Abstract: A spike adapter and blunt cannula spike adapter assembly comprises a spike adapter having a hollow chamber extending axially therethrough from a first body end to a second body end. The hollow chamber is adapted to receive and accommodate attachment with a blunt cannula therein. A spike shaft projects axially outwardly away from the adapter body second end and has a sharpened tip at a distal end. A spike cover is disposed over the spike shaft to cover the sharpened tip. The spike shaft includes a hollow channel extending axially therethrough that is adapted to accommodate placement of a blunt cannula shaft concentrically therein to allow the blunt cannula to access medicine containers having unslit septums or stoppers. The spike adapter body includes axially extending grooves that accommodate blunt cannula tongues therein to form a tongue and groove attachment therebetween.