Patents by Inventor Peter N. Monk

Peter N. Monk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Discovery of the first selective C5A receptor 2 (C5L2/C5AR2) ligands
    Patent number: 10280197
    Abstract: A method of selectively modulating the activity of C5a receptor 2 (C5aR2). The method includes exposing the receptor to a compound that selectively modulates C5aR2 compared to C5a receptor 1 (C5aR1). In some cases, the compound is peptide P32 or P59. Methods of recruiting ?-arrestin 2 in a cell, modulating C5a-induced ERK1/2 activation in a macrophage, selectively inhibiting the release of IL-6 from a macrophage, are also provided.
    Type: Grant
    Filed: October 17, 2016
    Date of Patent: May 7, 2019
    Assignees: The Regents of the University of California, The Texas A & M University System, The University of Queensland, The University of Sheffield
    Inventors: Dimitrios Monikis, Christodoulos Floudas, Trent Woodruff, Matthew A. Cooper, Daniel E. Croker, Peter N. Monk
  • DISCOVERY OF THE FIRST SELECTIVE C5A2 RECEPTOR (C5L2/C5AR2) LIGANDS
    Publication number: 20170129921
    Abstract: A method of selectively modulating the activity of C5a receptor 2 (C5aR2). The method includes exposing the receptor to a compound that selectively modulates C5aR2 compared to C5a receptor 1 (C5aR1). In some cases, the compound is peptide P32 or P59. Methods of recruiting ?-arrestin 2 in a cell, modulating C5a-induced ERK1/2 activation in a macrophage, selectively inhibiting the release of IL-6 from a macrophage, are also provided.
    Type: Application
    Filed: October 17, 2016
    Publication date: May 11, 2017
    Inventors: Dimitrios Morikis, Christodoulos A. Floudas, Trent M. Woodruff, Matthew A. Cooper, Daniel E. Croker, Peter N. Monk