methods of production and expression of these.

Abstract: A heat sink for cooling at least one electronic device package is provided. The electronic device package has an upper contact surface and a lower contact surface. The heat sink comprises at least one thermally conductive material and defines multiple inlet manifolds configured to receive a coolant, multiple outlet manifolds configured to exhaust the coolant, and multiple millichannels configured to receive the coolant from the inlet manifolds and to deliver the coolant to the outlet manifolds. The manifolds and millichannels are disposed proximate to the respective one of the upper and lower contact surface of the electronic device package for cooling the respective surface with the coolant.

Abstract: A pharmaceutical care practitioner has a n ongoing relationship with a patient in a series of encounters. The practitioner generates an assessment, including demographics of the patient, resulting in a set of indications for pharmacotherapy. The practitioner evaluates medications for appropriateness, effectiveness, safety, and compliance, and recommends or selects medications (including dosage, duration, frequency, etc.) for each indication in a care plan. The practitioner evaluates outcomes from the medications. Items from the assessment, plan, or outcomes are coded as searchable terms in a patient database employed by the practitioner for generating the care plan. The patient database may be consolidated among many different practitioners for greater statistical power. Agreements between practitioners and third-party providers may permit practitioners to override or allow actions not normally permitted by patients' plans, such as drug substitution, dosage adjustment, or choice of source.

Abstract: A real-time, high uptime transaction processing system includes many user terminals communicating with service providers via a communications network. A defective logic board is replaced or a board providing system expansion is installed without powering down the system by providing external auxiliary voltages and a reset signal to the board to put it in a passive state while it is being plugged into or unplugged from its backplane connector. Also under computer control the system is made inactive for a short period of time.

Abstract: Data communication equipment, including relay modules and MODEMS, are mounted on etched back planes. Etched conductors transfer communication line signal pairs to the relay modules, from the relay modules to the MODEMS and from the MODEMS to an output connector. Ribbon cables plugged into the output connectors transfer the MODEM output signals to logic boards, which are plugged into an etched VME bus panel. CPU's plugged into the etched VME bush panel receive signals from and transfer signals to the etched VME bus.

Abstract: The present invention is directed to a lamp assembly for use in atomic absorption spectrometers in which an atomic element hollow cathode lamp assembly has a lamp formed by a hollow cathode electrode and an anode electrode within a sealed envelope. A base structure is attached to the envelope, and located within the base structure is a resistor network consisting of four resistors connected to a common lead and having four plug terminals protruding from the base structure. Two further plug terminals also protruding from the base structure are connected respectively to the cathode and anode electrodes to provide a connecting structure for connecting these electrodes to a lamp power supply. The five plug terminals protruding from the base structure and connected respectively to the resistors and the common lead provide a further connecting structure of the resistor network to a measurement circuit in an atomic absorption spectrophotometer.

Abstract: An improved source lamp assembly for use in atomic absorption spectrophotometers is described having encoded structures for identifying the atomic element of the source lamp assembly, as well as to represent lamp operating current. The encoding structures are formed by way of mechanical, optical, or magnetic means. In particular, a mechanical arrangement involves a plurality of projections and recesses, either formed relative to a base structure of the lamp assembly or relative to an attached card-like structure. A card reading device is used to read this card-like structure. These alternative arrangements can be also used relative to optical encoding or magnetic encoding.

Abstract: In atomic spectrophotometers comprising a source of radiation characteristic of an element to be detected in a sample, a monochromator for selecting a desired spectral line from radiation received from the source by the sample, and a detector for producing an output signal from the monochromator output radiation, the monochromator is accurately tuned to the desired line to obtain a maximum detector signal, and simultaneously, the gain of the detector is adjusted to keep the signal magnitude within the best working range of subsequent signal processing circuits. In accordance with the present invention, both adjustments are made simultaneously by comparing an amplified detector signal with a desired reference signal level corresponding to the best signal magnitude, and using the difference between them to adjust the gain of the amplified detector signal in a closed loop control system to continuously equalize the amplified detector signal with the reference level.